EDC Science Weekly, Feb. 26 – Mar. 3, 2020

A summary of articles on endocrine disrupting chemicals (EDCs) added to PubMed this week.

Contents: Interesting Research of the Week,Regulations/Policy, Methods/Screening, Reviews, Human Health Studies, Laboratory Studies, Exposure/Environment Studies.

Interesting Research of the Week

A comprehensive analysis of racial disparities in chemical biomarker concentrations in United States women, 1999-2014.

Regulations/Policy

Water Quality Impairments Due to Aquatic Life Pesticide Toxicity: Prevention and Mitigation in California, USA.

Hazardous air pollutant emissions implications under 2018 guidance on Clean Air Act requirements for major sources.

Selection of pesticides to reduce human and environmental health risks: a global guideline and minimum pesticides list.

Methods/Screening

Joint Virtual Special Issue on Computational Toxicology.[from the Journal of Chemical Information and Modeling (JCIM) and Chemical Research in Toxicology (CRT)]

A strategy for an initial assessment of the ecotoxicological effects of transformation products of pesticides in aquatic systems following a tiered approach.

Chained Risk Assessment for Life-Long Disease Burden of Early Exposures – Demonstration of Concept Using Prenatal Maternal Smoking.

Suspect and non-target screening of pesticides and pharmaceuticals transformation products in wastewater using QTOF-MS.

Reviews

Commentaries/Conference Summaries

CHDS: A National Treasure that Keeps on Giving.

Biomedical research meets toxicology: How in vitro chromosome instability method

Lessons Learned from the Australian Bushfires: Climate Change, Air Pollution, and Public Health.

Air pollution, climate changes and cardiovascular diseases: a nightmare threesome!

MCCP: are medium-chain chlorinated paraffins of concern for humans? [Letter]

BPA/Phenols

Bisphenol A and Phthalates in Diet: An Emerging Link with Pregnancy Complications.

Bisphenol S in Food Causes Hormonal and Obesogenic Effects Comparable to or Worse than Bisphenol A: A Literature Review.

Environmental exposure to nonylphenol and cancer progression Risk-A systematic review.

Estrogen and Bisphenol A in Hypertension.

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

Persistent environmental endocrine-disrupting chemicals in ovarian follicular fluid and in vitro fertilization treatment outcome in women.

Organochlorine pesticides: Agrochemicals with potent endocrine-disrupting properties in fish.

Graves’ disease: Epidemiology, genetic and environmental risk factors and viruses.

Perfluoroalkyl Substances

Per- and Polyfluoroalkyl Substances: An Emerging Contaminant of Concern.

Pesticides

Exposure to glyphosate and risk of non-Hodgkin lymphoma and multiple myeloma: an updated meta-analysis.

Effects of low-dose chlorpyrifos on neurobehavior and potential mechanisms: A review of studies in rodents, zebrafish, and Caenorhabditis elegans.

In vitro metabolism of pesticides and industrial chemicals in fish.

Microplastics

Toxicity of Microplastics and Nanoplastics in Mammalian Systems.

Air Pollution

Ambient air pollution and gestational diabetes mellitus: A review of evidence from biological mechanisms to population epidemiology.

A systematic review of the health effects associated with the inhalation of particle-filtered and whole diesel exhaust.

The contribution of particulate matter to respiratory allergy: A review of current evidence.

A Scoping Review of Nurses’ Contributions to Health-Related, Wildfire Research.

Why Do Intrauterine Exposure to Air Pollution and Cigarette Smoke Increase the Risk of Asthma?

Pharmaceuticals

Pharmaceutical Mixtures: Still A Concern for Human and Environmental Health.

Miscellaneous

Endocrine-Disrupting Chemicals in Human Fetal Growth.

Oestrogenic Endocrine Disruptors in the Placenta and the Fetus.

Hypothetical roadmap towards endometriosis: prenatal endocrine-disrupting chemical pollutant exposure, anogenital distance, gut-genital microbiota and subclinical infections.

Multiple risk factors: A challenge in the management of Autism.

Toxicities of Polycyclic Aromatic Hydrocarbons for Aquatic Animals.

Nepal: country report on children’s environmental health.

Human Health Studies

BPA/Phenols

Maternal and paternal preconception exposure to phenols and preterm birth.

Parabens/Triclosan/Antimicrobials

Mass Spectrometry-Based Metabolomics Reveals Paraben Exposure Related to Purine Metabolism and Other Pathways.

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

Intensive weight loss and cognition: The dynamics of persistent organic pollutants in adipose tissue can explain the unexpected results from the Action for Health in Diabetes (Look AHEAD) study.

Examining Reproductive Health Outcomes in Females Exposed to Polychlorinated Biphenyl and Polybrominated Biphenyl.

Perfluoroalkyl Substances

Variabilities in concentrations of selected perfluoroalkyl acids among normotensives and hypertensives across various stages of glomerular function.

Exposure to PFAS and small for gestational age new-borns: A birth records study in Veneto Region (Italy).

Flame Retardants

Prenatal Exposure to Organophosphate Flame Retardants and the Risk of Low Birth Weight: A Nested Case-Control Study in China.

Pesticides

Exposure to Environmental Toxicants and Early Language Development for Children Reared in Low-Income Households.

Chromosomal Instability in Farmers Exposed to Pesticides: High Prevalence of Clonal and Non-Clonal Chromosomal Alterations.

Indicators of Genotoxicity in Farmers and Laborers of Ecological and Conventional Banana Plantations in Ecuador.

Identification of markers of depression and neurotoxicity in pesticide exposed agriculture workers.

Potentially Toxic Elements

Chronic exposure to heavy metals from informal e-waste recycling plants and children’s attention, executive function and academic performance.

Attention deficit hyperactivity disorder and its association with heavy metals in children from northern Chile.

Exposure to heavy metals and its association with DNA oxidative damage in municipal waste incinerator workers in Shenzhen, China.

Evaluation of Pb concentrations in selected vegetables and portable drinking water, and intelligent quotients of school children in Ishiagu-a Pb mining community: health risk assessment using predictive modelling.

Air Pollution

Ambient air pollution and incidence of early-onset paediatric type 1 diabetes: A retrospective population-based cohort study.

Gaseous Pollutants and Particulate Matter (PM) in Ambient Air and the Number of New Cases of Type 1 Diabetes in Children and Adolescents in the Pomeranian Voivodeship, Poland.

Understanding the joint impacts of fine particulate matter concentration and composition on the incidence and mortality of cardiovascular disease: a component-adjusted approach.

Prenatal Ambient Particulate Matter Exposure and Longitudinal Weight Growth Trajectories in Early Childhood.

Exposure to air pollution during childhood and risk of developing schizophrenia: a national cohort study.

The Impact of Chronic Ambient Exposure to PM2.5 and Ozone on Asthma Prevalence and COPD Mortality Rates in the Southeastern United States.

Particulate matter pollution and hospital outpatient visits for endocrine, digestive, urological, and dermatological diseases in Nanjing, China.

Particulate Matter and Albuminuria, Glomerular Filtration Rate, and Incident CKD.

Exposure to fine particulate matter (PM2.5) and pediatric rheumatic diseases.

Maternal exposure to ambient air pollution during pregnancy and lipid profile in umbilical cord blood samples; a cross-sectional study.

Maternal exposure to ambient particulate matter and green spaces and fetal renal function.

Laboratory Studies

BPA/Phenols

Evaluation of the influence of halogenation on the binding of bisphenol A to the estrogen-related receptor γ.

Neonatal exposure to bisphenol A advances pubertal development in female rats.

Phthalates

Oxidative damage in the liver and kidney induced by dermal exposure to diisononyl phthalate in Balb/c mice.

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

Prebiotic inulin consumption reduces dioxin-like PCB 126-mediated hepatotoxicity and gut dysbiosis in hyperlipidemic Ldlr deficient mice.

Skeletal Toxicity of Coplanar Polychlorinated Biphenyl Congener 126 in the Rat is Aryl Hydrocarbon Receptor-Dependent.

Dioxin Male Rat Reproductive Toxicity Mode of Action and Relative Potency of 2,3,7,8-Tetrachlorodibenzo-p-dioxin and 2,3,7,8-Tetrachlorodibenzofuran Characterized by Fetal Pituitary and Testis Transcriptome Profiling.

Perfluoroalkyl Substances

Comparative Analysis of PFOS and PFOA Toxicity on Sertoli Cells.

Gestational Perfluorooctanoic Acid Exposure Inhibits Placental Development by Dysregulation of Labyrinth Vessels and uNK Cells and Apoptosis in Mice.

Albumin is the major carrier protein for PFOS, PFOA, PFHxS, PFNA and PFDA in human plasma.

Perfluorinated alkylsubstances of significant environmental concern can strongly inhibit human carbonic anhydrase isozymes.

Chronic Reproductive Toxicity of PFOS and a Simple Mixture of PFOS and PFHxS to Northern Bobwhite Quail (Colinus virginianus).

Effects of gestational Perfluorooctane Sulfonate exposure on the developments of fetal and adult Leydig cells in F1 males.

Flame Retardants

Transcriptomic profiling of PBDE-exposed HepaRG cells unveils critical lncRNA- PCG pairs involved in intermediary metabolism.

Organotins

Toll-like receptors (TLRs) respond to tributyltin chloride (TBT-Cl) exposure in the river pufferfish (Takifugu obscurus): Evidences for its toxic injury function.

Pesticides

Neuroprotective effects of mitochondria-targeted curcumin against rotenone-induced oxidative damage in cerebellum of mice.

Identification of common key regulators in rat hepatocyte cell lines under exposure of different pesticide.

Bioallethrin-induced generation of reactive species and oxidative damage in isolated human erythrocytes.

Tolerance of Novel Toxins through Generalized Mechanisms: Simulating Gradual Host Shifts of Butterflies.

Thiamethoxam impairs honey bee visual learning, alters decision times, and increases abnormal behaviors.

Chlorpyrifos induces apoptosis and autophagy in common carp lymphocytes by influencing the TCR γ-dependent PI3K/AKT/JNK pathway.

Genotoxicity and oxidative stress in Caiman latirostris hatchlings exposed to pesticide formulations and their mixtures during incubation period.

In vitro effects of glyphosate-based herbicides and related adjuvants on primary culture of hemocytes from Haliotis tuberculata.

The effect of neonicotinoid insecticide thiacloprid on the structure and stability of DNA.

Potentially Toxic Elements

Arsenic-induced Autophagic Alterations and Mitochondrial Impairments in HPG-S Axis of Mature Male Mice Offspring (F1-generation): A persistent toxicity study.

Arsenic concentrations, diversity and co-occurrence patterns of bacterial and fungal communities in the feces of mice under sub-chronic arsenic exposure through food.

Low Doses of Methylmercury Induce the Proliferation of Thyroid Cells In Vitro Through Modulation of ERK Pathway.

Effects of waterborne exposure to cadmium on biochemical responses in the freshwater gastropod, Bellamya aeruginosa.

Microplastics

Desorption of pharmaceuticals from pristine and aged polystyrene microplastics under simulated gastrointestinal conditions.

Nanoplastics Cause Neurobehavioral Impairments, Reproductive and Oxidative Damages, and Biomarker Responses in Zebrafish: Throwing up Alarms of Wide Spread Health Risk of Exposure.

Air Pollution

Particulate matter (PM10) induces cardiovascular developmental toxicity in zebrafish embryos and larvae via the ERS, Nrf2 and Wnt pathways.

Pharmaceuticals

Chronic exposure to environmentally relevant levels of simvastatin disrupts zebrafish brain gene signaling involved in energy metabolism.

Using zebrafish to assess the effect of chronic, early developmental exposure to environmentally relevant concentrations of 5-fluorouracil and leucovorin.

Mixtures

Assessment of developmental neurotoxicity induced by chemical mixtures using an adverse outcome pathway concept.

Joint Toxicity of a Multi-Heavy Metal Mixture and Chemoprevention in Sprague Dawley Rats.

Assessment of antioxidant system, cholinesterase activity and histopathology in Lithobates catesbeianus tadpoles exposed to water from an urban stream.

Effects of microplastics and mercury on manila clam Ruditapes philippinarum: Feeding rate, immunomodulation, histopathology and oxidative stress.

Honeybee gut microbiota dysbiosis in pesticide/parasite co-exposures is mainly induced by Nosema ceranae.

Alterations in viability and CYP1A1 expression in SH SY5Y cell line by pollutants present in Madín Dam, Mexico.

Exposure/Environment Studies

BPA/Phenols

Spatial and Temporal Distribution of BPA in the Canadian Freshwater Environment.

Phthalates

Lowering urinary phthalate metabolite concentrations among children by reducing contaminated dust in housing units: A randomized controlled trial and observational study.

Trends for plasticizers in German freshwater environments – Evidence for the substitution of DEHP with emerging phthalate and non-phthalate alternatives.

Phthalate exposure in Chinese homes and its association with household consumer products.

Analysis of phthalate plasticizer migration from PVDC packaging materials to food simulants using molecular dynamics simulations and artificial neural network.

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

Polychlorinated Biphenyls (PCBs) and Sex Hormone Concentrations in Ringed and Grey Seals: A Possible Link to Endocrine Disruption?

Perfluoroalkyl Substances

Exposure to Perfluoroalkyl Substances in a Cohort of Women Firefighters and Office Workers in San Francisco.

Environmental contamination and human exposure to PFASs near a fluorochemical production plant: Review of historic and current PFOA and GenX contamination in the Netherlands.

Origin and organ-specific bioaccumulation pattern of perfluorinated alkyl substances in crabs.

Flame Retardants

Functional Group-Dependent Screening of Organophosphate Esters (OPEs), and Discovery of an Abundant OPE Bis-(2-Ethylhexyl)-Phenyl Phosphate (BEHPP) in Indoor Dust.

Human exposure to legacy and emerging flame retardants in indoor dust: A multiple-exposure assessment of PBDEs.

Leaching of brominated flame retardants (BFRs) from BFRs-incorporated plastics in digestive fluids and the influence of bird diets.

Pesticides

Systematic review of methods used to assess exposure to pesticides in occupational epidemiology studies, 1993-2017.

Concentrations and temporal trends in pesticide biomarkers in urine of Swedish adolescents, 2000-2017.

Characterizing the Neurodevelopmental Pesticide Exposome in a Children’s Agricultural Cohort.

Pesticide pollution in freshwater paves the way for schistosomiasis transmission.

Potentially Toxic Elements

Simultaneous analysis of typical halogenated endocrine disrupting chemicals and metal(loid)s in human hair. [also POPs]

Characterization of urinary concentrations of heavy metals among socioeconomically disadvantaged black pregnant women.

Adipose tissue concentrations of arsenic, nickel, lead, tin, and titanium in adults from GraMo cohort in Southern Spain: An exploratory study.

External interference from ambient air pollution on using hair metal(loid)s for biomarker-based exposure assessment.

Public health risk of toxic metal(loid) pollution to the population living near an abandoned small-scale polymetallic mine.

Input of terrestrial organic matter linked to deglaciation increased mercury transport to the Svalbard fjords.

Effect of Accumulation of Heavy Metals in the Red Fox Intestine on the Prevalence of Its Intestinal Parasites.

Combination of compositional data analysis and machine learning approaches to identify sources and geochemical associations of potentially toxic elements in soil and assess the associated human health risk in a mining city.

Levels, sources, isotope signatures, and health risks of mercury in street dust across China.

Microplastics

A Review of Microplastics in Table salt, Drinking Water, and Air: Direct Human Exposure.

Microfibre release to water, via laundering, and to air, via everyday use: a comparison between polyester clothing with differing textile parameters.

Metro station free drinking water fountain- A potential “microplastics hotspot” for human consumption.

Organic pollutants in sedimentary microplastics from eastern Guangdong: Spatial distribution and source identification.

Pharmaceuticals

Poultry Farms as a Potential Source of Environmental Pollution by Pharmaceuticals.

Mixtures

Immune defense parameters of wild fish as sensitive biomarkers for ecological risk assessment in shallow sea ecosystems: A case study with wild mullet (Liza haematocheila) in Liaodong Bay.

Miscellaneous

Chlorinated Paraffins in Human Milk from Urban Sites in China, Sweden, and Norway.

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This list is not meant to be exhaustive, and generally does not include studies on detection, remediation, or treatment of EDCs. Note that journal publication dates may be different than dates added to PubMed. To see the searchable archives, please email me at Sarah@healthandenvironment.org and ask to join the group EDC_research@googlegroups.com. Archives are at https://groups.google.com/d/forum/edc_research. Compiled by Sarah Howard, Diabetes and Environment Program and HEEDS at Commonweal.