EDC Science Weekly, Jan. 29 – Feb. 4, 2020 – HEEDS

EDC Science Weekly, Jan. 29 – Feb. 4, 2020

Post author:HEEDS
Post published:February 4, 2020
Post category:EDC Science Weekly

A summary of articles on endocrine disrupting chemicals (EDCs) added to PubMed this week.

Contents: Methods/Screening, Reviews, Human Health Studies, Laboratory Studies, Exposure/Environment Studies.

Methods/Screening

Environmental risk assessment of accidental marine spills: A new approach combining an online dynamic Hazardous and Noxious substances database with numerical dispersion, risk and population modelling.

Transthyretin-Binding Activity of Complex Mixtures Representing the Composition of Thyroid-Hormone Disrupting Contaminants in House Dust and Human Serum.

The potential endocrine disruption of pesticide transformation products (TPs): The blind spot of pesticide risk assessment.

Reviews

Commentaries/Conference Summaries

Leaving Environmental Health Perspectives on a High Note. [Retirement of EHP editor]

Soil contamination and human health: Part 1-preface. [special issue in Environmental Geochemistry and Health]

Pesticides

Current Status of Ecotoxicological Studies of Bats in Brazil.

Chronic kidney disease of non-traditional origin in Mesoamerica: a disease primarily driven by occupational heat stress.

Potentially Toxic Elements

Molecular Mechanisms of Arsenic-induced Disruption of DNA Repair.

Protective Effects of Dietary Antioxidants against Vanadium-Induced Toxicity: A Review.

Air Pollution

Air pollution and its effects on the immune system.

Antioxidant genes and susceptibility to air pollution for respiratory and cardiovascular health.

microRNAs expression in relation to particulate matter exposure: A systematic review.

Traffic-related environmental factors and childhood obesity: A systematic review and meta-analysis.

Miscellaneous

Type 1 diabetes-early life origins and changing epidemiology.

Environmental Exposures and Autoimmune Diseases: Contribution of Gut Microbiome. [various chemicals]

The gut microbiome: an orchestrator of xenobiotic metabolism.

Soil toxicants that potentially affect children’s health. [metals, POPs, PFAS, etc.]

Trichloroethylene, a ubiquitous environmental contaminant in the risk for Parkinson’s disease.

Food Color and Autism: A Meta-Analysis.

Synthetic Chemical Trade as a Potential Driver of Global Health Disparities and Data Gaps on Synthetic Chemicals in Vulnerable Populations.

Human Health Studies

BPA/Phenols

Prenatal exposure to bisphenol A and its alternatives and child neurodevelopment at 2 years.

Phthalates

Phthalates and sex steroid hormones among men from NHANES, 2013-2016.

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

Polychlorinated dibenzo-dioxins and polychlorinated dibenzo-furans exposure and altered lung function: The mediating role of oxidative stress.

Reduction of mitochondrial DNA copy number in peripheral blood is related to polycyclic aromatic hydrocarbons exposure in coke oven workers: Bayesian kernel machine regression.

Serum concentrations of persistent organic pollutants and the metabolic syndrome in Akwesasne Mohawks, a Native American community.

Pesticides

Biological variation in kidney injury and kidney function biomarkers among farmers in Lamphun province, Thailand.

2,4-D exposure and urinary markers of oxidative DNA damage and lipid peroxidation: a longitudinal study.

Magnitude of Behavioral Deficits Varies with Job-Related Chlorpyrifos Exposure Levels among Egyptian Pesticide Workers.

Potentially Toxic Elements

Association of urinary cadmium, circulating fatty acids, and risk of gestational diabetes mellitus: A nested case-control study in China.

Methylmercury and long chain polyunsaturated fatty acids are associated with immune dysregulation in young adults from the Seychelles child development study.

Assessing potential mechanisms of arsenic-induced skin lesions and cancers: Human and in vitro evidence.

Multiple metal exposure and platelet counts during pregnancy: A repeated measure study.

Blood Harmane (1-Methyl-9H-Pyrido[3,4-b]indole) and Mercury in Essential Tremor: A Population-Based, Environmental Epidemiology Study in the Faroe Islands.

Selenium-associated DNA methylation modifications in placenta and neurobehavioral development of newborns: An epigenome-wide study of two U.S. birth cohorts.

A nomogram for predicting the renal dysfunction in a Chinese population with reduction in cadmium exposure based on an 8 years follow up study.

Elemental bioimaging shows mercury and other toxic metals in normal breast tissue and in breast cancers.

Air Pollution

Alzheimer disease starts in childhood in polluted Metropolitan Mexico City. A major health crisis in progress.

All-source and source-specific air pollution and 10-year diabetes Incidence: Total effect and mediation analyses in the Heinz Nixdorf recall study.

Investigating associations between anti-nuclear antibody positivity and combined long-term exposures to NO2, O3, and PM2.5 using a Bayesian kernel machine regression approach.

The impact of ambient ozone pollution on pneumonia: A nationwide time-series analysis.

Periconceptional exposure to air pollution and congenital hypospadias among full-term infants.

Exposure to ambient air pollution and early childhood behavior: A longitudinal cohort study.

Associations of ambient air pollutant exposure with seminal plasma MDA, sperm mtDNA copy number, and mtDNA integrity.

Short-term exposure to ambient fine particulate matter and out-of-hospital cardiac arrest: a nationwide case-crossover study in Japan.

Industrial pollution and human health: evidence from middle-income countries.

Ambient fine particulate matter and hospital admissions for ischemic and hemorrhagic strokes and transient ischemic attack in 248 Chinese cities.

Estimating health burden and economic loss attributable to short-term exposure to multiple air pollutants in China.

Miscellaneous

Association between proximity to industrial chemical installations and cancer mortality in Spain.

Laboratory Studies

BPA/Phenols

The mixture effects of bisphenol derivatives on estrogen receptor and androgen receptor.

Evaluation of the effects of low concentrations of bisphenol AF on gonadal development using the Xenopus laevis model: A finding of testicular differentiation inhibition coupled with feminization.

Mechanisms underlying disruption of oocyte spindle stability by bisphenol compounds.

Investigation of antioxidant responses in Gammarus pulex exposed to Bisphenol A.

Potentiation of the glycine response by bisphenol A, an endocrine disrupter, on the substantia gelatinosa neurons of the trigeminal subnucleus caudalis in mice.

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

Long-term metabolic consequences of acute dioxin exposure differ between male and female mice.

Targeted toxicometabolomics of endosulfan sulfate in adult zebrafish (Danio rerio) using GC-MS/MS in multiple reaction monitoring mode.

Perfluoroalkyl Substances

Perfluoroalkyl substances increase susceptibility of northern leopard frog tadpoles to trematode infection.

An acute exposure to perfluorooctanoic acid causes non-reversible plasma membrane injury in HeLa cells.

Fetal bovine serum attenuating perfluorooctanoic acid-inducing toxicity to multiple human cell lines via albumin binding.

Flame Retardants

Multidisciplinary approach to determine the effect of polybrominated diphenyl ethers on gut microbiota.

Tris(4-hydroxyphenyl)ethane (THPE), a trisphenol compound, is antiestrogenic and can retard uterine development in CD-1 mice.

Structural binding interactions of tetrabromobisphenol A with sex steroid nuclear receptors and sex hormone-binding globulin.

6-OH-BDE-47 exposure-induced Parkinson’s disease pathology in Sprague Dawley rat.

Pesticides

Organophosphate agent induces ADHD-like behaviors via inhibition of brain endocannabinoid-hydrolyzing enzyme(s) in adolescent male rats.

The pyrethroid esfenvalerate induces hypoactivity and decreases dopamine transporter expression in embryonic/larval zebrafish (Danio rerio).

Understanding the influence of glyphosate on the structure and function of freshwater microbial community in a microcosm.

Toxicogenomics provides insights to toxicity pathways of neonicotinoids to aquatic insect, Chironomus dilutus.

Tebuconazole induced cardiotoxicity in male adult rat.

Single or combined exposure to chlorpyrifos and cypermethrin provoke oxidative stress and downregulation in monoamine oxidase and acetylcholinesterase gene expression of the rat’s brain.

Thiophanate-methyl induces severe hepatotoxicity in zebrafish.

Prenatal exposure to glufosinate ammonium disturbs gut microbiome and induces behavioral abnormalities in mice.

Potentially Toxic Elements

Arsenic hampered embryonic development: An in vivo study using local Bangladeshi Danio rerio model.

Arsenic transformation mediated by gut microbiota affects the fecundity of Caenorhabditis elegans.

Comparative cytotoxicity of inorganic arsenite and methylarsenite in human brain cells.

Effects of Cadmium and/or Lead on Autophagy and Liver Injury in Rats.

Copper and Lead Exposures Disturb Reproductive Features of Primary Endometrial Stromal and Epithelial Cells.

Microplastics

High density polyethylene (HDPE) microplastics impair development and swimming activity of Pacific oyster D-larvae, Crassostrea gigas, depending on particle size.

Microplastic ingestion by quagga mussels, Dreissena bugensis, and its effects on physiological processes.

Air Pollution

Activation of NLRP3 in microglia exacerbates diesel exhaust particles-induced impairment in learning and memory in mice.

Effects of PM2.5 and gases exposure during prenatal and early-life on autism-like phenotypes in male rat offspring.

Inhalation of printer-emitted particles impairs cardiac conduction, hemodynamics, and autonomic regulation and induces arrhythmia and electrical remodeling in rats.

Investigation of the chemical components of ambient fine particulate matter (PM2.5) associated with in vitro cellular responses to oxidative stress and inflammation.

Toxicity of urban air pollution particulate matter in developing and adult mouse brain: Comparison of total and filter-eluted nanoparticles.

Pharmaceuticals

Endocrine disruptive action of diclofenac and caffeine on Astyanax altiparanae males (Teleostei: Characiformes: Characidae).

Psychoactive compounds at environmental concentration alter burrowing behavior in the freshwater crayfish.

Mixtures

Anatomical and Behavioral Assessment of Larval Zebrafish (Danio rerio) Reared in Anacostia River Water Samples.

Polyethylene microplastics increase the toxicity of chlorpyrifos to the marine copepod Acartia tonsa.

Food-borne exposure of juvenile rainbow trout (Oncorhynchus mykiss) to benzotriazole UV stabilizers alone and in mixture induces specific transcriptional changes.

Miscellaneous

Developmental toxicity of trichloroethylene in zebrafish (Danio rerio).

Exposure/Environment Studies

Phthalates

Investigation of phthalate metabolites in urine and daily phthalate intakes among three age groups in Beijing, China.

Exposure of patients to di(2-ethylhexy)phthalate (DEHP) and its metabolite MEHP during extracorporeal membrane oxygenation (ECMO) therapy.

Concentrations of phthalate metabolites in Australian urine samples and their contribution to the per capita loads in wastewater.

Distribution and risk assessment of phthalates in water and sediment of the Pearl River Delta.

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

Organochlorine Pesticide Residues Among Colonial Nesting Birds in Tamil Nadu, India: A Maiden Assessment from Their Breeding Grounds.

The presence, emission and partitioning behavior of polychlorinated biphenyls in waste, leachate and aerosols from Norwegian waste-handling facilities.

Interspecies comparison of the residue levels and profiles of persistent organic pollutants in terrestrial top predators.

Perfluoroalkyl Substances

Contamination profiles and health risks of PFASs in groundwater of the Maozhou River basin.

Potential sources and sediment-pore water partitioning behaviors of emerging per/polyfluoroalkyl substances in the South Yellow Sea.

Flame Retardants

Serum elimination half-lives adjusted for ongoing exposure of tri-to hexabrominated diphenyl ethers: Determined in persons moving from North America to Australia.

Trends of production, consumption and environmental emissions of Decabromodiphenyl ether in mainland China.

Airborne brominated, chlorinated and organophosphate ester flame retardants inside the buildings of the Indian state of Bihar: Exploration of source and human exposure.

Longer commutes are associated with increased human exposure to tris(1,3-dichloro-2-propyl) phosphate.

Pesticides

Assessing dietary exposure risk to neonicotinoid residues among preschool children in regions of Taiwan.

Pesticides and conservation of large ungulates: Health risk to European bison from plant protection products as a result of crop depredation.

Potentially Toxic Elements

Predictors of urinary and blood Metal(loid) concentrations among pregnant women in Northern Puerto Rico.

Maternal-child exposure to metals during pregnancy in Rio de Janeiro city, Brazil: The Rio Birth Cohort Study of Environmental Exposure and Childhood Development (PIPA project).

Trace Elements in Blood of the Population Living near a Hazardous Waste Incinerator in Catalonia, Spain.

Oxidative stress risk assessment through heavy metal and arsenic exposure in terrestrial and aquatic bird species of Pakistan.

Female oxidative status in relation to calcium availability, metal pollution and offspring development in a wild passerine.

Heavy metal contamination in surface sediments: A comprehensive, large-scale evaluation for the Bohai Sea, China.

Ecological risk assessment of heavy metals in sediments and water from the coastal areas of the Bohai Sea and the Yellow Sea.

Elevated mercury concentrations in biota despite reduced sediment concentrations in a contaminated coastal area, Harboøre Tange, Denmark.

Pollution, sources and environmental risk assessment of heavy metals in the surface AMD water, sediments and surface soils around unexploited Rona Cu deposit, Tibet, China.

Metal contamination of river otters in North Carolina.

Mercury in fish marketed in the Amazon Triple Frontier and Health Risk Assessment.

Sewage Effluent Causes Metal Pollution of a Sub-tropical River System in Zimbabwe.

Food toxicity assessment of selected canned foods in Nigeria.

Ecological risk assessment of heavy metal concentrations in sediment and fish of a shallow lake: a case study of Baiyangdian Lake, North China.

Monitoring and assessment of cadmium, lead, zinc and copper concentrations in arable roadside soils in terms of different traffic conditions.

Health risk assessment of metal(loid)s in soil and particulate matter from industrialized regions: A multidisciplinary approach.

Microplastics

Underestimated Microplastic Pollution Derived from Fishery Activities and “Hidden” in Deep Sediment.

Microplastics and their possible sources: The example of Ofanto river in southeast Italy.

Microplastic pollution of the Tamsui River and its tributaries in northern Taiwan: Spatial heterogeneity and correlation with precipitation.

Floating macro- and microplastics around the Southern Ocean: Results from the Antarctic Circumnavigation Expedition.

Distribution, abundance, and diversity of microplastics in the upper St. Lawrence River.

Occurrence and Spatial Distribution of Microplastics in the surface Waters of Lake Naivasha, Kenya.

Branded milks – Are they immune from microplastics contamination?

Mixtures

Occupational Co-exposures to Multiple Chemical Agents from Workplace Measurements by the US Occupational Safety and Health Administration.

Miscellaneous

Eliminating Take-Home Exposures: Recognizing the Role of Occupational Health and Safety in Broader Community Health.

Private Wells and Rural Health: Groundwater Contaminants of Emerging Concern.

Dredging Contaminated Sediments: Is it Worth the Risks?

The emerging role of metallic nanoparticles in food.

——-

This list is not meant to be exhaustive, and generally does not include studies on detection, remediation, or treatment of EDCs. Note that journal publication dates may be different than dates added to PubMed. To see the searchable archives, please email me at Sarah@healthandenvironment.org and ask to join the group EDC_research@googlegroups.com. Archives are at https://groups.google.com/d/forum/edc_research. Compiled by Sarah Howard, Diabetes and Environment Program and HEEDS at Commonweal.

EHN EHN

Endocrine-disrupting chemicals: hazards and opportunities (ECHO) course
by Sarah Howard on October 31, 2024 at 2:50 pm
This course focuses on the chemical, biological, and societal challenges of endocrine-disrupting chemicals (EDCs) and new opportunities for moving forward. ECHO is a two-week intensive bootcamp-style career development course for graduate students, postdoctoral fellows, and professionals in the field. It is held at Woods Hole, Massachusetts.
Lou Guillette Jr. Memorial Symposium
by Sarah Howard on October 22, 2024 at 1:30 pm
On March 14-15, 2025, HEEDS is hosting the Lou Guillette Jr. Memorial Symposium on endocrine disrupting science at the University of Florida. It will celebrate the life and legacy of Dr. Guillette, gather together his trainees and colleagues, and focus on the research topics that Lou made famous. Information here.
Webinar: The overturning of Chevron deference: impacts on environmental health decision making
by Sarah Howard on October 17, 2024 at 4:21 pm
In this Nov. 13 webinar, legal experts will discuss the implications of the overturning of Chevron deference and its profound impact on science, public health and decision-making. Sponsored by CHE and UCSF's EaRTH Center.

EHN EHN

Ultra-processed foods and plastic packaging make for the ultimate toxic pair, scientists say
by Katherine McMahon,Sarah Howard on October 25, 2024 at 10:37 am
A recent paper published in Globalization and Health explores the relationship between ultra-processed foods (UPFs), plastic packaging, and their combined threat to public health. “Consumers do not have the power to solve a problem of this scale, and thus it is the responsibility of policymakers to ensure that transitions away from unhealthy, unsustainable foods are accompanied by structural measures that support demand and access to healthy foods.”
Microplastic exposure linked to reduced sperm quality in humans
by Katherine McMahon,Sarah Howard on October 23, 2024 at 4:29 pm
Exposure to microplastics is associated with a decrease in sperm concentration, motility, and shape, according to a new study published in The Lancet. “The identification of non-stick pan coating material PTFE as a particularly hazardous microplastic for male fertility underscores the importance of targeted interventions to reduce exposure to this and similar substances.”
Exposure to PFAS in ski wax may be linked to high cholesterol
by Katherine McMahon,Sarah Howard on October 16, 2024 at 7:42 pm
According to a new study published in Environmental Research, skiers and snowboarders may face health risks from their exposure to PFAS via ski wax, which can contain up to 100% PFAS by mass. “Interventions to remove PFAS from fluorinated wax could decrease direct exposure to skiers and reduce PFAS release into the environment.”

EHN EHN

Stricter toxic chemical rules reduce Californians’ exposures
by Kristina Marusic on October 31, 2024 at 11:25 am
Californians have lower levels of toxic chemicals linked to cancer, birth defects and reproductive harm in their bodies than people in the rest of the country, according to a new study. The study, published in Environmental Health Perspectives and conducted by researchers at Silent Spring Institute, a nonprofit scientific research organization, and the University of California at Berkeley (UC Berkeley), looked at nationwide data on the levels of 37 toxic chemicals in people’s blood before and after California introduced its stringent regulations. It found that for 18 of these chemicals, Californians have lower levels in their bodies than the rest of the country.
EPA dismissed data on the neurotoxicity of common insecticides
by Katherine McMahon,Sarah Howard on October 30, 2024 at 5:56 pm
A recent paper in Frontiers in Toxicology examined research submitted by industry to the U.S. Environmental Protection Agency (EPA) on the neurotoxicity of neonicotinoids - the most widely used class of insecticides in the U.S. and worldwide - and found that the data was evaluated improperly by the agency. Why this matters: Neonicotinoids are widely used not only for commercial agriculture but also for more personal uses like home gardens and in some flea and tick treatments for pets. Humans are regularly exposed to neonicotinoids – which are structurally similar to nicotine – through the environment, food and water. Neonicotinoids’ popularity partly comes from the belief that their harmful effects are mostly limited to insects, but studies like this one demonstrate that mammals may also be harmed by the chemicals, and highlight the urgent need for stronger regulations around their use.
Pesticide regulations ignore critical threats to insect health and ecosystems
by EHN Curators on October 30, 2024 at 10:26 am
In a study revealing regulatory gaps, researchers found that pesticides impact insect behavior and survival at non-lethal doses, especially in warmer temperatures, calling into question the effectiveness of current pesticide safety protocols. Dave Goulson writes for The Conversation.