EDC Science Weekly, Jan. 3 – 7, 2020 – HEEDS

EDC Science Weekly, Jan. 3 – 7, 2020

Post author:HEEDS
Post published:January 7, 2020
Post category:EDC Science Weekly

A summary of articles on endocrine disrupting chemicals (EDCs) added to PubMed this week.

Contents: Regulations/Policy, Methods/Screening, Reviews, Human Health Studies, Laboratory Studies, Exposure/Environment Studies.

Regulations/Policy

Emerging investigator series: use of behavioural endpoints in the regulation of chemicals.

Mercury Benefits of Climate Policy in China: Addressing the Paris Agreement and the Minamata Convention Simultaneously.

Deregulation and the Assault on Science and the Environment.

Methods/Screening

Bioactivity screening of environmental chemicals using imaging-based high-throughput phenotypic profiling.

Suspect screening of 200 hazardous substances in plastic toys using ultra-high-performance liquid chromatography-hybrid quadrupole time-of-flight mass spectrometry.

Reviews

Parabens/Triclosan/Antimicrobials

Review of the safety of application of cosmetic products containing parabens.

Fate, risk and removal of triclocarban: A critical review.

Perfluoroalkyl Substances

Treatment train approaches for the remediation of per- and polyfluoroalkyl substances (PFAS): A critical review.

Pesticides

Organophosphate exposure and the chronic effects on farmers: a narrative review.

Potentially Toxic Elements

A State-of-the-Science Review of Arsenic’s Effects on Glucose Homeostasis in Experimental Models.

Ecotoxicology of Heavy Metal(loid)-Enriched Particulate Matter: Foliar Accumulation by Plants and Health Impacts.

A critical review about neurotoxic effects in marine mammals of mercury and other trace elements.

Air Pollution

Association between air pollution and type 2 diabetes: an updated review of the literature.

Effect of long-term particulate matter exposure on Parkinson’s risk.

Impact of air pollution on intestinal redox lipidome and microbiome.

Miscellaneous

A review of the reproductive toxicity of T-2 toxin.

Human Health Studies

Perfluoroalkyl Substances

Perfluorooctanoic acid alters progesterone activity in human endometrial cells and induces reproductive alterations in young women.

Pesticides

The Relationship between Pesticide Exposure and Umbilical Serum IGF-1 Levels and Low-birth Weight: A Case-control Study in Brebes, Indonesia.

Potentially Toxic Elements

Toward ‘element balance’ in ADHD: an exploratory case control study employing hair analysis.

Levels of Macro- and Trace Elements and Select Cytokines in the Semen of Infertile Men.

Air Pollution

Association between short-term exposure to air pollution and ischemic stroke onset: a time-stratified case-crossover analysis using a distributed lag nonlinear model in Shenzhen, China.

Association of Ambient and Household Air Pollution With Bone Mineral Content Among Adults in Peri-urban South India.

Has the mortality risk declined after the improvement of air quality in an ex-heavily polluted Chinese city-Lanzhou?

Leukocyte Traits and Exposure to Ambient Particulate Matter Air Pollution in the Women’s Health Initiative and Atherosclerosis Risk in Communities Study.

Long-Term Exposure to Ambient Hydrocarbons Increases Dementia Risk in People Aged 50 years and above in Taiwan.

Wintertime Wood Smoke, Traffic Particle Pollution, and Preeclampsia and related, Ambient Air Pollution and Preeclampsia: Looking Back and Moving Forward.

Causal association between ambient ozone concentration and mortality in Seoul, Korea.

Source country-specific burden on health due to high concentrations of PM2.5.

Forecasting health effects potentially associated with the relocation of a major air pollution source.

Carcinogenic risk from exposure to PM2.5 bound polycyclic aromatic hydrocarbons in rural settings.

Accounting for measurement error to assess the effect of air pollution on omic signals. [methods/findings could be used for other chemicals also]

Miscellaneous

Maternal, Cord, and Three-Year-Old Child Serum Thyroid Hormone Concentrations in the Health Outcomes and Measures of the Environment (HOME) Study.

Laboratory Studies

BPA/Phenols

Acute and sub-acute bisphenol-B exposures adversely affect sperm count and quality in adolescent male mice.

Global liver proteomic analysis of Wistar rats chronically exposed to low-levels of bisphenol A and S.

Phthalates

Late-Life Consequences of Short-Term Exposure to Di(2-ethylhexyl) Phthalate and Diisononyl Phthalate During Adulthood in Female Mice.

Perfluoroalkyl Substances

Immunotoxicity and allergenic potential induced by topical application of perfluorooctanoic acid (PFOA) in a murine model.

Flame Retardants

Neonatal exposure to organophosphorus flame retardant TDCPP elicits neurotoxicity in mouse hippocampus via microglia-mediated inflammation in vivo and in vitro.

Rno-miR-224-5p contributes to 2,2′,4,4′-tetrabromodiphenyl ether-induced low triiodothyronine in rats by targeting deiodinases.

Potentially Toxic Elements

Protective role of glutamine against cadmium-induced testicular dysfunction in Wistar rats: Involvement of G6PD activity.

Euterpe oleracea (Martius) Oil Reverses Testicular Alterations Caused after Cadmium Administration.

In vitro and bioinformatics mechanistic-based approach for cadmium carcinogenicity understanding.

Effects of cadmium on the gene transcription of the liver in the freshwater turtle (Chinemys reevesii).

Arsenic-related oxidative stress in experimentally-dosed wild great tit nestlings.

Arsenic (III) or/and copper (II) exposure induce immunotoxicity through trigger oxidative stress, inflammation and immune imbalance in the bursa of chicken.

Physiological and histopathological responses of Porcellio laevis (Isopoda, Crustacea) as indicators of metal trace element contamination.

Potential use of morphological deformities in Chironomus (Diptera: Chironomidae) as a bioindicator of heavy metals pollution in North-East Algeria.

Microplastics

Exposure to polystyrene microplastics causes reproductive toxicity through oxidative stress and activation of the p38 MAPK signaling pathway.

Hepatotoxicity of pristine polyethylene microplastics in neotropical physalaemus cuvieri tadpoles (Fitzinger, 1826).

Air Pollution

Hazardous effects of urban air particulate matter acute exposure on lung and extrapulmonary organs in mice.

Pharmaceuticals

The progestin norethindrone alters growth, reproductive histology and gene expression in zebrafish (Danio rerio).

Mixtures

Neurotoxicity, Behavior, and Lethal Effects of Cadmium, Microplastics, and Their Mixtures on Pomatoschistus microps Juveniles from Two Wild Populations Exposed under Laboratory Conditions-Implications to Environmental and Human Risk Assessment.

Influence of silica nanoparticles on cadmium-induced cytotoxicity, oxidative stress, and apoptosis in human liver HepG2 cells.

Miscellaneous

Terrestrial toxicity of synthetic gas-to-liquid (GTL) versus crude oil-derived drilling fluids in soil.

Complex epigenetic patterns in cerebellum generated after developmental exposure to trichloroethylene and/or high fat diet in autoimmune-prone mice.

Subcellular Organelle Toxicity Caused by Arsenic Nanoparticles in Isolated Rat Hepatocytes.

Decreased malondialdehyde levels in fish (Astyanax altiparanae) exposed to diesel: Evidence of metabolism by aldehyde dehydrogenase in the liver and excretion in water.

Exposure/Environment Studies

Phthalates

Pollution characteristics of phthalate acid esters in agricultural soil of Yinchuan, northwest China, and health risk assessment.

Phthalic acid esters in the sea-surface microlayer, seawater and sediments of the East China Sea: Spatiotemporal variation and ecological risk assessment.

Analysis of phthalic acid esters in agricultural soils.

Perfluoroalkyl Substances

Indoor exposure to per- and polyfluoroalkyl substances (PFAS) in the childcare environment.

Contamination profiles and risk assessment of per- and polyfluoroalkyl substances in groundwater in China.

Perfluorinated substances in the Flemish population (Belgium): Levels and determinants of variability in exposure.

Role of the air-water interface in removing perfluoroalkyl acids from drinking water by activated carbon treatment.

A Matrix-Correction Approach to Estimate the Bioaccumulation Potential of Emerging PFASs.

Flame Retardants

Occurrence and distribution of organophosphate esters in sediment from northern Chinese coastal waters.

Evaluation of the OECD POV and LRTP screening tool for estimating the long-range transport of organophosphate esters.

Retention of polybrominated diphenyl ethers and hydroxylated metabolites in paired human serum and milk in relation to CYP2B6 genotype.

Pesticides

Exposure and potential effects of pesticides and pharmaceuticals in protected streams of the US National park Service southeast region.

Effect of Body Composition and Energy Expenditure on Permethrin Biomarker Concentrations among US Army National Guard Members.

Mitigation of organophosphate pesticide pollution in agricultural watersheds.

Potentially Toxic Elements

Selenium Bioaccumulation Across Trophic Levels and Along a Longitudinal Gradient in Headwater Streams.

Health risk assessment of heavy metals and pesticides: A case study in the main drinking water source in Dalian, China.

Changes in heavy metal accumulation in some edible landscape plants depending on traffic density.

Content and dietary exposure of cadmium among residents in Northeast China: a case study based on the 5th China Total Diet Study.

Concentrations of some heavy metal and macroelements in sediment, water, macrophyte species, and leech (Hirudo sulukii n. sp.) from the Kara Lake, Adiyaman, Turkey.

Assessment of heavy metal contamination in natural waters of Dereli, Giresun: an area containing mineral deposits in northeastern Turkey.

Evaluating temporal patterns of metals concentrations in floodplain lakes of the Athabasca Delta (Canada) relative to pre-industrial baselines.

Impact assessment of metals on soils from Machu Picchu archaeological site.

Estimation of cadmium load from soybeans and soy-based foods for vegetarians.

Quantitative analysis of lead in cows and buffaloes for health assessment.

Wetland water-management may influence mercury bioaccumulation in songbirds and ducks at a mercury hotspot.

Shifts in mercury methylation across a peatland chronosequence: From sulfate reduction to methanogenesis and syntrophy.

Trace metal effects on gross primary productivity and its associative environmental risk assessment in a subtropical lake, China.

A follow-up study on the characterization and health risk assessment of heavy metals in ambient air particles emitted from a municipal waste incinerator in Zhejiang, China.

Arsenic: Geochemical distribution and age-related health risk in Italy.

Microplastics

National reconnaissance survey of microplastics in municipal wastewater treatment plants in Korea.

Microplastic consumption and excretion by fathead minnows (Pimephales promelas): Influence of particles size and body shape of fish.

Greenhouse gas cycling by the plastisphere: The sleeper issue of plastic pollution.

Pharmaceuticals

Methamphetamine use in typical Chinese cities evaluated by wastewater-based epidemiology.

Occurrence of typical antibiotics in Nansi Lake’s inflowing rivers and antibiotic source contribution to Nansi Lake based on principal component analysis-multiple linear regression model.

[Occurrence Characteristics and Risk Assessment of Antibiotics in Source Water of the Nanjing Reach of the Yangtze River]. [Chinese]

PAHs

Formation of OSA and dispersion of polycyclic aromatic hydrocarbons in a tropical estuary as a tool in the prevention of environmental impacts: influence of the biogeochemical characteristics of the estuary.

Polycyclic aromatic hydrocarbons in urban Greenland soils of Nanjing, China: concentration, distribution, sources and potential risks.

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This list is not meant to be exhaustive, and generally does not include studies on detection, remediation, or treatment of EDCs. Note that journal publication dates may be different than dates added to PubMed. To see the searchable archives, please email me at Sarah@healthandenvironment.org and ask to join the group EDC_research@googlegroups.com. Archives are at https://groups.google.com/d/forum/edc_research. Compiled by Sarah Howard, Diabetes and Environment Program and HEEDS at Commonweal.

EHN EHN

Endocrine-disrupting chemicals: hazards and opportunities (ECHO) course
by Sarah Howard on October 31, 2024 at 2:50 pm
This course focuses on the chemical, biological, and societal challenges of endocrine-disrupting chemicals (EDCs) and new opportunities for moving forward. ECHO is a two-week intensive bootcamp-style career development course for graduate students, postdoctoral fellows, and professionals in the field. It is held at Woods Hole, Massachusetts.
Lou Guillette Jr. Memorial Symposium
by Sarah Howard on October 22, 2024 at 1:30 pm
On March 14-15, 2025, HEEDS is hosting the Lou Guillette Jr. Memorial Symposium on endocrine disrupting science at the University of Florida. It will celebrate the life and legacy of Dr. Guillette, gather together his trainees and colleagues, and focus on the research topics that Lou made famous. Information here.
Webinar: The overturning of Chevron deference: impacts on environmental health decision making
by Sarah Howard on October 17, 2024 at 4:21 pm
In this Nov. 13 webinar, legal experts will discuss the implications of the overturning of Chevron deference and its profound impact on science, public health and decision-making. Sponsored by CHE and UCSF's EaRTH Center.

EHN EHN

Ultra-processed foods and plastic packaging make for the ultimate toxic pair, scientists say
by Katherine McMahon,Sarah Howard on October 25, 2024 at 10:37 am
A recent paper published in Globalization and Health explores the relationship between ultra-processed foods (UPFs), plastic packaging, and their combined threat to public health. “Consumers do not have the power to solve a problem of this scale, and thus it is the responsibility of policymakers to ensure that transitions away from unhealthy, unsustainable foods are accompanied by structural measures that support demand and access to healthy foods.”
Microplastic exposure linked to reduced sperm quality in humans
by Katherine McMahon,Sarah Howard on October 23, 2024 at 4:29 pm
Exposure to microplastics is associated with a decrease in sperm concentration, motility, and shape, according to a new study published in The Lancet. “The identification of non-stick pan coating material PTFE as a particularly hazardous microplastic for male fertility underscores the importance of targeted interventions to reduce exposure to this and similar substances.”
Exposure to PFAS in ski wax may be linked to high cholesterol
by Katherine McMahon,Sarah Howard on October 16, 2024 at 7:42 pm
According to a new study published in Environmental Research, skiers and snowboarders may face health risks from their exposure to PFAS via ski wax, which can contain up to 100% PFAS by mass. “Interventions to remove PFAS from fluorinated wax could decrease direct exposure to skiers and reduce PFAS release into the environment.”

EHN EHN

Stricter toxic chemical rules reduce Californians’ exposures
by Kristina Marusic on October 31, 2024 at 11:25 am
Californians have lower levels of toxic chemicals linked to cancer, birth defects and reproductive harm in their bodies than people in the rest of the country, according to a new study. The study, published in Environmental Health Perspectives and conducted by researchers at Silent Spring Institute, a nonprofit scientific research organization, and the University of California at Berkeley (UC Berkeley), looked at nationwide data on the levels of 37 toxic chemicals in people’s blood before and after California introduced its stringent regulations. It found that for 18 of these chemicals, Californians have lower levels in their bodies than the rest of the country.
EPA dismissed data on the neurotoxicity of common insecticides
by Katherine McMahon,Sarah Howard on October 30, 2024 at 5:56 pm
A recent paper in Frontiers in Toxicology examined research submitted by industry to the U.S. Environmental Protection Agency (EPA) on the neurotoxicity of neonicotinoids - the most widely used class of insecticides in the U.S. and worldwide - and found that the data was evaluated improperly by the agency. Why this matters: Neonicotinoids are widely used not only for commercial agriculture but also for more personal uses like home gardens and in some flea and tick treatments for pets. Humans are regularly exposed to neonicotinoids – which are structurally similar to nicotine – through the environment, food and water. Neonicotinoids’ popularity partly comes from the belief that their harmful effects are mostly limited to insects, but studies like this one demonstrate that mammals may also be harmed by the chemicals, and highlight the urgent need for stronger regulations around their use.
Pesticide regulations ignore critical threats to insect health and ecosystems
by EHN Curators on October 30, 2024 at 10:26 am
In a study revealing regulatory gaps, researchers found that pesticides impact insect behavior and survival at non-lethal doses, especially in warmer temperatures, calling into question the effectiveness of current pesticide safety protocols. Dave Goulson writes for The Conversation.