EDC Science Weekly, Dec. 18 – 21, 2019 – HEEDS

EDC Science Weekly, Dec. 18 – 21, 2019

Post author:HEEDS
Post published:December 21, 2019
Post category:EDC Science Weekly

A summary of articles on endocrine disrupting chemicals (EDCs) added to PubMed this week.

(This is a short summary this week and then look for a longer summary in January! Happy Holidays!)

Contents: Methods/Screening, Reviews, Human Health Studies, Laboratory Studies, Exposure/Environment Studies.

Methods/Screening

Identifying and Prioritizing Chemicals with Uncertain Burden of Exposure: Opportunities for Biomonitoring and Health-Related Research.

Toxicity testing in the 21st century: progress in the past decade and future perspectives.

New Perspectives for Cancer Hazard Evaluation by the Report on Carcinogens: A Case Study Using Read-Across Methods in the Evaluation of Haloacetic Acids Found as Water Disinfection By-Products.

Exploring mechanistic toxicity of mixtures using PBPK modeling and computational systems biology.

Exploring QSAR modeling of toxicity of chemicals on earthworm.

Reviews

Commentaries/Conference Summaries

Editorial: Organotins as a Complete Physiologic and Endocrine Disruptor: Role of Disease Development. This is part of a research topic on this subject, available here.

Multiple chemical sensitivity: pursuit of a scientific consensus, need for a public health response. Commentary.

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

The association between prenatal exposure to organochlorine compounds and neonatal thyroid hormone levels: a systematic review.

Flame Retardants

Tetrabromobisphenol A: Disposition, kinetics and toxicity in animals and humans

Pesticides

Impact of chlorpyrifos on blood glucose concentration in an animal model: a systematic review and meta-analysis.

Potentially Toxic Elements

Developmental fluoride neurotoxicity: an updated review.

Air Pollution

Air Pollution (Particulate Matter) Exposure and Associations with Depression, Anxiety, Bipolar, Psychosis and Suicide Risk: A Systematic Review and Meta-Analysis.

Environmental Exposures and Asthma Development: Autophagy, Mitophagy, and Cellular Senescence.

PM2.5, Fine Particulate Matter: A Novel Player in the Epithelial-Mesenchymal Transition?

Interventions to reduce ambient air pollution and their effects on health: An abridged Cochrane systematic review.

The relationship between exposure to particulate matter and breast cancer incidence and mortality: A meta-analysis.

Miscellaneous

Impact of environmental contaminants on reproductive health of male domestic ruminants: a review. [numerous EDCs]

The Microbiome-Estrogen Connection and Breast Cancer Risk. ‘

Carcinogenicity assessment: Addressing the challenges of cancer and chemicals in the environment

Human Health Studies

BPA/Phenols

Urine Bisphenol A and Arsenic Levels in Residents of the Cheyenne River Sioux Tribe, South Dakota, with and without Diabetes.

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

Hypertension in Relation to Dioxins and Polychlorinated Biphenyls from the Anniston Community Health Survey Follow-Up.

Pesticides

Organophosphate Pesticide Exposures and Menstrual Cycle Characteristics in Chinese Preconception Women.

Increased levels of genotoxic damage in a Bolivian agricultural population exposed to mixtures of pesticides.

Potentially Toxic Elements

Prenatal exposure to metal mixture and sex-specific birth outcomes in the New Hampshire Birth Cohort Study.

Reproductive outcomes in pregnant women and its association with arsenic contamination in drinking water, in a region characterized by high birth weight rates in Peru.

Arsenic and Gallbladder Cancer Risk: Mendelian Randomization Analysis of European Prospective Data. [letter]

Air Pollution

Adverse Effects of Exposure to Fine Particulate Matters and Ozone on Gestational Hypertension.

Association of Prenatal and Perinatal Exposures to Particulate Matter With Changes in Hemoglobin A1c Levels in Children Aged 4 to 6 Years.

The effects of occupational pollutants on the reproductive health of female informal street traders in Warwick junction, Durban, South Africa – a cross-sectional study.

Effect of air pollution on hospitalization for acute exacerbation of chronic obstructive pulmonary disease, stroke, and myocardial infarction.

Particulate matter air pollution and the expression of microRNAs and pro-inflammatory genes: Association and mediation among children in Jinan, China.

Cause and Age-specific premature mortality attributable to PM2.5 Exposure: An analysis for Million-Plus Indian cities.

The association between high particulate matter pollution and daily cause-specific hospital admissions: a time-series study in Yichang, China.

Long-term exposure to ozone and children’s respiratory health: Results from the RESPOZE study.

Increase in Pediatric Respiratory Visits Associated with Santa Ana Wind-driven Wildfire Smoke and PM2.5 Levels in San Diego County.

Miscellaneous

Qualitative Assessment of Environmental Health Risk Perceptions and Community Challenges in a Puerto Rican Community: Change and Continuity in Response to Hurricanes Irma and María.

When Do Governments Support Common Goods for Health? Four Cases on Surveillance, Traffic Congestion, Road Safety, and Air Pollution.

Laboratory Studies

BPA/Phenols

The Mechanism of Bisphenol A Atherogenicity Involves Apolipoprotein A-I Downregulation through NF-κB Activation.

Antioxidant CoQ10 Restores Fertility by Rescuing Bisphenol A-Induced Oxidative DNA Damage in the Caenorhabditis elegans Germline.

Bisphenol A-induced oxidative damage in the hepatic and cardiac tissues of rats: The modulatory role of sesame lignans.

Protective Action of Eruca sativa Leaves Aqueous Extracts Against Bisphenol A-Caused In Vivo Testicular Damages.

Bioaccumulation investigation of bisphenol A in HepG2 cells and zebrafishes enabled by cobalt magnetic polystyrene microsphere derived carbon based magnetic solid-phase extraction.

Phthalates

Glycerin Monostearate Aggravates Male Reproductive Toxicity Caused by Di(2-ethylhexyl) Phthalate in Rats.

Di(2-ethylhexyl) phthalate inhibits glutathione regeneration and dehydrogenases of the pentose phosphate pathway on human colon carcinoma cells.

Aneugenic, clastogenic, and multi-toxic effects of diethyl phthalate exposure.

Development, Testing, Parameterization, and Calibration of a Human Physiologically Based Pharmacokinetic Model for the Plasticizer, Hexamoll® Diisononyl-Cyclohexane-1, 2-Dicarboxylate Using In Silico, In Vitro, and Human Biomonitoring Data. [a phthalate alternative]

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

Halogen Bonding Interactions of Polychlorinated Biphenyls and the Potential for Thyroid Disruption.

Folic acid supplementation reduces multigenerational sperm miRNA perturbation induced by in utero environmental contaminant exposure.

Perfluoroalkyl Substances

SAM targeting methylation by the methyl donor, a novel therapeutic strategy for antagonize PFOS transgenerational fertilitty toxicity.

Phytotoxicity induced by perfluorooctanoic acid and perfluorooctane sulfonate via metabolomics.

Organotins

Protective Effects of Scolopendra Water Extract on Trimethyltin-Induced Hippocampal Neurodegeneration and Seizures in Mice.

Pesticides

Nitenpyram disturbs gut microbiota and influences metabolic homeostasis and immunity in honey bee (Apis mellifera L.).

Hepatoprotective role of berberine against paraquat-induced liver toxicity in rat.

Acute thiamethoxam toxicity in honeybees is not enhanced by common fungicide and herbicide and lacks stress-induced changes in mRNA splicing.

Toxicity risk assessment of pyriproxyfen and metabolites in the rat liver: A vitro study.

Humoral immune responses and gill antioxidant-related gene expression of common carp (Cyprinus carpio) exposed to lufenuron and flonicamide.

Fungicide suppression of flight performance in the honeybee (Apis mellifera) and its amelioration by quercetin.

Integrated gender-related effects of profenofos and paclobutrazol on neurotransmitters in mouse.

Toxicity to Rhinella arenarum tadpoles (Anura, Bufonidae) of herbicide mixtures commonly used to treat fallow containing resistant weeds: glyphosate-dicamba and glyphosate-flurochloridone.

Impairment of testicular development in rats exposed to acephate during maternal gestation and lactation.

Female preference and adverse developmental effects of glyphosate-based herbicide on ecologically relevant traits in Japanese quails.

Effects of brodifacoum and diphacinone exposure on four species of reptiles: Tissue residue levels and survivorship.

Impact of Diflubenzuron on Bombus impatiens (Hymenoptera: Apidae) Microcolony Development.

Potentially Toxic Elements

In vivo evaluation of arsenic-associated behavioral and biochemical alterations in F0 and F1 mice.

Low concentrations of sodium arsenite induce hepatotoxicity in prepubertal male rats.

Toxic effects of arsenic trioxide on spermatogonia are associated with oxidative stress, mitochondrial dysfunction, autophagy and metabolomic alterations.

Deregulation of autophagy is involved in nephrotoxicity of arsenite and fluoride exposure during gestation to puberty in rat offspring.

High level of methylmercury exposure causes persisted toxicity in Nauphoeta cinerea.

Inactivation of GAP-43 due to the depletion of cellular calcium by the Pb and amyloid peptide induced toxicity: An in vitro approach.

Acute Methylmercury Exposure and the Hypoxia-Inducible Factor-1α Signaling Pathway under Normoxic Conditions in the Rat Brain and Astrocytes in Vitro.

Cadmium and Lead Decrease Cell-Cell Aggregation and Increase Migration and Invasion in Renca Mouse Renal Cell Carcinoma Cells.

The mixture toxicity of heavy metals on Photobacterium phosphoreum and its modeling by ion characteristics-based QSAR.

Zinc interference with Cd-induced hormetic effect in differentiated Caco-2 cells: Evidence for inhibition downstream ERK activation.

Microplastics

Microplastic (1 and 5 μm) exposure disturbs lifespan and intestine function in the nematode Caenorhabditis elegans.

Air Pollution

Neuronal and perineuronal changes of cerebral cortex after exposure to inhaled particulate matter.

Mixtures

Metabolic profiling of Daphnia magna exposure to a mixture of hydrophobic organic contaminants in the presence of dissolved organic matter.

Impact of binary waterborne mixtures of nickel and zinc on hypothalamic-pituitary-testicular axis in rats.

Treated Textile Effluents: Cytotoxic and Genotoxic Effects in the Natural Aquatic Environment.

Miscellaneous

Integrative assessment of low-dose gamma radiation effects on Daphnia magna reproduction: Toxicity pathway assembly and AOP development. [includes endocrine disruption]

Exposure to humidifier disinfectants induces developmental effects and disrupts thyroid endocrine systems in zebrafish larvae.

Exposure/Environment Studies

Phthalates

Phthalates in the NICU: a survey.

Feminine Hygiene Products-A Neglected Source of Phthalate Exposure in Women.

Occurrence and Concentration of Chemical Additives in Consumer Products in Korea.

Parabens/Triclosan/Antimicrobials

Exposure to triclosan among pregnant women in northern China: urinary concentrations, sociodemographic predictors, and seasonal variability.

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

A screening of select toxic and essential elements and persistent organic pollutants in the fur of Svalbard reindeer.

Evidence for major contributions of unintentionally-produced PCBs in the air of China: implications for the national source inventory.

Concentration levels and carcinogenic and mutagenic risks of PM2.5-bound polycyclic aromatic hydrocarbons in an urban-industrial area in South Africa.

PAHs in road dust of Nanjing Chemical Industry Park, China: chemical composition, sources, and risk assessment.

Pesticides

Effects of processing and storage on pesticide residues in foods. [review]

Spatial distribution of agricultural pesticide use and predicted wetland exposure in the Canadian Prairie Pothole Region.

Histopathological alterations in gills of a fish (Astyanax bifasciatus) in neotropical streams: negative effects of riparian forest reduction and presence of pesticides.

Potentially Toxic Elements

Ingestion and inhalation of metal(loid)s through preschool gardening: An exposure and risk assessment in legacy mining communities.

A dietary assessment tool to estimate arsenic and cadmium exposures from locally grown foods.

Characteristics and health risk assessment of heavy metals in street dust for children in Jinhua, China.

Trace metal trophic transference and biomagnification in a semiarid coastal lagoon impacted by agriculture and shrimp aquaculture.

Effect of different elemental chlorine-free bleaching sequences on pulp, effluent properties and their impact on index of global pollution.

Trace metal biomonitoring in the east Gippsland Lakes estuary using the barnacle Amphibalanus variegatus and mussel Mytilus edulis.

Natural versus anthropogenic influence on trace elemental concentration in precipitation at Dokriani Glacier, central Himalaya, India.

Are oil spills an important source of heavy metal contamination in the Bohai Sea, China?

Concentration of trace metals in winter wheat and spring barley as a result of digestate, cattle slurry, and mineral fertilizer application.

Seasonal influences on swimming crab mercury levels in an eutrophic estuary located in southeastern Brazil.

Heavy Metals Can either Aid or Oppose the Protective Function of the Placental Barrier.

Occurrence of trace metals in food crops grown on the Mbale dumpsite, Uganda and human health risks.

Levels and ecological and health risk assessment of PM2.5-bound heavy metals in the northern part of the Persian Gulf.

Contamination by As, Hg, and Sb in a region with geogenic As anomaly and subsequent human health risk characterization.

Arsenic and cadmium as predominant factors shaping the distribution patterns of antibiotic resistance genes in polluted paddy soils.

Concentration and Risk Assessment of Potentially Toxic Elements, Lead and Cadmium, in Vegetables and Cereals Consumed in Western Iran.

Advanced determination of the spatial gradient of human health risk and ecological risk from exposure to As, Cu, Pb, and Zn in soils near the Ventanas Industrial Complex (Puchuncaví, Chile).

Physical, Chemical, and Biological Factors that Contribute to the Variability of Mercury Concentrations in Largemouth Bass Micropterus salmoides from Missouri Reservoirs.

Temporal-spatial trends in potentially toxic trace element pollution in farmland soil in the major grain-producing regions of China.

Microplastics

Microplastic analysis-are we measuring the same? Results on the first global comparative study for microplastic analysis in a water sample.

Microplastics and seafood: lower trophic organisms at highest risk of contamination.

Microplastics in agricultural soils on the coastal plain of Hangzhou Bay, east China: Multiple sources other than plastic mulching film.

Distribution and characterization of microplastic particles and textile microfibers in Adriatic food webs: General insights for biomonitoring strategies.

A nationwide assessment of litter on China’s beaches using citizen science data.

Air Pollution

Connecting Air Pollution Exposure to Socioeconomic Status: A Cross-Sectional Study on Environmental Injustice among Pregnant Women in Scania, Sweden.

Inventory of polychlorinated naphthalene emissions from waste incineration and metallurgical sources in China.

Pharmaceuticals

Pharmaceuticals residues and xenobiotics contaminants: Occurrence, analytical techniques and sustainable alternatives for wastewater treatment.

Effects of industrial effluents containing moderate levels of antibiotic mixtures on the abundance of antibiotic resistance genes and bacterial community composition in exposed creek sediments.

Mixtures

Hidden Costs in the Physiology of Argia anceps (Zigoptera: Coenagrionidae) due to Pollution. [pollution from mines and agriculture]

Sources, presence and potential effects of contaminants of emerging concern in the marine environments of the Great Barrier Reef and Torres Strait, Australia. [review; antifouling paints; coal dust and particles; heavy metals and metalloids; marine debris and microplastics; pharmaceuticals and personal care products; and petroleum hydrocarbons]

Miscellaneous

Short- and medium-chain chlorinated paraffins in plastic animal feed packaging and factors affect their migration into animal feed.

Assessing UV filter inputs into beach waters during recreational activity: A field study of three French Mediterranean beaches from consumer survey to water analysis.

Selected harmful and potentially harmful constituents levels in commercial e-cigarettes.

There are also numerous articles in the journal Huan Jing Ke Xue in Chinese (with English abstracts) on various environmental chemicals (largely heavy metals) just added to PubMed, available here.

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This list is not meant to be exhaustive, and generally does not include studies on detection, remediation, or treatment of EDCs. Note that journal publication dates may be different than dates added to PubMed. To see the searchable archives, please email me at Sarah@healthandenvironment.org and ask to join the group EDC_research@googlegroups.com. Archives are at https://groups.google.com/d/forum/edc_research. Compiled by Sarah Howard, Diabetes and Environment Program and HEEDS at Commonweal.

EHN EHN

Webinar: Fluoride, neurodevelopment, and cognition: a National Toxicology Program monograph
by Sarah Howard on November 19, 2024 at 5:00 pm
This Dec. 3 webinar features Dr. Kyla Taylor of NIEHS who will discuss the results of a National Toxicology Program monograph review that concluded there is "moderate confidence" in the scientific evidence that showed an association between higher levels of fluoride exposure and lower IQ in children.
Webinar: Behind the scenes at EPA: What's gone wrong and what does it mean for our work?
by Sarah Howard on November 19, 2024 at 3:56 pm
This Dec. 9 webinar, Behind the scenes at EPA: what's gone wrong and what does it mean for our work? is part 2 of a series on the future of EPA decision-making. Sponsored by the Collaborative for Health and Environment (CHE), Earthjustice, and UCSF's Earth Center.
Endocrine-disrupting chemicals: hazards and opportunities (ECHO) course
by Sarah Howard on October 31, 2024 at 2:50 pm
This course focuses on the chemical, biological, and societal challenges of endocrine-disrupting chemicals (EDCs) and new opportunities for moving forward. ECHO is a two-week intensive bootcamp-style career development course for graduate students, postdoctoral fellows, and professionals in the field. It is held at Woods Hole, Massachusetts.

EHN EHN

“We have enough evidence” to act on toxic plastic exposure now
by Katherine McMahon,Sarah Howard on November 22, 2024 at 3:31 pm
In a recent commentary published in The Lancet, Dr. Leonardo Trasande of NYU’s Grossman School of Medicine emphasizes the need to address the well-established health harms from exposure to chemical additives used in plastics. “Only through a serious and concerted effort to turn off the plastic tap will we apply the lessons learned from plastic use… and avoid the invisible chemicals used in plastic materials from becoming visible in the form of a larger global pandemic of chronic disease.”
Kids who adopt a gluten-free diet have increased arsenic levels
by Katherine McMahon,Sarah Howard on November 20, 2024 at 1:32 pm
A recent study published in The American Journal of Gastroenterology found that children who adopted a gluten-free (GF) diet after being diagnosed with celiac disease had significantly increased arsenic exposure after only six months. “More research needs to be done to determine whether there are long-term effects of this bump, but overall, I think it speaks to the importance of diversifying the grains in the gluten-free diet.”
NIEHS publishes new strategic plan
by Sarah Howard on November 19, 2024 at 6:03 pm
The National Institute of Environmental Health Sciences (NIEHS) published a 2025-2029 strategic plan, "Health at the Intersection of People and Their Environments."

EHN EHN

Trump’s second term could mean fewer protections for drinking water
by EHN Curators on November 21, 2024 at 12:30 pm
Donald Trump’s plans for the Environmental Protection Agency may include rolling back protections against PFAS and other drinking water threats, worrying public health advocates. Hiroko Tabuchi reports for The New York Times.
Kennedy’s fluoride policy faces obstacles
by EHN Curators on November 19, 2024 at 8:28 pm
President-elect Trump’s selection of Robert F. Kennedy Jr. to lead the Department of Health and Human Services won’t give him direct control over water fluoridation policies, though his influence could sway public and local debates. Miranda Willson reports for E&E News.
Scientists' Declaration for the Global Plastics Treaty
by Sarah Howard on November 19, 2024 at 5:54 pm
The signatories of this declaration are independent scientists with expertise on plastics, and who are free of conflicts of interest associated with the life cycle of plastics. Read it here and sign it here. Due Nov. 22, 2024.