EDC Science Weekly: Nov. 6-12, 2019 – HEEDS

EDC Science Weekly: Nov. 6-12, 2019

Post author:HEEDS
Post published:November 12, 2019
Post category:EDC Science Weekly

A summary of articles on endocrine disrupting chemicals (EDCs) added to PubMed this week.

Contents: Methods/Screening, Reviews, Human Health Studies, Laboratory Studies, Human Exposure Studies, Wildlife/Environment Studies.

Methods/Screening

The Use and Misuse of Historical Controls in Regulatory Toxicology: Lessons from the CLARITY-BPA Study.

Historical control data for the interpretation of ecotoxicology data; Are we missing a trick? [an industry perspective]

An integrative method for identification and prioritization of constituents of concern in produced water from onshore oil and gas extraction.

Bisphenol A binding promiscuity: A virtual journey through the universe of proteins.

Fluorescent reporter zebrafish line for estrogenic compound screening generated using a CRISPR/Cas9-mediated knock-in system.

Extrapolating In Vitro Screening Assay Data for Thyroperoxidase Inhibition to Predict Serum Thyroid Hormones in the Rat.

Three-dimensional (3D) brain microphysiological system for organophosphates and neurochemical agent toxicity screening.

Novel text analytics approach to identify relevant literature for human health risk assessments: A pilot study with health effects of in utero exposures.

Reviews

Commentaries/Workshop Summaries

Statement on advancing the assessment of chemical mixtures and their risks for human health and the environment.

How can the integrity of occupational and environmental health research be maintained in the presence of conflicting interests? [read this one!]

Mitochondrial Toxins and Healthy Lifestyle Meet at the Crossroad of Hormesis. [POPs and metals; interesting ideas]

State of the science on alternatives to animal testing and integration of testing strategies for food safety assessments: Workshop proceedings.

Eighth Annual Conference of inVIVO Planetary Health: From Challenges to Opportunities.

Air Pollution: an environmental risk factor for psychiatric illness?

BPA/Phenols

Association between prenatal exposure to bisphenol a and birth outcomes: A systematic review with meta-analysis.

Hazards of bisphenol A (BPA) exposure: A systematic review of plant toxicology studies.

Pesticides

Analysis of global trends and gaps for studies about 2,4-D herbicide toxicity: A scientometric review.

Drosophila melanogaster as a powerful tool for studying insect toxicology.

An overview of the potential impacts of atrazine in aquatic environments: Perspectives for tailored solutions based on nanotechnology.

Modifiable risk and protective factors in disease development, progression and clinical subtypes of Parkinson’s disease: What do prospective studies suggest?

Properties, toxicity and current applications of the biolarvicide spinosad.

Arsenic/Metals

Endoplasmic Reticulum Stress Induced by Toxic Elements-a Review of Recent Developments.

Cadmium in Human Diseases: It’s More than Just a Mere Metal.

Biometals as Potential Predictors of the Neurodegenerative Decline in Alzheimer’s Disease.

Pharmaceuticals

Ibuprofen Safety at the Golden Anniversary: Are all NSAIDs the Same? A Narrative Review.

Mixtures

A systematic review and meta-analysis examining the interrelationships between chemical and non-chemical stressors and inherent characteristics in children with ADHD

The effect of expsoure to crude oil on the immune system. Health implications for people living near oil exploration activities.

Miscellaneous

Cheminformatics Explorations of Natural Products.

Can adoption of pollution prevention techniques reduce pollution substitution?

Human Health Studies

Phthalates

The associations of urinary phthalate metabolites with the intermediate and pregnancy outcomes of women receiving IVF/ICSI treatments: A prospective single-center study.

The effects of di(2-ethylhexyl) phthalate exposure in women with polycystic ovary syndrome undergoing in vitro fertilization.

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

Mobilization of Environmental Toxicants Following Bariatric Surgery. [PCBs, OCPs, PBDEs, PFAS]

Influence of dioxin-related compounds on physical function in Yusho incident victims.

A longitudinal study of polychlorinated biphenyls and neuropsychological function among older adults from New York State.

Perfluoroalkyl Substances

Association between perfluoroalkyl acids and liver function: Data on sex differences in adolescents.

Pesticides

More pesticides-less children? [great title by the way]

Multiple pesticides in mothers’ hair samples and children’s measurements at birth: Results from the French national birth cohort (ELFE).

Geographic distribution and environmental risk factors of lymphoma in dogs under primary-care in the UK. [ok dogs aren’t humans but practically so…]

Arsenic/Metals

Pregnancy exposome and child psychomotor development in three European birth cohorts.

Exposure to low-dose arsenic in early life alters innate immune function in children.

Blood metal levels and serum testosterone concentrations in male and female children and adolescents: NHANES 2011-2012.

Blood levels of endocrine-disrupting metals and prevalent breast cancer among US women.

Thyroid dysfunction: how concentration of toxic and essential elements contribute to risk of hypothyroidism, hyperthyroidism, and thyroid cancer.

Prenatal and postnatal cadmium exposure and cellular immune responses among pre-school children.

Relation between in utero arsenic exposure and growth during the first year of life in a New Hampshire pregnancy cohort.

Lessons from an early-stage epidemiological study on Minamata disease.

Air Pollution

Effect of PM2.5 on macrosomia in China: A nationwide prospective cohort study.

Air Pollution as a Cause of Obesity: Micro-Level Evidence from Chinese Cities.

Increased Dementia Mortality in West Virginia Counties with Mountaintop Removal Mining?

Associations between ambient air pollution and cancer incidence in Taiwan: an ecological study of geographical variations.

Cancer risk from air toxics in relation to neighborhood isolation and sociodemographic characteristics: A spatial analysis of the St. Louis metropolitan area, USA.

Sex differences in the interaction of short-term particulate matter exposure and psychosocial stressors on C-reactive protein in a Puerto Rican cohort.

Dynamic Linkages among Economic Development, Energy Consumption, Environment and Health Sustainable in EU and Non-EU Countries.

Mixtures

Examining environmental contaminant mixtures among adults with type 2 diabetes in the Cree First Nation communities of Eeyou Istchee, Canada. [of PCBs, OCPs, and metals, found DDT most important]

Interdisciplinary Approaches to Assessing the Health of People Living in Environmentally Adverse Conditions.

Miscellaneous

Repeated measures of urinary oxidative stress biomarkers and preterm birth in Puerto Rico.

Laboratory Studies

BPA/Phenols

Obesogen effect of bisphenol S alters mRNA expression and DNA methylation profiling in male mouse liver.

Juvenile toxicity rodent model to study toxicological effects of Bisphenol A (BPA) at dose levels derived from Italian children biomonitoring study.

Bisphenol A contamination in infant rats: molecular, structural, and physiological cardiovascular changes and the protective role of kefir.

Bisphenol S rapidly depresses heart function through estrogen receptor-β and decreases phospholamban phosphorylation in a sex-dependent manner.

Bisphenol S and Bisphenol A disrupt morphogenesis of MCF-12A human mammary epithelial cells.

Bisphenol F-induced neurotoxicity towards zebrafish embryos.

Inhibition of PPARγ by bisphenol A diglycidyl ether ameliorates dexamethasone-induced osteoporosis in a mouse model.

The toxic effects of Fluorene-9-bisphenol on porcine oocyte in vitro maturation. [a BPA substitute]

Phthalates

Prenatal low-dose DEHP exposure induces metabolic adaptation and obesity: Role of hepatic thiamine metabolism.

Knockdown of TNFAIP1 prevents di-(2-ethylhexyl) phthalate-induced neurotoxicity by activating CREB pathway.

SREBP2-STARD4 is involved in synthesis of cholesteryl ester stimulated by mono-butyl phthalate in MLTC-1 cells.

Parabens/Triclosan/Antimicrobials

Triclocarban impairs autophagy in neuronal cells and disrupts estrogen receptor signaling via hypermethylation of specific genes.

Characterizing the potential estrogenic and androgenic activities of two disinfection byproducts, mono-haloacetic acids and haloacetamides, using in vitro bioassays.

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

Exposure to Aroclor 1254 differentially affects the survival of pancreatic β-cells and α-cells in the male mice and the potential reason.

Technical-grade chlordane compromises rat Sertoli cells proliferation, viability and metabolic activity.

Impact of pyrethroids and organochlorine pesticides residue on IGF-1 and CYP1A genes expression and muscle protein patterns of cultured Mugil capito.

Perfluoroalkyl Substances

Binding specificities of estrogen receptor with perfluorinated compounds: A cross species comparison.

High-content screening in zebrafish identifies perfluorooctanesulfonamide as a potent developmental toxicant.

Perfluorooctane sulfonate disrupts the blood brain barrier through the crosstalk between endothelial cells and astrocytes in mice.

Perfluorooctanoic acid and perfluorooctane sulfonate co-exposure induced changes of metabolites and defense pathways in lettuce leaves.

Flame Retardants

Tetrabromoethylcyclohexane (TBECH) exhibits immunotoxicity in murine macrophages.

Polybrominated Diphenyl Ethers Quinone Induces NCOA4-mediated Ferritinophagy through Selectively Autophagic Degradation of Ferritin.

Single-cell RNA-sequencing analysis of estrogen- and endocrine-disrupting chemical-induced reorganization of mouse mammary gland. [PBDEs]

Organotins

Interaction of organotin compounds with three major glutathione S-transferases in zebrafish.

Tributyltin chloride (TBT) induces RXRA down-regulation and lipid accumulation in human liver cells.

Pesticides

Toxic effects of fluridone on early developmental stages of Japanese Medaka (Oryzias latipes).

Exposure to deltamethrin in adolescent mice induced thyroid dysfunction and behavioral disorders.

Risk and Toxicity Assessment of a Potential Natural Insecticide, Methyl Benzoate, in Honey Bees (Apis mellifera L.).

Exposure to diclofop-methyl induces immunotoxicity and behavioral abnormalities in zebrafish embryos.

Seasonal variations in the dose-response relationship of acetylcholinesterase activity in freshwater fish exposed to chlorpyrifos and glyphosate.

Maternal and fetal blood pharmacokinetics and organ distribution of atrazine, propazine, simazine and their metabolites in pregnant rats after chronic oral administration.

Pre-clinical evidence of safety and protective effect of isatin- and oxime-derivatives against malathion-induced toxicity.

Low doses of carbendazim and chlorothalonil synergized to impair mouse spermatogenesis through epigenetic pathways.

Gestational and Perinatal Exposure to Diazinon Causes Long-lasting Neurobehavioral Consequences in the Rat.

Sperm quality of rats exposed to difenoconazole using classical parameters and surface-enhanced Raman scattering: classification performance by machine learning methods.

Ameliorative Effect of Crocin on Sperm Parameters and In Vitro Fertilization in Mice under Oxidative Stress Induced by Paraquat.

Genotoxic and mutagenic evaluation of the protective effect of exogenous melatonin in adult rats and their offspring exposed to the insecticides methomyl and cypermethrin during pregnancy.

Arsenic/Metals

Metalloestrogenic effects of cadmium are absent in long-term estrogen-deprived MCF-7 cells: evidence for the involvement of constitutively activated estrogen receptor α and very low expression of G protein-coupled estrogen receptor 1.

Exposure to heavy metal-contaminated sediments disrupts gene expression, lipid profile, and life history traits in the midge Chironomus riparius.

MicroRNA-155 and microRNA-181a, via HO-1, participate in regulating the immunotoxicity of cadmium in the kidneys of exposed Cyprinus carpio.

Integrated transcriptomic and proteomic analyses of the tissues from the digestive gland of Chlamys farreri following cadmium exposure.

Curcumin Ameliorates Lead-Induced Hepatotoxicity by Suppressing Oxidative Stress and Inflammation, and Modulating Akt/GSK-3β Signaling Pathway.

Ecologically relevant arsenic exposure alters female mate preference and anxiety-like behavior in Betta splendens.

Effects of experimental lead exposure on physiological indices of nestling great tits Parus major: haematocrit and heterophile-to-lymphocyte ratio.

Examining the role of ethylenediaminetetraacetic acid (EDTA) in larval shellfish production in seawater contaminated with heavy metals.

Molecular responses of an estuarine oyster to multiple metal contamination in Southern China revealed by RNA-seq.

Alterations of NMDA and AMPA receptors and their signaling apparatus in the hippocampus of mouse offspring induced by developmental arsenite exposure.

Identification and profiling of microRNAs responsive to cadmium toxicity in hepatopancreas of the freshwater crab Sinopotamon henanense.

Microplastics

Exploring the impacts of plastics in soil – The effects of polyester textile fibers on soil invertebrates.

Accumulation of polybrominated diphenyl ethers and microbiome response in the great pond snail Lymnaea stagnalis with exposure to nylon (polyamide) microplastics.

Effects of accelerated aging on characteristics, leaching, and toxicity of commercial lead chromate pigmented microplastics.

Effects of nanoplastics at predicted environmental concentration on Daphnia pulex after exposure through multiple generations.

The mechanism for adsorption of Cr(VI) ions by PE microplastics in ternary system of natural water environment.

Developmental toxicity in zebrafish exposed to polyethylene microplastics under static and semi-static aquatic systems.

Air Pollution

Effects of early postnatal exposure to fine particulate matter on emotional and cognitive development and structural synaptic plasticity in immature and mature rats.

Pharmaceuticals

Effects of common pharmaceutical drugs (paracetamol and acetylsalicylic acid) short term exposure on biomarkers of the mussel Mytilus spp.

Mixtures

First evaluation of novel potential synergistic effects of glyphosate and arsenic mixture on Rhinella arenarum (Anura: Bufonidae) tadpoles.

Effects of a mixture of low doses of atrazine and benzo[a]pyrene on the rat seminiferous epithelium either during or after the establishment of the blood-testis barrier in the rat seminiferous tubule culture model.

Environmental polycyclic aromatic hydrocarbons mixture, in human blood levels, decreased oestradiol secretion by granulosa cells via ESR1 and GPER1 but not ESR2 receptor.

Effects of sublethal Cd, Zn, and mixture exposures on antioxidant defense and oxidative stress parameters in early life stages of the purple sea urchin Strongylocentrotus purpuratus.

Miscellaneous

In vitro exposure of vitellogenic rainbow trout ovarian follicles to endocrine disrupting chemicals can alter basal estradiol-17β production and responsiveness to a gonadotropin challenge.

Effects of chlorocholine chloride on pubertal development and reproductive functions in male rats.

Effect of Benzo(a)pyrene on the Expression of miR-483-3p in Hepatocyte Primary Culture and Rat Liver.

The surfactant polyethoxylated tallowamine (POEA) reduces lifespan and inhibits fecundity in Drosophila melanogaster- In vivo and in vitro study.

Genotoxic biomarkers and histological changes in marine medaka (Oryzias melastigma) exposed to 17α-ethynylestradiol and 17β-trenbolone.

Chronic simultaneous exposure of common carp (Cyprinus carpio) from embryonic to juvenile stage to drospirenone and gestodene at low ng/L level caused intersex.

Human Exposure Studies

Phthalates

Occurrence and distribution of phthalates in sanitary napkins from six countries: implications for women’s health.

Persistent Organic Pollutants: PCBs, Dioxin, OCPs, PAHs

Personal exposure to polycyclic aromatic hydrocarbons in Appalachian mining communities.

Organochlorine pollutants’ levels in hair, amniotic fluid and serum samples of pregnant women in Greece. A cohort study.

Perfluoroalkyl Substances

Perfluoroalkyl Substances in Drinking Water, Indoor Air and Dust from Ireland: Implications for Human Exposure.

Multiple pathways of human exposure to poly- and perfluoroalkyl substances (PFASs): From external exposure to human blood.

Flame Retardants

Multicenter biomonitoring of polybrominated diphenyl ethers (PBDEs) in colostrum from China: Body burden profile and risk assessment.

Pesticides

Mother/child organophosphate and pyrethroid distributions.

Arsenic/Metals

Determinants of arsenic methylation efficiency and urinary arsenic level in pregnant women in Bangladesh.

Assessment of residents’ total environmental exposure to heavy metals in China.

Variation in the Concentration of Metals in Road Dust Size Fractions Between 2 µm and 2 mm: Results from Three Metallurgical Centres in Poland.

Wildlife/Environment Studies

Phthalates

Phthalate esters in atmospheric PM2.5 and PM10 in the semi-arid city of Xi’an, Northwest China: Pollution characteristics, sources, health risks, and relationships with meteorological factors.

Parabens/Triclosan/Antimicrobials

Four typical personal care products in a municipal wastewater treatment plant in China: Occurrence, removal efficiency, mass loading and emission.

Environmental fate processes of antimicrobial peptides daptomycin, bacitracins, and polymyxins.

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

Comparing dioxin-like polychlorinated biphenyls in most consumed fish species of the Caspian Sea.

Polychlorinated naphthalenes, polychlorinated dibenzo-p-dioxins and dibenzofurans, and polychlorinated biphenyls in soils in an industrial park in Northwestern China: Levels, source apportionment, and potential human health risks.

Organochlorine Pesticides Residues in Blood of Peridomestic Populations of Virginia Opossum (Didelphis virginiana) from Ex-Henequen Rural Localities of Yucatan, Mexico.

Trace elements and persistent organic pollutants in chicks of 13 seabird species from Antarctica to the subtropics.

PAHs

Delayed effects of pyrene exposure during overwintering on the Arctic copepod Calanus hyperboreus.

Concentration level, distribution model, source analysis, and ecological risk assessment of polycyclic aromatic hydrocarbons in sediments from laizhou bay, China.

Perfluoroalkyl Substances

Release of side-chain fluorinated polymer-containing microplastic fibers from functional textiles during washing and first estimates of perfluoroalkyl acid emissions.

Levels, Patterns, and Biomagnification Potential of Perfluoroalkyl Substances in a Terrestrial Food Chain in a Nordic Skiing Area.

Occurrence of perfluoroalkyl substances in selected Victorian rivers and estuaries: An historical snapshot.

Perfluoroalkyl acids (PFAAs): Distribution, trends and aquatic ecological risk assessment in surface water from Tagus River basin (Spain).

Flame Retardants

Bioaccumulation and Trophic Transfer of Emerging Organophosphate Flame Retardants in the Marine Food Webs of Laizhou Bay, North China.

Organophosphate di- and tri-esters in indoor and outdoor dust from China and its implications for human exposure.

Pesticides

Intercity variability and local factors influencing the level of pesticide residues in marketed fruits and vegetables of China.

Brodifacoum Toxicity in American Kestrels (Falco sparverius) with Evidence of Increased Hazard Upon Subsequent Anticoagulant Rodenticide Exposure.

Dissipation of sixteen pesticide residues from various applications of commercial formulations on strawberry and their risk assessment under greenhouse conditions.

Sub-lethal effects of a neonicotinoid, clothianidin, on wild early life stage sockeye salmon (Oncorhynchus nerka).

Determination of 12 Carbamate Insecticides in Typical Vegetables and Fruits by Rapid Multi-Plug Filtration Cleanup and Ultra-Performance Liquid Chromatography/Tandem Mass Spectrometry Detection.

Movement of the neonicotinoid seed treatment clothianidin into groundwater, aquatic plants and insect herbivores.

Arsenic/Metals

Contamination of heavy metals and metalloids in biomass and waste fuels: Comparative characterisation and trend estimation.

Meta analysis of heavy metal pollution and sources in surface sediments of Lake Taihu, China.

Environmental risks associated with trace elements in sediments from Cartagena Bay, an industrialized site at the Caribbean.

Tungsten in Washington State surface waters.

Cadmium, mercury, and selenium in muscle of the scalloped hammerhead Sphyrna lewini from the tropical Eastern Pacific: Variation with age, molar ratios and human health risk.

Open mining pits and heaps of waste material as the source of undesirable substances: biomonitoring of air and soil pollution in former mining area (Dubnik, Slovakia).

Wintering in the Western Subarctic Pacific Increases Mercury Contamination of Red-Legged Kittiwakes.

Spatial patterns and temporal trends in mercury concentrations in common loons (Gavia immer) from 1998 to 2016 in New York’s Adirondack Park: has this top predator benefitted from mercury emission controls?

Arsenic in rice and rice products in Northwestern Mexico and health risk assessment.

Probabilistic risk assessment and spatial distribution of potentially toxic elements in groundwater sources in Southwestern Nigeria.

Mercury source changes and food web shifts alter contamination signatures of predatory fish from Lake Michigan.

Trace element analysis reveals bioaccumulation in the squid Gonatus fabricii from polar regions of the Atlantic Ocean.

Study of Cd Content Distribution and Its Bioaccessibility in Edible Tissues of Crab Portunus trituberculatus from the Coastal Area of Shandong, China.

Effects of cyanobacteria decomposition on the remobilization and ecological risk of heavy metals in Taihu Lake.

Identification of the sources and influencing factors of potentially toxic elements accumulation in the soil from a typical karst region in Guangxi, Southwest China.

Hydrogeochemical controls on arsenic contamination potential and health threat in an intensive agricultural area, northern China.

Potentially toxic elements (PTEs) in crops, soil, and water near Xiangtan manganese mine, China: potential risk to health in the foodchain.

High levels of fluoride contamination in groundwater of the semi-arid alluvial aquifers, Pakistan: evaluating the recharge sources and geochemical identification via stable isotopes and other major elemental data.

Geochemical evaluation of fluoride contamination in groundwater from Shanmuganadhi River basin, South India: implication on human health.

Heavy Metals in Sediment from the Urban and Rural Rivers in Harbin City, Northeast China.

Bioaccessibility of lead in Dittrichia viscosa plants and risk assessment of human exposure around a fertilizer industry in Lebanon.

Mercury contamination of the snow voles (Chionomys nivalis) in the West Carpathians.

Mercury concentrations in blubber and skin from stranded bottlenose dolphins (Tursiops truncatus) along the Florida and Louisiana coasts (Gulf of Mexico, USA) in relation to biological variables.

Modern modes of sediment distribution and the anthropogenic heavy metal pollution record in northeastern Beibu Gulf, south China sea.

Microplastics

Microplastic ingestion by zooplankton in Terengganu coastal waters, southern South China Sea.

Microplastic pollution in vegetable farmlands of suburb Wuhan, central China.

Microplastics in marine sediments and rabbitfish (Siganus fuscescens) from selected coastal areas of Negros Oriental, Philippines.

Observations and simulations of microplastic debris in a tide, wind, and freshwater-driven estuarine environment – the Delaware Bay.

Pharmaceuticals

Translocation of pharmaceuticals from wastewater into beehives.

Investigation of pharmaceuticals and their metabolites in Brazilian hospital wastewater by LC-QTOF MS screening combined with a preliminary exposure and in silico risk assessment.

Prioritization of pharmaceuticals in water environment in China based on environmental criteria and risk analysis of top-priority pharmaceuticals.

Mixtures

Cumulative risk analysis of carcinogenic contaminants in United States drinking water.

An interdisciplinary approach to assess human health risk in an urban environment: A case study in temperate Argentina.

Miscellaneous

Chronic toxicity of oil sands tailings pond sediments to early life stages of fathead minnow (Pimephales promelas).

An overview of paper and paper based food packaging materials: health safety and environmental concerns.

Predicted no-effect concentrations determination and ecological risk assessment for benzophenone-type UV filters in aquatic environment.

Risk Communication and Factors Influencing Private Well Testing Behavior: A Systematic Scoping Review.

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This list is not meant to be exhaustive, and generally does not include studies on detection, remediation, or treatment of EDCs. Note that journal publication dates may be different than dates added to PubMed. To see the searchable archives, please email me at Sarah@healthandenvironment.org and ask to join the group EDC_research@googlegroups.com. Archives are at https://groups.google.com/d/forum/edc_research. Compiled by Sarah Howard, Diabetes and Environment Program and HEEDS at Commonweal.

EHN EHN

Webinar: Fluoride, neurodevelopment, and cognition: a National Toxicology Program monograph
by Sarah Howard on November 19, 2024 at 5:00 pm
This Dec. 3 webinar features Dr. Kyla Taylor of NIEHS who will discuss the results of a National Toxicology Program monograph review that concluded there is "moderate confidence" in the scientific evidence that showed an association between higher levels of fluoride exposure and lower IQ in children.
Webinar: Behind the scenes at EPA: What's gone wrong and what does it mean for our work?
by Sarah Howard on November 19, 2024 at 3:56 pm
This Dec. 9 webinar, Behind the scenes at EPA: what's gone wrong and what does it mean for our work? is part 2 of a series on the future of EPA decision-making. Sponsored by the Collaborative for Health and Environment (CHE), Earthjustice, and UCSF's Earth Center.
Endocrine-disrupting chemicals: hazards and opportunities (ECHO) course
by Sarah Howard on October 31, 2024 at 2:50 pm
This course focuses on the chemical, biological, and societal challenges of endocrine-disrupting chemicals (EDCs) and new opportunities for moving forward. ECHO is a two-week intensive bootcamp-style career development course for graduate students, postdoctoral fellows, and professionals in the field. It is held at Woods Hole, Massachusetts.

EHN EHN

“We have enough evidence” to act on toxic plastic exposure now
by Katherine McMahon,Sarah Howard on November 22, 2024 at 3:31 pm
In a recent commentary published in The Lancet, Dr. Leonardo Trasande of NYU’s Grossman School of Medicine emphasizes the need to address the well-established health harms from exposure to chemical additives used in plastics. “Only through a serious and concerted effort to turn off the plastic tap will we apply the lessons learned from plastic use… and avoid the invisible chemicals used in plastic materials from becoming visible in the form of a larger global pandemic of chronic disease.”
Kids who adopt a gluten-free diet have increased arsenic levels
by Katherine McMahon,Sarah Howard on November 20, 2024 at 1:32 pm
A recent study published in The American Journal of Gastroenterology found that children who adopted a gluten-free (GF) diet after being diagnosed with celiac disease had significantly increased arsenic exposure after only six months. “More research needs to be done to determine whether there are long-term effects of this bump, but overall, I think it speaks to the importance of diversifying the grains in the gluten-free diet.”
NIEHS publishes new strategic plan
by Sarah Howard on November 19, 2024 at 6:03 pm
The National Institute of Environmental Health Sciences (NIEHS) published a 2025-2029 strategic plan, "Health at the Intersection of People and Their Environments."

EHN EHN

Trump’s second term could mean fewer protections for drinking water
by EHN Curators on November 21, 2024 at 12:30 pm
Donald Trump’s plans for the Environmental Protection Agency may include rolling back protections against PFAS and other drinking water threats, worrying public health advocates. Hiroko Tabuchi reports for The New York Times.
Kennedy’s fluoride policy faces obstacles
by EHN Curators on November 19, 2024 at 8:28 pm
President-elect Trump’s selection of Robert F. Kennedy Jr. to lead the Department of Health and Human Services won’t give him direct control over water fluoridation policies, though his influence could sway public and local debates. Miranda Willson reports for E&E News.
Scientists' Declaration for the Global Plastics Treaty
by Sarah Howard on November 19, 2024 at 5:54 pm
The signatories of this declaration are independent scientists with expertise on plastics, and who are free of conflicts of interest associated with the life cycle of plastics. Read it here and sign it here. Due Nov. 22, 2024.