New EDC articles, Oct. 16 – 22, 2019

Post author:HEEDS
Post published:October 22, 2019
Post category:EDC Science Weekly

A summary of articles on endocrine disrupting chemicals (EDCs) added to PubMed this week.

Contents: Regulations/Policy, Methods/Tools/Screening, Reviews, Human Health Studies, Laboratory Studies, Human Exposure Studies, Wildlife/Environment Studies.

Regulations/Policy

Shaping EU Plastic Policies: The Role of Public Health vs. Environmental Arguments.

Methods/Tools/Screening

Deciphering the Impact of Early-Life Exposures to Highly Variable Environmental Factors on Foetal and Child Health: Design of SEPAGES Couple-Child Cohort.

Development of the Texas A&M Superfund Research Program Computational Platform for Data Integration, Visualization, and Analysis.

Effect-directed analysis of progestogens and glucocorticoids at trace concentrations in river water.

Development of an estrogen-dependent breast cancer co-culture model as a tool for studying endocrine disruptors.

In vitro models of exosome biology and toxicology: New frontiers in biomedical research.

An Overview of Machine Learning and Big Data for Drug Toxicity Evaluation.

Reviews

Miscellaneous

Improving and Expanding Estimates of the Global Burden of Disease Due to Environmental Health Risk Factors.

Environment and obesity.

A review of maternal prenatal exposures to environmental chemicals and psychosocial stressors-implications for research on perinatal outcomes in the ECHO program.

In utero exposure to Persistent and Non-persistent Endocrine-disrupting chemicals and Anogenital Distance. A Systematic Review of Epidemiological Studies.

Is testicular germ cell cancer (TGCC) estrogen dependent? The role of endocrine disrupting chemicals (EDCs).

Effects of environmental stressors on stem cells.

A systematic review on hepatoprotective activity of quercetin against various drugs and toxic agents: Evidence from preclinical studies.

Environmental challenges for the nervous system and the brain in Japan.

BPA/Phenols

Evidence for Bisphenol B Endocrine Properties: Scientific and Regulatory Perspectives.

Phthalates

Assessing Human Exposure to Chemicals in Materials, Products and Articles: The International Risk Management Landscape for Phthalates.

Perfluoroalkyl Substances

Potential health effects of emerging environmental contaminants perfluoroalkyl compounds.

Flame Retardants

Phosphorus-Containing Flame Retardants from Biobased Chemicals and Their Application in Polyesters and Epoxy Resins.

Pesticides

The Herbicide Glyphosate and Its Apparently Controversial Effect on Human Health: An Updated Clinical Perspective.

The Neurophysiological Bases of the Impact of Neonicotinoid Pesticides on the Behaviour of Honeybees.

MicroRNAs as potential biomarkers of insecticide exposure: A Review.

[Impact of endocrine disrupting pesticides on breast cancer]. [in French]

Arsenic/Metals

Aluminum and vaccines: Current state of knowledge.

Mercury concentrations in biota in the Mediterranean Sea, a compilation of 40 years of surveys.

Air Pollution

Air pollution: the emergence of a major global health risk factor.

Air pollution is not ‘the new smoking’: comparing the disease burden of air pollution and smoking across the globe, 1990-2017.

Urban environment and psychiatric disorders: a review of the neuroscience and biology.

Fine particle environmental pollution and cardiovascular diseases.

Public health impact of coal-fired power plants: a critical systematic review of the epidemiological literature.

Ambient air pollution and diabetes: A systematic review and meta-analysis.

Developmental impact of air pollution on brain function.

Human Health Studies

BPA/Phenols/Parabens/Triclosan

Prenatal maternal and childhood bisphenol a exposure and brain structure and behavior of young children.

Prenatal phenol and paraben exposures in relation to child neurodevelopment including autism spectrum disorders in the MARBLES study.

Relationship between triclosan exposure and thyroid hormones: the Second Korean National Environmental Health Survey (2012-2014).

Phthalates

Mediation of the relationship between phthalate exposure and semen quality by oxidative stress among 1034 reproductive-aged Chinese men.

Associations of urinary phthalate metabolites with risk of papillary thyroid cancer.

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

Cardiovascular and cancer mortality in relation to dietary polychlorinated biphenyls and marine polyunsaturated fatty acids: a nutritional-toxicological aspect of fish consumption.

Flame Retardants

Thyroid function and decabromodiphenyl ethane (DBDPE) exposure in Chinese adults from a DBDPE manufacturing area.

Pesticides

Environmental Exposure to Pesticides and Breast Cancer in a Region of Intensive Agribusiness Activity in Brazil: A Case-Control Study.

Biomonitoring of Acetylcholinesterase (AChE) Activity among Smallholder Horticultural Farmers Occupationally Exposed to Mixtures of Pesticides in Tanzania.

Arsenic/Metals

Association between exposure to arsenic, nickel, cadmium, selenium, and zinc and fasting blood glucose levels.

Urinary 1H NMR metabolomics profile of Italian citizens exposed to background levels of arsenic. A (pre)cautionary tale.

Amyotrophic lateral sclerosis incidence following exposure to inorganic selenium in drinking water: A long-term follow-up.

Assessment of Endothelial Dysfunction with Methylated Arginines and L-arginine in Cadmium-Exposed People: a Pilot Study.

Implication of Physiological and Biochemical Variables of Prognostic Importance in Lead Exposed Subjects.

A cross-sectional study on school-age children living near a municipal waste incinerator: Urinary metal levels and renal impairment assessment.

Association between cadmium exposure and hearing impairment: a population-based study in Korean adults.

The effects of exposure to lead, cadmium and mercury on follicle-stimulating hormone levels in men and postmenopausal women: data from the Second Korean National Environmental Health Survey (2012-2014).

Does Information on Blood Heavy Metals Improve Cardiovascular Mortality Prediction? [yes it does]

Assessment of YAP gene polymorphisms and arsenic interaction in Mexican women with breast cancer.

Impact of arsenic exposure on clinicopathological characteristics of bladder cancer: A comparative study between patients from an arsenic-exposed region and nonexposed reference sites.

Metal and essential element levels in hair and association with autism severity.

Air Pollution

Prenatal exposure to air pollution as a potential risk factor for autism and ADHD.

Parental occupational exposure to diesel engine exhaust in relation to childhood leukaemia and central nervous system cancers: a register-based nested case-control study in Denmark 1968-2016.

Association of Exposure to Ambient Air Pollution With Thyroid Function During Pregnancy.

Ambient Particulate Matter Exposure and Under-Five and Maternal Deaths in Asia.

Associations of air pollution, obesity and cardiometabolic health in young adults: The Meta-AIR study.

Effects of prenatal exposure to air particulate matter on the risk of preterm birth and roles of maternal and cord blood LINE-1 methylation: A birth cohort study in Guangzhou, China.

High Education Level Protects European Americans but Not African Americans Against Chronic Obstructive Pulmonary Disease: National Health Interview Survey.

Mixtures

Maternal Exposure to Environmental Disruptors and Sexually-Dimorphic Changes in Maternal and Neonatal Oxidative Stress. [41 EDCs, including metals, phenols, and phthalates, individually and in mixtures]

Laboratory Studies

BPA/Phenols

An expanded toxicological profile of tetramethyl bisphenol F (TMBPF), a precursor for a new food-contact metal packaging coating.

High bisphenol A concentrations augment the invasiveness of tumor cells through Snail-1/Cx43/ERRγ-dependent epithelial-mesenchymal transition.

Effects of Phenolic Pollution on Interspecific Competition between Microcystis aeruginosa and Chlorella pyrenoidosa and their Photosynthetic Responses.

Phthalates

Benzyl butyl phthalate (BBP) triggers the malignancy of acute myeloid leukemia cells via upregulation of PDK4.

Triclosan

Triclosan stimulates human vascular endothelial cell injury via repression of the PI3K/Akt/mTOR axis.

Triclosan-induced liver and brain injury in zebrafish (Danio rerio) via abnormal expression of miR-125 regulated by PKCα/Nrf2/p53 signaling pathways.

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

Transgenerational impairment of ovarian induced by 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) associated with Igf2 and H19 in adult female rat.

Developmental exposure to PCB153 (2,2′,4,4′,5,5′-hexachlorobiphenyl) alters circadian rhythms and the expression of clock and metabolic genes.

Expression and significance of miR – 20b in retinal photoreceptor cells exposed to PCB1254.

Perfluoroalkyl Substances

PFOA evokes extracellular Ca2+ influx and compromises progesterone-induced response in human sperm.

Flame Retardants

Can PBDEs affect the pathophysiologic complex of epithelium in lung diseases?

Organotins

Tributyltin reduces bone mineral density by reprograming bone marrow mesenchymal stem cells in rat.

A proteomic study of Cunninghamella echinulata recovery during exposure to tributyltin.

Pesticides

Glyphosate Primes Mammary Cells for Tumorigenesis by Reprogramming the Epigenome in a TET3-Dependent Manner.

Pentachloronitrobenzene alters progesterone production and primordial follicle recruitment in cultured granulosa cells and rat ovary.

Behavioural and biochemical alterations by chlorpyrifos in aquatic insects: an emerging environmental concern for pristine Alpine habitats.

Mitigation of acetamiprid – induced renotoxicity by natural antioxidants via the regulation of ICAM, NF-kB and TLR 4 pathways.

Evaluation of apoptotic potential of glyphosate metabolites and impurities in human peripheral blood mononuclear cells (in vitro study).

Flumethrin at sublethal concentrations induces stresses in adult honey bees (Apis mellifera L.).

In vitro effects of glyphosate and Roundup on Sertoli cell physiology.

Growth and neurite stimulating effects of the neonicotinoid pesticide clothianidin on human neuroblastoma SH-SY5Y cells.

Effect of Herbicide Glyphosate on Drosophila melanogaster Fertility and Lifespan.

APOE genotype and postnatal chlorpyrifos exposure modulate gut microbiota and cerebral short-chain fatty acids in preweaning mice.

Chlorpyrifos and its metabolite modulates angiogenesis in the chorioallantoic membrane of chick embryo.

Exploring the multilevel hazards of thiamethoxam using Drosophila melanogaster.

Developmental toxicity and angiogenic defects of etoxazole exposed zebrafish (Danio rerio) larvae.

Lesion of the locus coeruleus damages learning and memory performance in paraquat and maneb-induced mouse Parkinson’s disease model.

A critical assessment of the genotoxicity profile of the fungicide tricyclazole.

Arsenic/Metals

Exposure to heavy metal-contaminated sediments disrupts gene expression, lipid profile, and life history traits in the midge Chironomus riparius.

Cadmium exposure affects growth performance, energy metabolism, and neuropeptide expression in Carassius auratus gibelio.

Biochemical responses revealed in an amphibian species after exposure to a forgotten contaminant: An integrated biomarker assessment. [vanadium]

MiR-122-5p and miR-326-3p: potential novel biomarkers for early detection of cadmium exposure.

The Effects of Gene-Environment Interactions Between Cadmium Exposure and Apolipoprotein E4 on Memory in a Mouse Model of Alzheimer’s Disease.

Evaluation of the sensitivity of Microhyla fissipes tadpoles to aqueous cadmium.

Protective effects of vitamin E on cadmium-induced apoptosis in rat testes.

Effect of both selenium and biosynthesized nanoselenium particles on cadmium-induced neurotoxicity in albino rats.

Microplastics

Microplastic-induced damage in early embryonal development of sea urchin Sphaerechinus granularis.

Microplastic particles reduce reproduction in the terrestrial worm Enchytraeus crypticus in a soil exposure.

Air Pollution

The Impact of Inhaled Ambient Ultrafine Particulate Matter on Developing Brain: Potential Importance of Elemental Contaminants.

Pharmaceuticals

Development of a generic physiologically based kinetic model to predict in vivo uterotrophic responses induced by estrogenic chemicals in rats based on in vitro bioassays. [DES, EE2, genistein, coumestrol, methoxychlor]

Mixtures

The interaction of mercury and methylmercury with chalcogenide nanoparticles.

Nanoparticles

Different factors determined the toxicokinetics of organic chemicals and nanomaterials exposure to zebrafish (Danio Rerio).

Human Exposure Studies

Phthalates

Urinary Concentrations of Diisoheptyl Phthalate Biomarkers in Convenience Samples of U.S. Adults in 2000 and 2018-2019.

Human exposure levels of PAEs in an e-waste recycling area: Get insight into impacts of spatial variation and manipulation mode.

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

Halogenated organic pollutant residuals in human bared and clothing-covered skin areas: Source differentiation and comprehensive health risk assessment. [flame retardants and PCBs]

Flame Retardants

Emerging and legacy brominated flame retardants in the breast milk of first time Irish mothers suggest positive response to restrictions on use of HBCDD and Penta- and Octa-BDE formulations.

Polybrominated diphenyl ethers in mothers’ breast milk and associated health risk to nursing infants in Uganda.

Arsenic/Metals

Population-based dietary exposure to mercury through fish consumption in the Southern Peruvian Amazon.

Mercury speciation in meconium and associated factors.

Trends of Blood Cadmium Concentration among Workers and Non-Workers in the United States (NHANES 2003-2012).

Toxic elements in packed red blood cells from smoker donors: a risk for paediatric transfusion?

Evaluation of antioxidant activities and essential/toxic metal levels and their health risk assessment in citrus fruits from Pakistan.

Collective exposure to lead from an approved natural product-derived drug in Korea.

Human exposure and risk associated with trace element concentrations in indoor dust from Australian homes.

Air Pollution

Household Smoking Status and Heavy Metal Concentrations in Toenails of Children.

EDCs in Diet

Diet as a Source of Exposure to Environmental Contaminants for Pregnant Women and Children from Six European Countries. [OCPs, PBDEs, PCBs, PFAS, heavy metals, phthalates, phenols, and pesticides.]

The impact of dietary habits on contaminant exposures. [POPs, metals, etc. “The individuals having a diet more in compliance with the dietary guidelines have a higher exposure to contaminants than individuals having a diet less in compliance…”]

Wildlife/Environment Studies

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

Population recovery of peregrine falcons in central Norway in the 4 decades since the DDT-ban.

Passive Sampling of Persistent Organic Pollutants in Four Coastal Aquatic Systems of Puerto Rico: A Pilot Study.

The health concern of polychlorinated biphenyls (PCBs) in a notorious e-waste recycling site.

Perfluoroalkyl Substances

Occurrence and source apportionment of novel and legacy poly/perfluoroalkyl substances in Hai River basin in China using receptor models and isomeric fingerprints.

Flame Retardants

Halogenated flame retardants in sediments from the Upper Laurentian Great Lakes: Implications to long-range transport and evidence of long-term transformation.

Pesticides

Effects of Agricultural Pesticides in Aquafeeds on Wild Fish Feeding on Leftover Pellets Near Fish Farms.

Environmental risk assessment of triazine herbicides in the Bohai Sea and the Yellow Sea and their toxicity to phytoplankton at environmental concentrations.

Nutrients and sediment modify the impacts of a neonicotinoid insecticide on freshwater community structure and ecosystem functioning.

Seasonal Toxicity Observed with Amphipods (Eohaustorius estuarius) at Paleta Creek, San Diego Bay, USA.

Evaluation of Pesticides Found in Oregon Cannabis from 2016 to 2017.

Botanical Origin of Pesticide Residues in Pollen Loads Collected by Honeybees During and After Apple Bloom.

Arsenic/Metals

Appraisal of metallic pollution and ecological risks in agricultural soils of Alborz province, Iran, employing contamination indices and multivariate statistical analyses.

Mercury isotope variations within the marine food web of Chinese Bohai Sea: Implications for mercury sources and biogeochemical cycling.

Occurrence, speciation and fate of mercury in the sewage sludge of China.

Using Mosses as Bioindicators of Potentially Toxic Element Contamination in Ecologically Valuable Areas Located in the Vicinity of a Road: A Case Study.

Forms of mercury in the Baltic mussel (Mytilus trossulus): Human and ecosystem health risk assessment.

Bioaccumulation of heavy metals in some commercially important fishes from a tropical river estuary suggests higher potential health risk in children than adults.

Trace Element Concentrations in Livers of Pacific Harbor Seals (Phoca vitulina richardii) from San Juan County, Washington, USA.

Accumulating Mercury and Methylmercury Burdens in Watersheds Impacted by Oil Sands Pollution.

Variation in Hg accumulation between demersal and pelagic fish from Puruzinho Lake, Brazilian Amazon.

Assessment of heavy metals in benthic macroinvertebrates, water and sediments in River Isiukhu, Kenya.

Heavy Metal, Arsenic and Selenium Concentrations in Bird Feathers from a Region in Southern China Impacted by Intensive Mining of Non-ferrous Metals.

Microplastics

Vertical Distribution of Microplastics in the Water Column and Surficial Sediment from the Milwaukee River Basin to Lake Michigan.

Abundance, distribution patterns, and identification of microplastics in Brisbane River sediments, Australia.

Assessment of microplastic pollution: occurrence and characterisation in Vesijärvi lake and Pikku Vesijärvi pond, Finland.

Variation in microplastics composition at small spatial and temporal scales in a tidal flat of the Yangtze Estuary, China.

Functional response quantifies microplastic uptake by a widespread African fish species.

Mediterranean dirty edge: High level of meso and macroplastics pollution on the Turkish coast.

First evidence of microplastics ingestion in benthic amphipods from Svalbard.

Air Pollution

Source Identification and Health Risk Assessment of Polycyclic Aromatic Hydrocarbon-Enriched PM2.5 in Tangshan, China.

Pharmaceuticals

Micropollutants in Lake Como water in the context of circular economy: A snapshot of water cycle contamination in a changing pollution scenario.

Mixtures

Warming and pollutants interact to modulate octocoral immunity and shape disease outcomes. [copper and temperature]

Effects of industrial pollution on the reproductive biology of Squalius laietanus (Actinopterygii, Cyprinidae) in a Mediterranean stream (NE Iberian Peninsula). [a WWTP]

Miscellaneous

Simultaneous determination of drug active compound, hormones, pesticides, and endocrine disruptor compounds in wastewater samples by GC-MS with direct calibration and matrix matching strategies after preconcentration with dispersive liquid-liquid microextraction.

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This list is not meant to be exhaustive, and generally does not include studies on detection, remediation, or treatment of EDCs. Note that journal publication dates may be different than dates added to PubMed. To see the searchable archives, please email me at Sarah@healthandenvironment.org and ask to join the group EDC_research@googlegroups.com. Archives are at https://groups.google.com/d/forum/edc_research. Compiled by Sarah Howard, Diabetes and Environment Program and HEEDS at Commonweal.

EHN EHN

Webinar: Fluoride, neurodevelopment, and cognition: a National Toxicology Program monograph
by Sarah Howard on November 19, 2024 at 5:00 pm
This Dec. 3 webinar features Dr. Kyla Taylor of NIEHS who will discuss the results of a National Toxicology Program monograph review that concluded there is "moderate confidence" in the scientific evidence that showed an association between higher levels of fluoride exposure and lower IQ in children.
Webinar: Behind the scenes at EPA: What's gone wrong and what does it mean for our work?
by Sarah Howard on November 19, 2024 at 3:56 pm
This Dec. 9 webinar, Behind the scenes at EPA: what's gone wrong and what does it mean for our work? is part 2 of a series on the future of EPA decision-making. Sponsored by the Collaborative for Health and Environment (CHE), Earthjustice, and UCSF's Earth Center.
Endocrine-disrupting chemicals: hazards and opportunities (ECHO) course
by Sarah Howard on October 31, 2024 at 2:50 pm
This course focuses on the chemical, biological, and societal challenges of endocrine-disrupting chemicals (EDCs) and new opportunities for moving forward. ECHO is a two-week intensive bootcamp-style career development course for graduate students, postdoctoral fellows, and professionals in the field. It is held at Woods Hole, Massachusetts.

EHN EHN

“We have enough evidence” to act on toxic plastic exposure now
by Katherine McMahon,Sarah Howard on November 22, 2024 at 3:31 pm
In a recent commentary published in The Lancet, Dr. Leonardo Trasande of NYU’s Grossman School of Medicine emphasizes the need to address the well-established health harms from exposure to chemical additives used in plastics. “Only through a serious and concerted effort to turn off the plastic tap will we apply the lessons learned from plastic use… and avoid the invisible chemicals used in plastic materials from becoming visible in the form of a larger global pandemic of chronic disease.”
Kids who adopt a gluten-free diet have increased arsenic levels
by Katherine McMahon,Sarah Howard on November 20, 2024 at 1:32 pm
A recent study published in The American Journal of Gastroenterology found that children who adopted a gluten-free (GF) diet after being diagnosed with celiac disease had significantly increased arsenic exposure after only six months. “More research needs to be done to determine whether there are long-term effects of this bump, but overall, I think it speaks to the importance of diversifying the grains in the gluten-free diet.”
NIEHS publishes new strategic plan
by Sarah Howard on November 19, 2024 at 6:03 pm
The National Institute of Environmental Health Sciences (NIEHS) published a 2025-2029 strategic plan, "Health at the Intersection of People and Their Environments."

EHN EHN

Trump’s second term could mean fewer protections for drinking water
by EHN Curators on November 21, 2024 at 12:30 pm
Donald Trump’s plans for the Environmental Protection Agency may include rolling back protections against PFAS and other drinking water threats, worrying public health advocates. Hiroko Tabuchi reports for The New York Times.
Kennedy’s fluoride policy faces obstacles
by EHN Curators on November 19, 2024 at 8:28 pm
President-elect Trump’s selection of Robert F. Kennedy Jr. to lead the Department of Health and Human Services won’t give him direct control over water fluoridation policies, though his influence could sway public and local debates. Miranda Willson reports for E&E News.
Scientists' Declaration for the Global Plastics Treaty
by Sarah Howard on November 19, 2024 at 5:54 pm
The signatories of this declaration are independent scientists with expertise on plastics, and who are free of conflicts of interest associated with the life cycle of plastics. Read it here and sign it here. Due Nov. 22, 2024.