New EDC articles, week of Sep. 25 – Oct. 1, 2019

A summary of articles on endocrine disrupting chemicals (EDCs) added to PubMed this week.

Contents: Interesting Research of the Week, Tools/Screening, Reviews, Human Health Studies, Laboratory Studies, and Wildlife/Environment/Exposure Studies.

Interesting Research of the Week

Associations between sociodemographic characteristics and exposures to PBDEs, OH-PBDEs, PCBs, and PFASs in a diverse, overweight population of pregnant women.

Patterns and Variability of Endocrine-disrupting Chemicals During Pregnancy: Implications for Understanding the Exposome of Normal Pregnancy.

Tools/Screening

Generating the Blood Exposome Database Using a Comprehensive Text Mining and Database Fusion Approach. [about the blood exposome database, available online here]

Limited Chemical Structural Diversity Found to Modulate Thyroid Hormone Receptor in the Tox21 Chemical Library.

Miscellaneous

Global Perspective on Careers in Environmental Toxicologic Pathology: The 2019 Society of Toxicologic Pathology Annual Symposium Lunchtime Career Development Session.

Reviews

Before the beginning: environmental exposures and reproductive and obstetrical outcomes.

The influence of polyphenols on metabolic disorders caused by compounds released from plastics – Review.

Children’s environmental health based on birth cohort studies of Asia (2) – air pollution, pesticides, and heavy metals.

Effects of Phytoestrogens on the Developing Brain, Gut Microbiota, and Risk for Neurobehavioral Disorders.

Environmental Factors Associated With Type 1 Diabetes. [no discussion of EDCs aside for a quick mention of air pollution]

Mechanisms of pollutant-induced toxicity in skin and detoxification: Anti-pollution strategies and perspectives for cosmetic products.

Ecological interactions in asthma: from environment to microbiota and immune responses.

Primary prevention as an essential factor ensuring sustainability of health systems: the example of congenital anomalies.

BPA

Early Steps of Mammary Stem Cell Transformation by Exogenous Signals; Effects of Bisphenol Endocrine Disrupting Chemicals and Bone Morphogenetic Proteins.

Persistent Organic Pollutants

Concentrations of PCDD/Fs in Human Blood: A Review of Data from the Current Decade.

Aryl Hydrocarbon Receptor Modulates Carcinogenesis and Maintenance of Skin Cancers.

Pesticides

Microbiota and organophosphates.

Health, environment and colonial legacies: Situating the science of pesticides, bananas and bodies in Ecuador.

A comprehensive review on enzymatic degradation of the organophosphate pesticide malathion in the environment.

Metals

Exposure to Inorganic Arsenic and Lead and Autism Spectrum Disorder in Children: A Systematic Review and Meta-Analysis.

Mercury exposure, epigenetic alterations, and brain tumorigenesis: A possible relationship?

Air Pollution

Air pollution and placental mitochondrial DNA copy number: Mechanistic insights and epidemiological challenges.

Human Health Studies

BPA/Phenols

Urinary bisphenol A and serum lipids: a meta-analysis of six NHANES examination cycles (2003-2014). also see associated commentary in JECH, Towards a more reliable assessment of health risks associated with the population exposure to bisphenols.

Urinary bisphenol A and thyroid function by BMI in the Korean National Environmental Health Survey (KoNEHS) 2012-2014.

Persistent Organic Pollutants

Serum levels of polychlorinated biphenyls and risk of non-Hodgkin lymphoma: A hospital-based case-control study.

Exposure to Persistent Organic Pollutants and Birth Characteristics: The Upstate KIDS Study.

Perfluoroalkyl Substances

Perfluoroalkyl substances and bone health in young men: a pilot study.

Pesticides

Environmental exposures in young adults with declining kidney function in a population at risk of Mesoamerican nephropathy. [pesticides and metals]

Association Between Occupational Exposure to Pesticides and Cardiovascular Disease Incidence: The Kuakini Honolulu Heart Program.

Arsenic/Metals

Maternal urinary cadmium, glucose intolerance and gestational diabetes in the New Hampshire Birth Cohort Study.

Serum levels of lead and selenium in patients with premature graying of the hair.

Air Pollution

Sex-specific associations of autism spectrum disorder with residential air pollution exposure in a large Southern California pregnancy cohort.

Public Transport Strikes and Their Relationship With Air Pollution, Mortality and Hospital Admissions.

Relationship between atmospheric pollutants and risk of death caused by cardiovascular and respiratory diseases and malignant tumors in Shenyang, China, from 2013 to 2016: an ecological research.

Short-term effects of ambient particulate matter on blood pressure among children and adolescents:A cross-sectional study in a city of Yangtze River delta, China.

Pediatric Psychiatric Emergency Department Utilization and Fine Particulate Matter: A Case-Crossover Study.

Critical windows for maternal fine particulate matter exposure and adverse birth outcomes: The Shanghai birth cohort study.

Air Pollution and Preterm Birth: Do Air Pollution Changes over Time Influence Risk in Consecutive Pregnancies among Low-Risk Women?

Miscellaneous

A Comparison of Prenatal Exposures in Children with and without a Diagnosis of Autism Spectrum Disorder. [air pollution, some pharmaceuticals, vitamins, etc but not most EDCs]

Laboratory Studies

BPA/Phenols

Effect of developmental exposure to bisphenol A on steroid hormone and vitamin D3 metabolism. [we need more research on EDCs and vitamin D!]

BPA Alters Estrogen Receptor Expression in the Heart After Viral Infection Activating Cardiac Mast Cells and T Cells Leading to Perimyocarditis and Fibrosis.

Bisphenols disrupt differentiation of the pigmented cells during larval brain formation in the ascidian.

Toxicity and multigenerational effects of bisphenol S exposure to Caenorhabditis elegans on developmental, biochemical, reproductive and oxidative stress.

Chronic effects of bisphenol S and bisphenol SIP on freshwater waterflea and ecological risk assessment.

Bisphenol A disturbs transcription of steroidogenic genes in ovary of rare minnow Gobiocypris rarus via the abnormal DNA and histone methylation.

Inhibitory effect of octyl-phenol and bisphenol A on calcium signaling in cardiomyocyte differentiation of mouse embryonic stem cells.

Non-alcoholic Fatty Liver Disease Induced by Perinatal Exposure to Bisphenol a Is Associated With Activated mTOR and TLR4/NF-κB Signaling Pathways in Offspring Rats.

Phthalates

Effects of Di(2-ethylhexyl)phthalate on Bone Metabolism in Ovariectomized Mice.

Di-n-butyl phthalate induced autophagy of uroepithelial cells via inhibition of hedgehog signaling in newborn male hypospadias rats.

Persistent Organic Pollutants

The Ancestral Environment Shapes Antiviral CD8+ T cell Responses across Generations. [TCDD]

Prenatal Exposure to Environmentally-Relevant Contaminants Perturbs Male Reproductive Parameters Across Multiple Generations that are Partially Protected by Folic Acid Supplementation.

Dioxin-like (DL-) polychlorinated biphenyls induced immunotoxicity through apoptosis in mice splenocytes via the AhR mediated mitochondria dependent signaling pathways.

Characterization of the aryl hydrocarbon receptor (AhR) pathway in Anabas testudineus and mechanistic exploration of the reduced sensitivity of AhR2a.

In silico toxicity evaluation of dioxins using structure-activity relationship (SAR) and two-dimensional quantitative structure-activity relationship (2D-QSAR).

Perfluoroalkyl Substances

An in vitro and in silico investigation of human pregnane X receptor agonistic activity of poly- and perfluorinated compounds using the heuristic method-best subset and comparative similarity indices analysis.

Perfluorodecanoic acid-induced oxidative stress and DNA damage investigated at the cellular and molecular levels.

Metabolomic profiles associated with exposure to per- and polyfluoroalkyl substances (PFASs) in aquatic environments.

Flame Retardants

PBDEs Concentrate in the Fetal Portion of the Placenta: Implications for Thyroid Hormone Dysregulation.

Comet assay in neural cells as a tool to monitor DNA damage induced by chemical or physical factors relevant to environmental and occupational exposure.

The enrichment and purification of hexabromocyclododecanes and its effects on thyroid in zebrafish.

Organophosphorus flame retardant (tricresyl phosphate) trigger apoptosis in HepG2 cells: Transcriptomic evidence on activation of human cancer pathways.

Pesticides

Dysregulation of endocrine disruption, apoptosis and the transgenerational toxicity induced by spirotetramat.

Toxic effects of flufenoxuron on development and vascular formation during zebrafish embryogenesis.

10,000-Times Diluted Doses of ACCase-Inhibiting Herbicides Can Permanently Change the Metabolomic Fingerprint of Susceptible Avena fatua L. Plants.

Behavioral effects in adult zebrafish after developmental exposure to carbaryl.

Chronic thiamethoxam exposure impairs the HPG and HPT axes in adult Chinese rare minnow (Gobiocypris rarus): Docking study, hormone levels, histology, and transcriptional responses.

Atrazine-induced toxicity in goat spermatozoa is alleviated to some extent by polyphenol-enriched feed.

Acute uterine effects and long-term reproductive alterations in postnatally exposed female rats to a mixture of commercial formulations of endosulfan and glyphosate.

Exposure of Larval Zebrafish to the Insecticide Propoxur Induced Developmental Delays that Correlate with Behavioral Abnormalities and Altered Expression of hspb9 and hspb11.

Arsenic/Metals

Arsenic is more potent than cadmium or manganese in disrupting the INS-1 beta cell microRNA landscape.

Mercury affects uterine myogenic activity even without producing any apparent toxicity in rats: Involvement of calcium-signaling cascades.

Dietary Lead and Phosphate Interactions Affect Oral Bioavailability of Soil Lead in the Mouse.

Continuous Developmental and Early Life Trichloroethylene Exposure Promoted DNA Methylation Alterations in Polycomb Protein Binding Sites in Effector/Memory CD4+ T Cells.

Maternal selenium deficiency during pregnancy in mice increases thyroid hormone concentrations, alters placental function and reduces fetal growth.

Transcriptome analysis of genes expressed in the earthworm Eisenia fetida in response to cadmium exposure.

Organotins

Parental exposure to triphenyltin inhibits growth and disrupts thyroid function in zebrafish larvae.

Microplastics

Interactive effects of warming and microplastics on metabolism but not feeding rates of a key freshwater detritivore.

Air Pollution

Cardiovascular effects of diesel exhaust inhalation: photochemically altered versus freshly emitted in mice.

17ß-estradiol affects lung function and inflammation following ozone exposure in a sex-specific manner.

Miscellaneous

Toxic effects of triptolide on adrenal steroidogenesis in H295R cells and female rats.

Naturally occurring mixtures of Alternaria toxins: anti-estrogenic and genotoxic effects in vitro.

Imbalance in the Blood Concentrations of Selected Steroids in Pre-pubertal Gilts Depending on the Time of Exposure to Low Doses of Zearalenone.

Do mineral and corn oil serve as potential endocrine disruptors in the gerbil prostate?

Tri-ortho-cresyl phosphate (TOCP)-induced reproductive toxicity involved in placental apoptosis, autophagy and oxidative stress in pregnant mice. [TOCP is a plasticizer]

Exposure to graphene oxide at environmental concentrations induces thyroid endocrine disruption and lipid metabolic disturbance in Xenopus laevis.

Additives migrating from 3D-printed plastic induce developmental toxicity and neuro-behavioural alterations in early life zebrafish (Danio rerio).

Wildlife/Environment/Exposure Studies

Parabens/Triclosan/Antimicrobials

Parabens in breast milk and possible sources of exposure among lactating women in Korea.

Biomonitoring of parabens in human milk and estimated daily intake for breastfed infants.

Persistent Organic Pollutants

Maternal Transfer of Persistent Organic Pollutants to Sea Turtle Eggs: A Meta-Analysis Addressing Knowledge and Data Gaps Towards an Improved Synthesis of Research Outputs.

Contamination and genotoxicity biomarker responses in bivalve mussels from the major Lithuanian rivers.

Assessment of polychlorinated biphenyls (PCBs) in the Himalayan Riverine Network of Azad Jammu and Kashmir.

Persistent organic pollutants in killer whales (Orcinus orca) of the Russian Far East.

Perfluoroalkyl Substances

Ecological risk assessment for perfluorooctanoic acid in soil using a species sensitivity approach.

Concentration, distribution and sources of perfluoroalkyl substances and organochlorine pesticides in surface sediments of the northern Bering Sea, Chukchi Sea and adjacent Arctic Ocean.

Assessment of perfluoroalkyl substances levels in tap and bottled water samples from Turkey.

Ecological risk assessment for perfluorooctanoic acid in soil using a species sensitivity approach.

Poly- and per-fluoroalkyl compounds in sediments of the Laurentian Great Lakes: Loadings, temporal trends, and sources determined by positive matrix factorization

Poly- and Perfluoroalkyl Substances (PFAS) in Seawater and Plankton from the Northwestern Atlantic Margin.

Point source characterization of per- and polyfluoroalkyl substances (PFASs) and extractable organofluorine (EOF) in freshwater and aquatic invertebrates.

Children’s exposure to perfluoroalkyl acids – a modelling approach.

Flame Retardants

Organophosphorus flame retardants in a typical freshwater food web: Bioaccumulation factors, tissue distribution, and trophic transfer.

Determination of newly synthesized dihydroxylated polybrominated diphenyl ethers in sea fish by gas chromatography-tandem mass spectrometry.

New insights into the anaerobic microbial degradation of decabrominated diphenyl ether (BDE-209) in coastal marine sediments.

Pesticides

Mechanisms behind interactive effects of temperature and bifenthrin on the predator avoidance behaviors in parr of chinook salmon (Oncorhynchus tshawytscha).

A survey of the secondary exposure to organophosphate and organochlorine pesticides and the impact of preventive factors in female villagers.

Physiologically based pharmacokinetic modeling of salivary concentrations for non-invasive biomonitoring of 2,4-dichlorophenoxyacetic acid (2,4-D).

Arsenic/Metals

Distribution, ecological risk assessment and source identification of heavy metals in surface sediments of Huixian karst wetland, China.

Food safety risk assessment of metal pollution in crayfish from two historical mining areas: Accounting for bioavailability and cooking extractability.

Soil contamination in China: Current priorities, defining background levels and standards for heavy metals.

Evaluation of blood mercury and serum selenium levels in the pregnant population of the Community of Madrid, Spain.

Soil organic matter prevails over heavy metal pollution and vegetation as a factor shaping soil microbial communities at historical Zn-Pb mining sites.

A complex urban ecological investigation in a mid-sized Hungarian city – SITE assessment and monitoring of a liveable urban area, PART 1: Water quality measurement.

Bioaccessibility and human health risk assessment of metal(loid)s in soil from an e-waste open burning site in Agbogbloshie, Accra, Ghana.

Risk for Indo-Pacific humpback dolphins (Sousa chinensis) and human health related to the heavy metal levels in fish from the Pearl River Estuary, China.

Mercury and methylmercury levels in soils associated with coal-fired power plants in central-northern Chile.

Microplastics

Microplastics in the wastewater treatment plants (WWTPs): Occurrence and removal.

Miscellaneous

Perchlorate in human milk samples from the maternal-infant research on environmental chemicals study (MIREC).

Patterns of estrogenic activity in the Baltic Sea.

Public awareness level and occurrence of pharmaceutical residues in drinking water with potential health risk: A study from Kajang (Malaysia).

Lifelong exposure to multiple stressors through different environmental pathways for European populations. [electromagnetic fields, ultraviolet light, phthalates, and metals]

A characterization of personal care product use among undergraduate female college students in South Carolina, USA.

This list is not meant to be exhaustive, and generally does not include studies on detection, remediation, or treatment of EDCs. Note that journal publication dates may be different than dates added to PubMed.

To see the searchable archives, please email me at Sarah@healthandenvironment.org and ask to join the group EDC_research@googlegroups.com. Archives are at https://groups.google.com/d/forum/edc_research. Compiled by Sarah Howard, Diabetes and Environment Program and HEEDS at Commonweal.