New EDC articles, week of Aug. 7 – 13, 2019

Post author:HEEDS
Post published:August 13, 2019
Post category:EDC Science Weekly

A summary of articles on endocrine disrupting chemicals (EDCs) added to PubMed this week.

Contents: Interesting Research of the Week, Regulations/Policy/Screening, Reviews, Human Health Studies, Laboratory Studies, and Wildlife/Environment/Exposure Studies.

Interesting Research of the Week

A few studies on neonicotinoids and honey bees have made the news:

Neonicotinoids in excretion product of phloem-feeding insects kill beneficial insects.
An assessment of acute insecticide toxicity loading (AITL) of chemical pesticides used on agricultural land in the United States.

and this is a new topic:

Hexachlorocyclohexane exposure alters the microbiome of colostrum in Chinese breastfeeding mothers.

Regulations/Policy/Screening

Body-decorating products: Ingredients of permanent and temporary tattoos from analytical and European regulatory perspectives.

Brazil unwisely gives pesticides a free pass. [letter in Science]

Screening

Characterization of Estrogenic and Androgenic Activities for Bisphenol A-like Chemicals (BPs): In Vitro Estrogen and Androgen Receptors Transcriptional Activation, Gene Regulation, and Binding Profiles.

The use of evidence from high-throughput screening and transcriptomic data in human health risk assessments.

A Convenient Plant-Based Detection System to Monitor Androgenic Compound in the Environment.

Reviews

Special Issue

The August issue of the journal Current Opinion in Endocrine and Metabolic Research is focused on EDCs. It includes these articles; all are reviews:

Additional Reviews

The Role of Environmental Disruptor Chemicals in the Development of Non Communicable Disease.

Endocrine disrupters and possible contribution to pubertal changes.

How to Obtain a Reliable Estimate of Occupational Exposure? Review and Discussion of Models’ Reliability.

Differences between male and female prostates in terms of physiology, sensitivity to chemicals and pathogenesis – A review in a rodent model.

Generalized additive models: Building evidence of air pollution, climate change and human health.

Persistent Organic Pollutants

Mitochondrial Involvement in the Adaptive Response to Chronic Exposure to Environmental Pollutants and High-Fat Feeding in a Rat Liver and Testis. [DDE]

Adverse effects of hexaclorobenzene exposure in children and adolescents.

Arsenic/Metals

Low-Level Exposure to Arsenic in Drinking Water and Risk of Lung and Bladder Cancer: A Systematic Review and Dose-Response Meta-Analysis.

Micronucleus assay for monitoring the genotoxic effects of arsenic in human populations: A systematic review of the literature and meta-analysis.

Maternal Exposure to Cadmium and Fetal Growth: a Systematic Review and Meta-Analysis.

Additional Chemicals

Environmental Exposure to Crude Oil: A Potential Risk for Chronic Kidney Disease (CKD) in Disadvantaged Countries.

Pharmaceutically active compounds in aqueous environment: A status, toxicity and insights of remediation.

Environmental persistence, hazard, and mitigation challenges of nitroaromatic compounds.

The Toxicity of Nanoparticles to Organisms in Freshwater.

Strength of methods assessment for aquatic primary producer toxicity data; a critical review of atrazine studies from the peer-reviewed literature

Human Health Studies

BPA/Phenols

Urinary bisphenol analogues concentrations and biomarkers of oxidative DNA and RNA damage in Chinese school children in East China: A repeated measures study.

Phthalates

Phthalate Ester Contamination in Intensively Managed Greenhouse Facilities and the Assessment of Carcinogenic and Non-Carcinogenic Risk: A Regional Study.

Phthalate exposure from drugs during pregnancy and possible risk of preterm birth and small for gestational age.

Persistent Organic Pollutants

Exposure to Polybrominated Diphenyl Ethers and a Polybrominated Biphenyl and Risk of Thyroid Cancer in Women: Single and Multi-Pollutant Approaches.

An Altered DNA Methylation Status in the Human Umbilical Cord Is Correlated with Maternal Exposure to Polychlorinated Biphenyls.

Perfluoroalkyl Substances

Concentration of selected liver enzymes across the stages of glomerular function: the associations with PFOA and PFOS.

Association between prenatal exposure to perfluoroalkyl substances and asthma-related diseases in preschool children.

Pesticides

[Evaluation of the effect of pesticide use on the health of rural workers in irrigated fruit farming]. [in Portuguese]

Arsenic/Metals

Toxic metals in cord blood and later development of Type 1 diabetes.

Adaptation to extreme environments in an admixed human population from the Atacama Desert. [arsenic]

The association between cadmium exposure and chronic airflow limitation and emphysema: The Swedish CArdioPulmonary BioImage Study (SCAPIS Pilot).

Association of blood chromium and rare earth elements with the risk of DNA damage in chromate exposed population.

Mixtures

Seminal plasma metabolites mediate the associations of multiple environmental pollutants with semen quality in Chinese men. [arsenic, phthalates, PFASs]

Air Pollution

Exposure to the use of firewood for cooking in Brazil and its relation with the health problems of the population.

Endotoxin and particulate matter emitted by livestock farms and respiratory health effects in neighboring residents.

Air pollution, particulate matter composition and methylation-based biologic age.

Exposure to ambient air pollution and the incidence of congestive heart failure and acute myocardial infarction: A population-based study of 5.1 million Canadian adults living in Ontario.

Associations Between Ambient Air Pollutant Concentrations and Birth Weight: A Quantile Regression Analysis.

Fine Particulate Air Pollution and Birthweight: Differences in Associations Along the Birthweight Distribution.

Air pollution exposure and risk of spontaneous abortion in the Nurses’ Health Study II.

Associations of ambient PM2.5 and O3 with cardiovascular mortality: a time-series study in Hefei, China.

Associations of Combined Exposures to Surrounding Green, Air Pollution, and Road Traffic Noise with Cardiometabolic Diseases.

Prenatal and Childhood Traffic-Related Air Pollution Exposure and Telomere Length in European Children: The HELIX Project.

Exposure-Response Associations of Household Air Pollution and Buccal Cell Telomere Length in Women Using Biomass Stoves.

Health effects of particulate matter in major Indian cities.

Ambient air pollution exposure and risk and progression of interstitial lung abnormalities: the Framingham Heart Study.

Outdoor Air Pollution and the Burden of Childhood Asthma across Europe.

Industrial air pollution and mortality in the Taranto area, Southern Italy: A difference-in-differences approach.

Association between prenatal exposure to household inhalants exposure and ADHD-like behaviors at around 3 years of age: Findings from Shenzhen Longhua Child Cohort Study.

Long-term exposure to ambient fine particulate pollution, sleep disturbance and their interaction effects on suicide attempts among Chinese adolescents.

Effect of air pollutant emission reduction policies on hospital visits for asthma in Seoul, Korea; Quasi-experimental study.

Particulate matter-attributable mortality and relationships with carbon dioxide in 250 urban areas worldwide.

Long-term exposure to air pollution and hospitalization for dementia in the Rome longitudinal study.

Ambient fine particulate matter is associated with increased emergency ambulance dispatches for psychiatric emergencies.

Miscellaneous

Lavender products associated with premature thelarche and prepubertal gynecomastia: Case reports and EDC activities.

Maternal Exposure to Housing Renovation During Pregnancy and Risk of Offspring with Congenital Malformation: The Japan Environment and Children’s Study.

Paternal bias: the impact of not accounting for paternal confounders in reproductive epidemiological studies.

Laboratory Studies

BPA/Phenols

Bisphenol A increases intestinal permeability through disrupting intestinal barrier function in mice.

Maternal exposure to environmentally relevant doses of bisphenol A causes reproductive dysfunction in F1 adult male rats: protective role of melatonin.

Bisphenol A induces apoptosis, oxidative stress and inflammatory response in colon and liver of mice in a mitochondria-dependent manner.

Effects of Bisphenol A on redox balance in red blood and sperm cells and spermatic quality in zebrafish Danio rerio.

Biochemical responses of freshwater mussel Unio tumidus to titanium oxide nanoparticles, Bisphenol A, and their combination.

Effects of environmental chemicals on the proliferation and differentiation of neural stem cells. [BPA, paraquat, mercury]

Phthalates

Role of JNK and ERK1/2 MAPK signaling pathway in testicular injury of rats induced by di-N-butyl-phthalate (DBP).

Di-n-butyl phthalate, butylbenzyl phthalate, and their metabolites exhibit different apoptotic potential in human peripheral blood mononuclear cells.

Persistent Organic Pollutants

Effects of 2,3′,4,4’5-pentachlorobiphenyl exposure during pregnancy on epigenetic imprinting and maturation of offspring’s oocytes in mice.

A Comparative Study of Three Alternative Avian Toxicity Testing Methods: Effects on Hepatic Gene Expression in the Chicken Embryo. [TCDD]

2,3,7,8-Tetrachlorodibenzo-p-dioxin modifies alternative splicing in mouse liver.

2,3,7,8-Tetrachlorodibenzo-p-dioxin-induced aryl hydrocarbon receptor activation enhanced the suppressive function of mesenchymal stem cells against splenocyte proliferation.

Perfluoroalkyl Substances

Effect of gestational exposure to perfluorononanoic acid on neonatal mice testes.

Acute exposure to perfluorononanoic acid in prepubertal mice: Effect on germ cell dynamics and an insight into the possible mechanisms of its inhibitory action on testicular functions.

Flame Retardants

Complex Interplay Among Nuclear Receptor Ligands, Cytosine Methylation, and the Metabolome in Driving Tris(1,3-Dichloro-2-Propyl) Phosphate-Induced Epiboly Defects in Zebrafish.

Polybrominated Diphenylether (DE-71) Exposure Skews Phenotypic Sex Ratio, and Alters Steroid Hormone Levels and Steroidogenic Enzyme Activities in Juvenile Silurana tropicalis.

Effects of BDE-47 exposure on immune-related parameters of Mytilus galloprovincialis.

TDCIPP exposure affects Artemia franciscana growth and osmoregulation.

Pesticides

Organophosphorus pesticide triazophos: A new endocrine disruptor chemical of hypothalamus-pituitary-adrenal axis.

Low dose of flurochloridone affected reproductive system of male rats but not fertility and early embryonic development.

Biochemical and endocrine-disrupting effects in Clarias gariepinus exposed to the synthetic pyrethroids, cypermethrin and deltamethrin.

Effects of multiple stressors associated with agriculture on stream macroinvertebrate communities in a tropical catchment.

Glyphosate does not substitute for glycine in proteins of actively dividing mammalian cells.

Age- and diet-specific effects of chronic exposure to chlorpyrifos on hormones, inflammation and gut microbiota in rats.

Propolis relieves the cardiotoxicity of chlorpyrifos in diabetic rats via alleviations of paraoxonase-1 and xanthine oxidase genes expression.

Toxicity assessment of chlorpyrifos on different organs of rat: exploitation of microbial-based enzymatic system for neutralization.

Arsenic/Metals

Mercury in the retina and optic nerve following prenatal exposure to mercury vapor.

Chlorogenic acid attenuates cadmium-induced intestinal injury in Sprague-Dawley rats.

The Association Between Thyroid Injury and Apoptosis, and Alterations of Bax, Bcl-2, and Caspase-3 mRNA/Protein Expression Induced by Nickel Sulfate in Wistar Rats.

Arsenic impairs GLUT1 trafficking through the inhibition of the calpain system in lymphocytes.

Varied doses and chemical forms of selenium supplementation differentially affect mouse intestinal physiology.

Manganese attenuates the effects of arsenic on neurobehavioral and biochemical changes in mice co-exposed to arsenic and manganese.

In vitro and in vivo effects of a mycotoxin, deoxynivalenol, and a trace metal, cadmium, alone or in a mixture on the intestinal barrier.

Air Pollution

Hydrophobic organic components of ambient fine particulate matter (PM2.5) are associated with inflammatory cellular response.

Microplastics

Acute and chronic effects of polystyrene microplastics on juvenile and adult Daphnia magna.

Amino modification enhances reproductive toxicity of nanopolystyrene on gonad development and reproductive capacity in nematode Caenorhabditis elegans.

Organotins

Dna fragmentation factor 40 expression in T cells confer sensibility to tributyltin-induced apoptosis.

Miscellaneous

Developmental programming: Contribution of Epigenetic Enzymes to Antral Follicular Defects in the Sheep Model of PCOS.

Androgenic Regulation of Sexually Dimorphic Expression of RNA Binding Motif Protein 48 in the Developing Mouse Cortex and Hippocampus.

Wildlife/Environment/Exposure Studies

BPA/Phenols

Organophosphate flame retardants and bisphenol A in children’s urine in Hong Kong: has the burden been underestimated?

Bisphenol A in human saliva and urine before and after treatment with dental polymer-based restorative materials.

Distribution and ecological risk assessment of PEDCs in the water, sediment and Carex cinerascens of Poyang Lake wetland, China. [PEDC = phenolic endocrine disrupting chemical]

Ultra-processed food consumption and exposure to phthalates and bisphenols in the US National Health and Nutrition Examination Survey, 2013-2014.

Phthalates

Children’s exposure to phthalates and non-phthalate plasticizers in the home: The TESIE study.

Impact of organic contaminants from dumpsite leachates on natural water sources in the Enugu Metropolis, southeastern Nigeria. [phthalates etc.]

[Changes in Status of Plasticizers Used in Polyvinyl Chloride Toys]. [in Japanese]

Parabens/Triclosan/Antimicrobials

Examination of paraben release from baby teethers through migration tests and GC-MS analysis using a stable isotope dilution assay.

Persistent Organic Pollutants

Determinants of persistent organic pollutant (POP) concentrations in human breast milk of a cross-sectional sample of primiparous mothers in Belgium.

Bioaccumulation of PCDD/Fs in foodstuffs near Bien Hoa and Da Nang airbases: assessment on sources and distribution.

Bioaccumulation of persistent organic pollutants and their trophic transfer through the food web: Human health risks to the rural communities reliant on fish from South Africa’s largest floodplain.

Distribution, diastereomer-specific accumulation and associated health risks of hexabromocyclododecanes (HBCDs) in soil-vegetable system of the Pearl River Delta region, South China.

Trace elements and polychlorinated biphenyls (PCBs) in terrestrial compartments of Svalbard, Norwegian Arctic.

Are vitamins A and E associated with persistent organic pollutants and fatty acids in the blubber of highly contaminated killer whales (Orcinus orca) from Greenland?

Assessment of DDT and mercury levels in fish and sediments in the Iriri River, Brazil: Distribution and ecological risk.

Perfluoroalkyl Substances

Spatial and Interspecies Heterogeneity in Concentrations of Perfluoroalkyl Substances (PFASs) in Seabirds of the Southern Ocean.

Vertical transport and sinks of perfluoroalkyl substances in the global open ocean.

Preliminary assessment of general population exposure to perfluoroalkyl substances through diet in Greece.

Legacy and emerging perfluorinated and polyfluorinated compounds: An update.

Flame Retardants

Polybrominated Diphenyl Ethers in Surface Soils from the Yellow River Delta Natural Reserve, China: Occurrence, Sources, and Potential Risk.

Pesticides

Migration of cypermethrin to and through the PET containers and artificial neural network-based estimation of its emission.

Arsenic/Metals

Microbially-mediated release of As from Mekong Delta peat sediments.

Content of metals in emissions from gasoline, diesel, and alternative mixed biofuels.

Street dust heavy metal pollution implication on human health in Nicosia, North Cyprus.

Urinary Metal Levels with Relation to Age, Occupation, and Smoking Habits of Male Inhabitants of Eastern Iran.

Biomonitoring of airborne metals using tree leaves: Protocol for biomonitor selection and spatial trend.

Some toxic metals (Al, As, Mo, Hg) from cow’s milk raised in a possibly contaminated area by different sources.

Mercury in cetaceans: Exposure, bioaccumulation and toxicity.

Climate change and overfishing increase neurotoxicant in marine predators.

Relationship between the Use of Aluminium Utensils for Cooking Meals and Chronic Aluminum Toxicity in Patients on Maintenance Hemodialysis: A Case Control Study.

Stable isotope ratios of carbon, nitrogen and sulphur and mercury concentrations as descriptors of trophic ecology and contamination sources of Mediterranean whales.

Spatial distribution and ecological risk assessment of heavy metals in soil from the Raoyanghe Wetland, China.

Ecological risk analysis of the solid residues collected from the thermal disposal process of hyperaccumulator Pteris vittata including heavy metals and environmentally persistent free radicals.

Distribution, Contents, and Health Risk Assessment of Cadmium, Lead, and Nickel in Bananas Produced in Ecuador.

Pharmaceuticals

Trends in the occurrence and risk assessment of antibiotics in shallow lakes in the lower-middle reaches of the Yangtze River basin, China.

Occurrence, Seasonal Variation and Risk Assessment of Antibiotics in the Surface Water of North China.

Microplastics, Macroplastics, Pyroplastics

Microplastics as both a Sink and a Source of Bisphenol A in the Marine Environment.

Marine pollution from pyroplastics.

Spatial distribution of meso and microplastics in the sediments of river Ganga at eastern India.

Miscellaneous

Sources of and solutions to mistrust of tap water originating between treatment and the tap: Lessons from Los Angeles County.

Cleaning workers’ exposure to volatile organic compounds and particulate matter during floor polish removal and reapplication.

Prospects for finding Junge variability-lifetime relationships for micropollutants in the Danube river.

The pristine nature of river Ganges: its qualitative deterioration and suggestive restoration strategies.

Occurrence and health risk assessment of pharmaceutical and personal care products (PPCPs) in tap water of Shanghai.

This list is not meant to be exhaustive, and generally does not include studies on detection, remediation, or treatment of EDCs. Note that journal publication dates may be different than dates added to PubMed. Compiled by Sarah Howard, Diabetes and Environment Program and HEEDS at Commonweal.

EHN EHN

Webinar: Fluoride, neurodevelopment, and cognition: a National Toxicology Program monograph
by Sarah Howard on November 19, 2024 at 5:00 pm
This Dec. 3 webinar features Dr. Kyla Taylor of NIEHS who will discuss the results of a National Toxicology Program monograph review that concluded there is "moderate confidence" in the scientific evidence that showed an association between higher levels of fluoride exposure and lower IQ in children.
Webinar: Behind the scenes at EPA: What's gone wrong and what does it mean for our work?
by Sarah Howard on November 19, 2024 at 3:56 pm
This Dec. 9 webinar, Behind the scenes at EPA: what's gone wrong and what does it mean for our work? is part 2 of a series on the future of EPA decision-making. Sponsored by the Collaborative for Health and Environment (CHE), Earthjustice, and UCSF's Earth Center.
Endocrine-disrupting chemicals: hazards and opportunities (ECHO) course
by Sarah Howard on October 31, 2024 at 2:50 pm
This course focuses on the chemical, biological, and societal challenges of endocrine-disrupting chemicals (EDCs) and new opportunities for moving forward. ECHO is a two-week intensive bootcamp-style career development course for graduate students, postdoctoral fellows, and professionals in the field. It is held at Woods Hole, Massachusetts.

EHN EHN

“We have enough evidence” to act on toxic plastic exposure now
by Katherine McMahon,Sarah Howard on November 22, 2024 at 3:31 pm
In a recent commentary published in The Lancet, Dr. Leonardo Trasande of NYU’s Grossman School of Medicine emphasizes the need to address the well-established health harms from exposure to chemical additives used in plastics. “Only through a serious and concerted effort to turn off the plastic tap will we apply the lessons learned from plastic use… and avoid the invisible chemicals used in plastic materials from becoming visible in the form of a larger global pandemic of chronic disease.”
Kids who adopt a gluten-free diet have increased arsenic levels
by Katherine McMahon,Sarah Howard on November 20, 2024 at 1:32 pm
A recent study published in The American Journal of Gastroenterology found that children who adopted a gluten-free (GF) diet after being diagnosed with celiac disease had significantly increased arsenic exposure after only six months. “More research needs to be done to determine whether there are long-term effects of this bump, but overall, I think it speaks to the importance of diversifying the grains in the gluten-free diet.”
NIEHS publishes new strategic plan
by Sarah Howard on November 19, 2024 at 6:03 pm
The National Institute of Environmental Health Sciences (NIEHS) published a 2025-2029 strategic plan, "Health at the Intersection of People and Their Environments."

EHN EHN

Trump’s second term could mean fewer protections for drinking water
by EHN Curators on November 21, 2024 at 12:30 pm
Donald Trump’s plans for the Environmental Protection Agency may include rolling back protections against PFAS and other drinking water threats, worrying public health advocates. Hiroko Tabuchi reports for The New York Times.
Kennedy’s fluoride policy faces obstacles
by EHN Curators on November 19, 2024 at 8:28 pm
President-elect Trump’s selection of Robert F. Kennedy Jr. to lead the Department of Health and Human Services won’t give him direct control over water fluoridation policies, though his influence could sway public and local debates. Miranda Willson reports for E&E News.
Scientists' Declaration for the Global Plastics Treaty
by Sarah Howard on November 19, 2024 at 5:54 pm
The signatories of this declaration are independent scientists with expertise on plastics, and who are free of conflicts of interest associated with the life cycle of plastics. Read it here and sign it here. Due Nov. 22, 2024.