New EDC articles, July 24 – 30, 2019

A summary of articles on endocrine disrupting chemicals (EDCs) added to PubMed this week.

Contents: Interesting Research of the Week, Regulations/Policy, Reviews, Human Health Studies, Laboratory Studies, and Wildlife/Environment/Exposure Studies.

Interesting Research of the Week

A curated knowledgebase on endocrine disrupting chemicals and their biological systems-level perturbations. [built a Database of Endocrine Disrupting Chemicals and their Toxicity profiles (DEDuCT) of 686 potential EDCs, accessible at: https://cb.imsc.res.in/deduct/]

Regulations/Policy

ToxRefDB version 2.0: Improved utility for predictive and retrospective toxicology analyses.

Recommendations for Reducing the USE of Fish and Amphibians in Endocrine-Disruption Testing of Biocides and Plant Protection Products in Europe.

Combating EPA Rollbacks – Health Care’s Response to a Retreat on Climate. [Perspective article in NEJM]

Reviews

Phthalate exposure and female reproductive and developmental outcomes: a systematic review of the human epidemiological evidence.

Developmental Programming of PCOS Traits: Insights from the Sheep.

Lipotoxicity, neuroinflammation, glial cells and estrogenic compounds.

A Systematic Review on the Influences of Neurotoxicological Xenobiotic Compounds on Inhibitory Control

Mitochondrial DNA: Epigenetics and Environment.

A critical evaluation of thyroid hormone measurements in OECD test guideline studies: Is there any added value?

Persistent Organic Pollutants

The effect of the transition from elemental chlorine bleaching to chlorine dioxide bleaching in the pulp industry on the formation of PCDD/Fs.

A review of sources, environmental occurrences and human exposure risks of hexachlorobutadiene and its association with some other chlorinated organics.

Pesticides

Exposure to glyphosate-based herbicides and risk for non-Hodgkin lymphoma: A meta-analysis and supporting evidence.

Arsenic/Metals

Long-term accumulation of metals in the skeleton as related to osteoporotic derangements.

Arsenic Neurotoxicity in Humans.

Autism spectrum disorder and mercury toxicity: use of genomic and epigenetic methods to solve the etiologic puzzle.

Human Health Studies

BPA/Phenols

Urinary bisphenols and obesity prevalence among US children and adolescents

Phthalates

Prenatal exposure to phthalates and neurocognitive development in children at two years of age.

Pesticides

Evaluation of cholinesterase and lipid profile levels in chronic pesticide exposed persons.

Effects of pesticides on rural workers: haematological parameters and symptomalogical reports.

Agricultural exposures to carbamate herbicides and fungicides and central nervous system tumour incidence in the cohort AGRICAN.

Exposure to pesticides and welding hastens the age-at-onset of Parkinson’s disease.

Characterizing the joint effects of pesticide exposure and criteria ambient air pollutants on pediatric asthma morbidity in an agricultural community.

Arsenic/Metals

Biochemical investigation of association of arsenic exposure with risk factors of diabetes mellitus in Pakistani population and its validation in animal model.

Blood Arsenic Levels and the Risk of Familial Breast Cancer in Poland.

Air Pollution

Association of School Residential PM2.5 with Childhood High Blood Pressure: Results from an Observational Study in 6 Cities in China.

Spatial Clusters of Children with Cleft Lip and Palate and Their Association with Polluted Zones in the Monterrey Metropolitan Area.

Effects of policy-driven hypothetical air pollutant interventions on childhood asthma incidence in southern California.

Relative toxicities of major particulate matter constituents on birthweight in Massachusetts.

Laboratory Studies

BPA/Phenols

Developmental programming: Sex-specific programming of growth upon prenatal bisphenol A exposure. [in sheep]

Long-term exposure to bisphenol A or S promotes glucose intolerance and changes hepatic mitochondrial metabolism in male Wistar rats.

Effect of bisphenol-A (BPA) on placental biomarkers for inflammation, neurodevelopment and oxidative stress.

Effect of antioxidants on BPA-induced stress on sperm function in a mouse model.

New insights into mechanism of bisphenol analogue neurotoxicity: implications of inhibition of O-GlcNAcase activity in PC12 cells.

Influence of N-acetyl-L-cysteine against bisphenol a on the maturation of mouse oocytes and embryo development: in vitro study.

Assessment of the Effective Impact of Bisphenols on Mitochondrial Activity and Steroidogenesis in a Dose-Dependency in Mice TM3 Leydig Cells.

Embryonic Exposure to Bisphenol A Impairs Primordial Germ Cell Migration without Jeopardizing Male Breeding Capacity.

Phthalates

Di-2-Ethylhexyl Phthalate Induces Ovarian Toxicity and Alters Protein Expression of Hormone-regulated Receptors in Rats.

Mono (2-ethylhexyl) phthalate (MEHP) triggers the proliferation of hemangioma-derived endothelial cells via YAP signals.

Persistent Organic Pollutants

Developmental exposure to polychlorinated biphenyls (PCBs) in the maternal diet causes host-microbe defects in weanling offspring mice.

Regulation of Proliferative Processes in Rat Adrenal Cortex by Transcriptional Factor PRH under Conditions of Developmental Exposure to Endocrine Disruptor DDT.

Perfluoroalkyl Substances

Toxicokinetics of perfluorobutane sulfonate (PFBS), perfluorohexane-1-sulphonic acid (PFHxS), and perfluorooctane sulfonic acid (PFOS) in male and female Hsd:Sprague Dawley SD rats after intravenous and gavage administration.

Investigation of binding and activity of perfluoroalkyl substances to the human peroxisome proliferator-activated receptor β/δ.

Neurodevelopmental and Metabolomic Responses from Prenatal Co-Exposure to Perfluorooctane Sulfonate (PFOS) and Methylmercury (MeHg) in Sprague-Dawley Rats.

Flame Retardants

Early life exposure to triphenyl phosphate: Effects on thyroid function, growth, and resting metabolic rate of Japanese quail (Coturnix japonica) chicks.

Pesticides

Gestational Exposure to Pesticides Induces Oxidative Stress and Lipid Peroxidation in Offspring that Persist at Adult Age in an Animal Model.

Mitochondrial dysfunction, apoptosis and transcriptomic alterations induced by four strobilurins in zebrafish (Danio rerio) early life stages.

Arsenic/Metals

Chronic Mercury Exposure in Prehypertensive SHRs Accelerates Hypertension Development and Activates Vasoprotective Mechanisms by Increasing NO and H2O2 Production.

Arsenite and its trivalent methylated metabolites inhibit glucose-stimulated calcium influx and insulin secretion in murine pancreatic islets.

Metformin in contrast to berberine reversed arsenic-induced oxidative stress in mitochondria from rat pancreas probably via Sirt3-dependent pathway.

Subchronic Oral Cadmium Exposure Exerts both Stimulatory and Suppressive Effects on Pulmonary Inflammation/Immune Reactivity in Rats.

Melatonin prevents cadmium-induced bone damage: first evidence on an improved osteogenic/adipogenic differentiation balance of mesenchymal stem cells as underlying mechanism.

Phenol-Rich Feijoa sellowiana (Pineapple Guava) Extracts Protect Human Red Blood Cells from Mercury-Induced Cellular Toxicity.

No detectable changes in crayfish behavior due to sublethal dietary mercury exposure.

Dietary compounds to reduce in vivo inorganic arsenic bioavailability.

The cardiotoxicity of the common carp (Cyprinus carpio) exposed to environmentally relevant concentrations of arsenic and subsequently relieved by zinc supplementation.

Prevention of cadmium-induced neurotoxicity in rats by essential nutrients present in nuts.

Cadmium exposure induces pancreatic β-cell death via a Ca2+-triggered JNK/CHOP-related apoptotic signaling pathway.

Comparisons among Machine Learning Models for the Prediction of Hypercholestrolemia Associated with Exposure to Lead, Mercury, and Cadmium.

Maternal metabolic syndrome and selenium: Endocrine energy balance during early programming.

Cadmium as main endocrine disruptor in papillary thyroid carcinoma and the significance of Cd/Se ratio for thyroid tissue pathophysiology.

Air Pollution

Diesel Exhaust Induces Mitochondrial Dysfunction, Hyperlipidemia and Liver Steatosis.

Miscellaneous

Binding of iodinated contrast media (ICM) and their transformation products with hormone receptors: Are ICM the new EDCs?

Oligodendrocyte involvement in Gulf War Illness.

DNA Damage and Perturbed Topoisomerase IIα as a Target of 1,4-Benzoquinone Toxicity in Murine Fetal Liver Cells.

Toxicokinetics and bioavailability of sulfolane, a ground water contaminant, following oral and intravenous administration in rodents: A dose, species, and sex comparison.

Estrone exposure interacts with temperature to alter predator evasion performance and systemic mRNA abundances.

Wildlife/Environment/Exposure Studies

BPA/Phenols

Simultaneous analysis of bisphenol A fractions in maternal and fetal compartments in early second trimester of pregnancy.

Occurrence and distribution of parabens and bisphenols in sediment from northern Chinese coastal areas.

Persistent Organic Pollutants

Environmental chemical exposures among Greenlandic children in relation to diet and residence. [PCBs, PFASs, mercury]

Study Design, Rationale and Procedures for Human Biomonitoring of Hazardous Chemicals from Foods and Cooking in Korea. [POPs, PFCs, phenols, phthalates, etc.]

The human body burden of polychlorinated dibenzo-p-dioxins/furans (PCDD/Fs) and dioxin-like polychlorinated biphenyls (DL-PCBs) in residents’ human milk from Guangdong Province, China.

DNA Double-Strand Breaks in Arctic Charr (Salvelinus alpinus) from Bjørnøya in the Norwegian Arctic.

Perfluoroalkyl Substances

Notes from the Field: Targeted Biomonitoring for GenX and Other Per- and Polyfluoroalkyl Substances Following Detection of Drinking Water Contamination – North Carolina, 2018.

Perfluoroalkyl Acids in Great Lakes Precipitation and Surface Water (2006-2018) Indicate Response to Phase-outs, Regulatory Action, and Variability in Fate and Transport Processes.

Spatial and temporal variability of perfluoroalkyl substances in the Laurentian Great Lakes.

Flame Retardants

Spatiotemporal distribution, source apportionment and ecological risk assessment of PBDEs and PAHs in the Guanlan River from rapidly urbanizing areas of Shenzhen, China.

Recent findings of halogenated flame retardants (HFR) in the German and Polar environment.

Pesticides

Methods for the Identification of Outliers and Their Influence on Exposure Assessment in Agricultural Pesticide Applicators: A Proposed Approach and Validation Using Biological Monitoring.

Arsenic/Metals

The Existence of Airborne Mercury Nanoparticles.

Pediatric reference values for chromium and mercury in urine in the City of Buenos Aires and Greater Buenos Aires.

Miscellaneous

Insights into the Potential of the Atlantic Cod Gut Microbiome as Biomarker of Oil Contamination in the Marine Environment

This list is not meant to be exhaustive, and generally does not include studies on detection, remediation, or treatment of EDCs. Note that journal publication dates may be different than dates added to PubMed. Compiled by Sarah Howard, Diabetes and Environment Program and HEEDS at Commonweal.