New EDC articles, July 17 – 23, 2019 – HEEDS

New EDC articles, July 17 – 23, 2019

Post author:HEEDS
Post published:July 23, 2019
Post category:EDC Science Weekly

A summary of articles on endocrine disrupting chemicals (EDCs) added to PubMed this week.

Contents: Screening/New Approaches, Reviews, Human Health Studies, Laboratory Studies, and Wildlife/Environment/Exposure Studies.

Screening/New Approaches

Identification of potential endocrine disrupting chemicals using gene expression biomarkers.

Determining the endocrine disruption potential of industrial chemicals using an integrative approach: Public databases, in vitro exposure, and modeling receptor interactions.

Determination of chemical-disease risk values to prioritize connections between environmental factors, genetic variants, and human diseases.

Testing the Thresholds of Toxicological Concern Values Using a New Database for Food-Related Substances.

The zebrafish embryotoxicity test (ZET) for nanotoxicity assessment: from morphological to molecular approach.

Methods to Test Endocrine Disruption in Drosophila melanogaster.

Proposed Key Characteristics of Female Reproductive Toxicants as an Approach for Organizing and Evaluating Mechanistic Data in Hazard Assessment.

sAOP: Linking chemical stressors to Adverse Outcomes Pathway Networks.

Reviews

Advancing science in rapidly changing environments: opportunities for the Central and Eastern European Conference on Health and the Environment to connect to other networks.

Fetal toxicology.

Environmental and health risks related to waste incineration.

BPA

The Association between Bisphenol A Exposure and Obesity in Children-A Systematic Review with Meta-Analysis.

Pesticides

Pesticide interactions and risks of sperm chromosomal abnormalities.

Air Pollution

Air Pollution, Oxidative Stress, and Diabetes: a Life Course Epidemiologic Perspective.

Long-term exposure to PM2.5 and stroke: A systematic review and meta-analysis of cohort studies.

Human Health Studies

BPA/Phenols

Bisphenol A, chlorinated derivatives of Bisphenol A and occurrence of myocardial infarction in patients with type 2 diabetes: nested case-control studies in two European cohorts.

Phthalates

Effect of exposure to phthalates on association of polycyclic aromatic hydrocarbons with 8-hydroxy-2′-deoxyguanosine.

Persistent Organic Pollutants

Serum levels of Organochlorine Pesticides and Breast Cancer Risk in Iranian Women.

Prenatal exposure to Polychlorinated Biphenyls and body fatness in girls.

Perfluoroalkyl Substances

In Utero Exposure to Poly and Perfluoroalkyl Substances (PFASs) and Subsequent Breast Cancer.

Prenatal exposure to chlorinated polyfluoroalkyl ether sulfonic acids and perfluoroalkyl acids: Potential role of maternal determinants and associations with birth outcomes.

Flame Retardants

Multiple exposures to organophosphate flame retardants alter urinary oxidative stress biomarkers among children: The Hokkaido Study.

Associations of prenatal exposures to low levels of Polybrominated Diphenyl Ether (PBDE) with thyroid hormones in cord plasma and neurobehavioral development in children at 2 and 4 years.

Health Toll From Open Flame and Cigarette-Started Fires on Flame-Retardant Furniture in Massachusetts, 2003-2016.

Pesticides

A permethrin metabolite is associated with adaptive immune responses in Gulf War Illness.

Arsenic/Metals

Combined exposure to lead, cadmium, mercury, and arsenic and kidney health in adolescents age 12-19 in NHANES 2009-2014.

Neurocognitive impact of metal exposure and social stressors among schoolchildren in Taranto, Italy.

Exposure of metals and PAH through local foods and risk of cancer in a historically contaminated glassworks area.

A Metallomic Approach to Assess Associations of Serum Metal Levels With Gallstones and Gallbladder Cancer.

The association of urine metals and metal mixtures with cardiovascular incidence in an adult population from Spain: the Hortega Follow-Up Study.

Mixtures

Congenital heart defects and intensity of oil and gas well site activities in early pregnancy.

Do Gulf War veterans with high levels of deployment-related exposures display symptoms suggestive of Parkinson’s disease?

Air Pollution

Prenatal and postnatal exposure to air pollution and emotional and aggressive symptoms in children from 8 European birth cohorts.

Particulate matter air pollution and blood glucose in children and adolescents: A cross-sectional study in China.

Urinary metabolites of polycyclic aromatic hydrocarbons in pregnant women and their association with a biomarker of oxidative stress.

Laboratory Studies

BPA/Phenols

Oral Systemic Bioavailability of Bisphenol A and Bisphenol S in Pigs.

Bisphenol A Regulates Sodium Ramp Currents in Mouse Dorsal Root Ganglion Neurons and Increases Nociception.

Developmental low-dose exposure to bisphenol A induces chronic inflammation, bone marrow fibrosis and reduces bone stiffness in female rat offspring only.

Dichotomy of bisphenol A-induced expression of peroxisome proliferator-activated receptors in hepatic and testicular tissues in mice.

Retraction: Perinatal Exposure to Bisphenol-A Impairs Spatial Memory through Upregulation of Neurexin1 and Neuroligin3 Expression in Male Mouse Brain.

Adverse Effect of Nonylphenol on the Reproductive System in F1 Male Mice: A Subchronic Low-Dose Exposure Model.

Phthalates

Phthalate plasticizer di(2-ethyl-hexyl) phthalate induces cyclooxygenase-2 expression in gastric adenocarcinoma cells.

In vitro toxicity of dimethyl phthalate to human erythrocytes: From the aspects of antioxidant and immune functions.

Environmentally Relevant Exposure to Dibutyl Phthalate Disrupts DNA Damage Repair Gene Expression in the Mouse Ovary.

Benzyl butyl phthalate non-linearly affects rat Leydig cell development during puberty.

Triclosan

Metabolomics and phenotype assessment reveal cellular toxicity of triclosan in Caenorhabditis elegans.

Persistent Organic Pollutants

Persistent organic pollutants (POPs) increase rage signaling to promote downstream cardiovascular remodeling.

Perfluoroalkyl Substances

Acute and chronic effects of perfluoroalkyl substance mixtures on larval American bullfrogs (Rana catesbeiana).

Subchronic exposure of environmentally relevant concentrations of F-53B in mice resulted in gut barrier dysfunction and colonic inflammation in a sex-independent manner.

Flame Retardants

Thyroid Hormone Disruptors Interfere with Molecular Pathways of Eye Development and Function in Zebrafish. [tetrabromobisphenol-A (TBBPA)]

BDE-209 induces autophagy and apoptosis via IRE1α/Akt/mTOR signaling pathway in human umbilical vein endothelial cells.

Pesticides

Xenobiotic mediated diabetogenesis: Developmental exposure to dichlorvos or atrazine leads to type 1 or type 2 diabetes in drosophila.

Glyphosate-based herbicide exposure during pregnancy and lactation malprograms the male reproductive morphofunction in F1 offspring.

Single and joint effects of chronic exposure to chlorpyrifos and glyphosate based pesticides on structural biomarkers in Cnesterodon decemmaculatus.

Glyphosate-based herbicide exposure during pregnancy and lactation malprograms the male reproductive morphofunction in F1 offspring.

Chlorpyrifos induced oxidative stress to promote apoptosis and autophagy through the regulation of miR-19a-AMPK axis in common carp.

Mitochondria as a target of organophosphate and carbamate pesticides: revisiting common mechanisms of action with new approach methodologies

Determination of offspring NOAEL for zeta-cypermethrin using internal exposure data from rat developmental neurotoxicity studies.

Reprotoxicity of glyphosate-based formulation in Caenorhabditis elegans is not due to the active ingredient only.

Neurotoxicity of organophosphate pesticides could reduce the ability of fish to escape predation under low doses of exposure.

Enantiomeric analysis of pyrethroids and organophosphorus insecticides.

Effects of 2,4-D-based herbicide (DMA® 806) on sensitivity, respiration rates, energy reserves and behavior of tadpoles.

A sublethal dose of the neonicotinoid insecticide acetamiprid reduces sperm density in a songbird.

Potential benefits of polysaccharides derived from marine alga Ulva lactuca against hepatotoxicity and nephrotoxicity induced by thiacloprid, an insecticide pollutant.

Arsenic/Metals

Chronic exposure to Pb2+ perturbs ChREBP transactivation and coerces Hepatic Dyslipidemia.

Arsenic exposure during prepuberty alters prostate maturation in pubescent rats.

Influence of oral administration of Akkermansia muciniphila on the tissue distribution and gut microbiota composition of acute and chronic cadmium exposure mice.

In vivo evaluation of the effect of arsenite on the intestinal epithelium and associated microbiota in mice.

The Footprints of Oxidative Stress and Mitochondrial Impairment in Arsenic Trioxide-Induced Testosterone Release Suppression in Pubertal and Mature F1-Male Balb/c Mice via the Downregulation of 3β-HSD, 17β-HSD, and CYP11a Expression.

Inorganic arsenic causes intestinal barrier disruption.

Paternal exposure to arsenic resulted in oxidative stress, autophagy, and mitochondrial impairments in the HPG-S axis of pubertal male offspring.

Chronic lead (Pb) exposure results in diminished hemocyte count and increased susceptibility to bacterial infection in Drosophila melanogaster.

Reproductive toxicity of acute Cd exposure in mouse: Resulting in oocyte defects and decreased female fertility.

Decreased Insulin Secretion but Unchanged Glucose Homeostasis in Cadmium-Exposed Male C57BL/6 Mice.

Gene expression and DNA methylation regulation of arsenic in mouse bladder tissues and in human urothelial cells.

Methylmercury exposure induces ROS/Akt inactivation-triggered endoplasmic reticulum stress-regulated neuronal cell apoptosis.

Microplastics

Accumulation of different shapes of microplastics initiates intestinal injury and gut microbiota dysbiosis in the gut of zebrafish.

Impact of nano-sized plastic on the nutritional value and gut microbiota of whiteleg shrimp Litopenaeus vannamei via dietary exposure.

Evaluation of single and combined effects of cadmium and micro-plastic particles on biochemical and immunological parameters of common carp (Cyprinus carpio).

Pharmaceuticals

Sex-specific changes in gene expression in response to estrogen pollution around the onset of sex differentiation in grayling (Salmonidae).

The classic azole antifungal drugs are highly potent endocrine disruptors in vitro inhibiting steroidogenic CYP enzymes at concentrations lower than therapeutic Cmax.

Oral exposure of rats to dienestrol during gestation and lactation: Effects on the reproductive system of male offspring.

Wildlife/Environment/Exposure Studies

Persistent Organic Pollutants

Concentrations of organohalogens (PCBs, DDTs, PBDEs) in hunted and stranded Northern sea otters (Enhydra lutris kenyoni) in Alaska from 1992 to 2010: Links to pathology and feeding ecology.

Persistent contaminants as potential constraints on the recovery of urban river food webs from gross pollution.

Statistical Approach for Assessing the Stockholm Convention’s Effectiveness: Great Lakes Atmospheric Data.

Flame Retardants

Concentrations of Brominated Flame Retardants in Indoor Air and Dust from Ireland reveal elevated exposure to Decabromodiphenyl Ethane.

Towards establishing indicative values for metabolites of organophosphate ester contaminants in human urine.

Pesticides

Effect of a 24-week randomized trial of an organic produce intervention on pyrethroid and organophosphate pesticide exposure among pregnant women.

Ecological Risk Assessment (ERA) of pesticides from freshwater ecosystems in the Pampas region of Argentina: Legacy and current use chemicals contribution.

Assessment of pesticides in soil from obsolete pesticides stores: a Caribbean case study.

Arsenic/Metals

Environmental risk related to presence and mobility of As, Cd and Tl in soils in the vicinity of a metallurgical plant – Long-term observations.

Collaborative response to arsenic-contaminated soil in an Appalachian Kentucky neighborhood.

Global evaluation of heavy metal content in surface water bodies: A meta-analysis using heavy metal pollution indices and multivariate statistical analyses.

Assessment of placental metal levels in a South African cohort.

Determination of the selected heavy metal and metalloid contents in various types of plastic bags.

Using human hair and nails as biomarkers to assess exposure of potentially harmful elements to populations living near mine waste dumps.

Microplastics

Current practices and future perspectives of microplastic pollution in freshwater ecosystems in China.

Microplastics as contaminants in the soil environment: A mini-review.

First evidence of microplastic contamination in the supraglacial debris of an alpine glacier.

Miscellaneous

Short-chain chlorinated paraffins in fish from two developed regions of China: Occurrence, influencing factors and implication for human exposure via consumption.

Indoor Air Pollution in Cars: An Update on Novel Insights.

Assessment of Traffic-Related Air Pollution: Case Study of Pregnant Women in South Texas.

This list is not meant to be exhaustive, and generally does not include studies on detection, remediation, or treatment of EDCs. Note that journal publication dates may be different than dates added to PubMed. Compiled by Sarah Howard, Diabetes and Environment Program and HEEDS at Commonweal.

EHN EHN

Endocrine-disrupting chemicals: hazards and opportunities (ECHO) course
by Sarah Howard on October 31, 2024 at 2:50 pm
This course focuses on the chemical, biological, and societal challenges of endocrine-disrupting chemicals (EDCs) and new opportunities for moving forward. ECHO is a two-week intensive bootcamp-style career development course for graduate students, postdoctoral fellows, and professionals in the field. It is held at Woods Hole, Massachusetts.
Lou Guillette Jr. Memorial Symposium
by Sarah Howard on October 22, 2024 at 1:30 pm
On March 14-15, 2025, HEEDS is hosting the Lou Guillette Jr. Memorial Symposium on endocrine disrupting science at the University of Florida. It will celebrate the life and legacy of Dr. Guillette, gather together his trainees and colleagues, and focus on the research topics that Lou made famous. Information here.
Webinar: The overturning of Chevron deference: impacts on environmental health decision making
by Sarah Howard on October 17, 2024 at 4:21 pm
In this Nov. 13 webinar, legal experts will discuss the implications of the overturning of Chevron deference and its profound impact on science, public health and decision-making. Sponsored by CHE and UCSF's EaRTH Center.

EHN EHN

Ultra-processed foods and plastic packaging make for the ultimate toxic pair, scientists say
by Katherine McMahon,Sarah Howard on October 25, 2024 at 10:37 am
A recent paper published in Globalization and Health explores the relationship between ultra-processed foods (UPFs), plastic packaging, and their combined threat to public health. “Consumers do not have the power to solve a problem of this scale, and thus it is the responsibility of policymakers to ensure that transitions away from unhealthy, unsustainable foods are accompanied by structural measures that support demand and access to healthy foods.”
Microplastic exposure linked to reduced sperm quality in humans
by Katherine McMahon,Sarah Howard on October 23, 2024 at 4:29 pm
Exposure to microplastics is associated with a decrease in sperm concentration, motility, and shape, according to a new study published in The Lancet. “The identification of non-stick pan coating material PTFE as a particularly hazardous microplastic for male fertility underscores the importance of targeted interventions to reduce exposure to this and similar substances.”
Exposure to PFAS in ski wax may be linked to high cholesterol
by Katherine McMahon,Sarah Howard on October 16, 2024 at 7:42 pm
According to a new study published in Environmental Research, skiers and snowboarders may face health risks from their exposure to PFAS via ski wax, which can contain up to 100% PFAS by mass. “Interventions to remove PFAS from fluorinated wax could decrease direct exposure to skiers and reduce PFAS release into the environment.”

EHN EHN

Stricter toxic chemical rules reduce Californians’ exposures
by Kristina Marusic on October 31, 2024 at 11:25 am
Californians have lower levels of toxic chemicals linked to cancer, birth defects and reproductive harm in their bodies than people in the rest of the country, according to a new study. The study, published in Environmental Health Perspectives and conducted by researchers at Silent Spring Institute, a nonprofit scientific research organization, and the University of California at Berkeley (UC Berkeley), looked at nationwide data on the levels of 37 toxic chemicals in people’s blood before and after California introduced its stringent regulations. It found that for 18 of these chemicals, Californians have lower levels in their bodies than the rest of the country.
EPA dismissed data on the neurotoxicity of common insecticides
by Katherine McMahon,Sarah Howard on October 30, 2024 at 5:56 pm
A recent paper in Frontiers in Toxicology examined research submitted by industry to the U.S. Environmental Protection Agency (EPA) on the neurotoxicity of neonicotinoids - the most widely used class of insecticides in the U.S. and worldwide - and found that the data was evaluated improperly by the agency. Why this matters: Neonicotinoids are widely used not only for commercial agriculture but also for more personal uses like home gardens and in some flea and tick treatments for pets. Humans are regularly exposed to neonicotinoids – which are structurally similar to nicotine – through the environment, food and water. Neonicotinoids’ popularity partly comes from the belief that their harmful effects are mostly limited to insects, but studies like this one demonstrate that mammals may also be harmed by the chemicals, and highlight the urgent need for stronger regulations around their use.
Pesticide regulations ignore critical threats to insect health and ecosystems
by EHN Curators on October 30, 2024 at 10:26 am
In a study revealing regulatory gaps, researchers found that pesticides impact insect behavior and survival at non-lethal doses, especially in warmer temperatures, calling into question the effectiveness of current pesticide safety protocols. Dave Goulson writes for The Conversation.