New EDC articles, July 3 – 9, 2019

A summary of articles on endocrine disrupting chemicals (EDCs) added to PubMed this week.

Contents: Interesting Research of the Week, Regulations/Policy, Reviews, Human Health Studies, Laboratory Studies, and Wildlife/Environment/Exposure Studies.

Interesting Research of the Week

Distract, delay, disrupt: examples of manufactured doubt from five industries.

Regulations/Policy

Changes in fish sex ratio as a basis for regulating endocrine disruptors.

Reviews

Epigenetic modifications associated with in utero exposure to endocrine disrupting chemicals BPA, DDT and Pb.

In silico predictions of endocrine disruptors properties.

The freshwater isopod Asellus aquaticus as a model biomonitor of environmental pollution: A review.

[Thyroid disruptors and their consequences on brain development and behavior]. [article in French]

Strategic reflections of the Spanish Society of Endocrinology and Nutrition on the future of the speciality in the period 2018-2022.

Towards sustainable environmental quality: Priority research questions for the australasian region of oceania.

Pollution, Obesity, Vitamin D, or Why Is Asthma So Complicated-and Interesting.

BPA/Phenols/Phthalates

Di(2-ethylhexyl) phthalate-induced toxicity and peroxisome proliferator-activated receptor alpha: a review.

PFAS

A review of sources, multimedia distribution and health risks of novel fluorinated alternatives.

Arsenic/Metals

Health effects inflicted by chronic low-level arsenic contamination in groundwater: A global public health challenge.

Animal Models of Intoxication by Metal Elements: A Focus on Neurobehavioral Injuries.

Immunotoxic effects of lead on birds.

Pesticides

The greenhouse work environment: a modifier of occupational pesticide exposure?

Neurotoxicity of Pesticides: The Roadmap for the Cubic Mode of Action.

Nanoparticles

A human whole-blood model to study the activation of innate immunity system triggered by nanoparticles as a demonstrator for toxicity.

Human Health Studies

Multiple Chemicals/Mixtures

Epidemiologically-informed cumulative risk hypertension models simulating the impact of changes in metal, organochlorine, and non-chemical exposures in an environmental justice community.

Seasonal modification of the associations of exposure to polycyclic aromatic hydrocarbons or phthalates of cellular aging.

Do emissions from landfill fires affect pregnancy outcomes? A retrospective study after arson at a solid waste facility in Sicily.

Phthalates

Phthalate Exposures, DNA Methylation and Adiposity in Mexican Children Through Adolescence.

Persistent Organic Pollutants

Prenatal and childhood exposure to chlordecone and sex-typed toy preference of 7-year-old Guadeloupean children.

Maternal exposures to persistent organic pollutants are associated with DNA methylation of thyroid hormone-related genes in placenta differently by infant sex.

Health risk of childhood exposure to PCDD/Fs emitted from a municipal waste incinerator in Zhejiang, China.

Perfluoroalkyl Substances

Prenatal exposure to perfluoroalkyl substances, immune-related outcomes, and lung function in children from a Spanish birth cohort study.

Complex relationships between perfluorooctanoate, body mass index, insulin resistance and serum lipids in young girls.

Pesticides

Occupational exposure to pesticides and hematological alterations: A survey of farm residents in the South of Brazil.

Arsenic/Metals

Heavy metals in fish and its association with autoimmunity in the development of juvenile idiopathic arthritis: a prospective birth cohort study.

Concentrations of Lead, Mercury, Arsenic, Cadmium, Manganese, and Aluminum in Blood of Romanian Children Suspected of Having Autism Spectrum Disorder.

Selenium status in lactating mothers-infants and its potential protective role against the neurotoxicity of methylmercury, lead, manganese, and DDT.

A prophylactic multi-strain probiotic treatment to reduce the absorption of toxic elements: In-vitro study and biomonitoring of breast milk and infant stools.

Air Pollution

Effects of ambient particulate matter on fasting blood glucose among primary school children in Guangzhou, China.

Time-Varying Exposure to Air Pollution and Outcomes of in Vitro Fertilization among Couples from a Fertility Clinic.

Long-Term Particulate Matter Exposure and Onset of Depression in Middle-Aged Men and Women.

Small but Mighty: Prenatal Ultrafine Particle Exposure Linked to Childhood Asthma Incidence.

Spatial variations in ambient ultrafine particle concentrations and risk of congenital heart defects.

Laboratory Studies

Multiple Chemicals

Morphometric signatures of exposure to endocrine disrupting chemicals in zebrafish eleutheroembryos. [BPA, PFOS, TBT]

Concomitant exposure to benzo[a]pyrene and triclosan at environmentally relevant concentrations induces metabolic syndrome with multigenerational consequences in Silurana (Xenopus) tropicalis.

Inhibition of Human Liver Carboxylesterase (hCE1) by Organophosphate Ester Flame Retardants and Plasticizers: Implications for Pharmacotherapy.

BPA/Phenols

Transgenerational effects of BPA on female reproduction.

Effects of Exposure to Bisphenol A during Pregnancy on the Pup Testis Function.

Bisphenol A induces cholesterol biosynthesis in HepG2 cells via SREBP-2/HMGCR signaling pathway.

Effects of bisphenol A on post-embryonic development of the cotton pest Spodoptera littoralis.

Effects of Bisphenol A on endogenous retroviral envelopes expression and trophoblast fusion in BeWo cells.

Testicular toxicity of orally administrated bisphenol A in rats and protective role of taurine and curcumin.

Dynamic monitoring of depressive behavior induced by nonylphenol and its effect on synaptic plasticity in rats.

Effects of nonylphenol administration on serum, liver and testis estrogen metabolism.

Phthalates

The effects on the endocrine system under hepatotoxicity induction by phenobarbital and di(2-ethylhexyl)phthalate in intact juvenile male rats.

Parabens/Triclosan/Antimicrobials

The methyl-triclosan induced caspase-dependent mitochondrial apoptosis in HepG2 cells mediated through oxidative stress.

Exposure to single and binary mixtures of fullerenes and triclosan: Reproductive and behavioral effects in the freshwater snail Radix balthica.

Persistent Organic Pollutants

Atropselective Oxidation of 2,2′,3,3′,4,6′-Hexachlorobiphenyl (PCB 132) to Hydroxylated Metabolites by Human Liver Microsomes and Its Implications for PCB 132 Neurotoxicity.

Effect of Dioxins in Milk on the 3D Cultured Primary Buffalo Hepatocyte Model System.

Cardiotoxicity induced by 2,3,7,8-tetrachlorodibenzo-p-dioxin exposure through lactation in mice.

Benzo[a]pyrene alters vascular function in rat aortas ex vivo and in vivo.

Perfluoroalkyl Substances

Perfluorobutanesulfonate Exposure Skews Sex Ratio in Fish and Transgenerationally Impairs Reproduction.

Pesticides

Melatonin protects against Fenoxaprop-ethyl exposure-induced meiotic defects in mouse oocytes.

DNA damage, acetylcholinesterase activity, and hematological responses in rainbow trout exposed to the organophosphate malathion.

Imbalances in the male reproductive function of the estuarine crabNeohelicegranulata, caused by glyphosate.

Cytochrome P450 and Glutathione-S-Transferase Activity are Altered Following Environmentally Relevant Atrazine Exposures in Crayfish (Faxoniusvirilis).

Effects of egg exposure to atrazine and/or glyphosate on bone development in Podocnemis unifilis (Testudines, Podocnemididae).

Study of Cu NPs reactivity for compounds with different chemical structures: Black reactive dye 5, picric acid and 2,4-D herbicide.

2,4-D causes oxidative stress induction and apoptosis in human dental pulp stem cells (hDPSCs).

In vitro inhibition of human CYP2D6 by the chiral pesticide fipronil and its metabolite fipronil sulfone: Prediction of pesticide-drug interactions.

Assessing predator-prey interactions in a chemically altered aquatic environment: the effects of DDT on Xenopus laevis and Culex sp. larvae interactions and behaviour.

Glyphosate induces benign monoclonal gammopathy and promotes multiple myeloma progression in mice.

Arsenic/Metals

High dose of standardised extract of Costus afer leaves potentiates cadmium reproductive toxicity in Wistar rats.

Co-administration of a Rhododendron tomentosum extract does not affect mercury tissue concentrations and excretion rate in methylmercury-treated adult male rats.

Arsenite interrupts neurodevelopmental processes of human and rat neural progenitor cells: The role of reactive oxygen species and species-specific antioxidative defense.

Phytohormones enabled endophytic Penicillium funiculosum LHL06 protects Glycine max L. from synergistic toxicity of heavy metals by hormonal and stress-responsive proteins modulation.

Use of a Mouse Model and Human Umbilical Vein Endothelial Cells to Investigate the Effect of Arsenic Exposure on Vascular Endothelial Function and the Associated Role of Calpains.

Dose-Dependent Acute Circulatory Fates Elicited by Cadmium Are Mediated by Differential Engagements of Cardiovascular Regulatory Mechanisms in Brain.

Infliximab abrogates cadmium-induced testicular damage and spermiotoxicity via enhancement of steroidogenesis and suppression of inflammation and apoptosis mediators.

Two novel CYP3A isoforms in marine mussel Mytilus coruscus: Identification and response to cadmium and benzo[a]pyrene.

Pharmaceuticals

Single and mixture toxicity of four pharmaceuticals of environmental concern to aquatic organisms, including a behavioral assessment.

Microplastics/Nanoparticles

First report on the mutagenicity and cytotoxicity of Zno nanoparticles in reptiles.

The mechanism-based toxicity screening of particles with use in the food and nutrition sector via the ToxTracker reporter system.

Air Pollution

Developmental programming of obesity by maternal exposure to concentrated ambient PM2.5 is maternally transmitted into the third generation in a mouse model.

Effects of first-generation in utero exposure to diesel engine exhaust on second-generation placental function, fatty acid profiles and foetal metabolism in rabbits: preliminary results.

Wildlife/Environment/Exposure Studies

Multiple Chemicals

Quantification of 16 urinary biomarkers of exposure to flame retardants, plasticizers, and organophosphate insecticides for biomonitoring studies.

Higher health risk resulted from dermal exposure to PCBs than HFRs and the influence of haze.

Firefighters’ and instructors’ absorption of PAHs and benzene during training exercises.

BPA/Phenols

Unexpectedly high concentrations of 2,4-di-tert-butylphenol in human urine.

Persistent Organic Pollutants

Arctic cleansing diet: Sex-specific variation in the rapid elimination of contaminants by the world’s champion migrant, the Arctic tern.

Perfluoroalkyl Substances

Factors affecting spatial and temporal patterns in perfluoroalkyl acid (PFAA) concentrations in migratory aquatic species: a case study of an exploited crustacean.

Flame Retardants

Polybrominated diphenyl ethers and novel brominated flame retardants in human milk from the general population in Beijing, China: Occurrence, temporal trends, nursing infants’ exposure and risk assessment.

The occurrence of polybrominated diphenyl ether (PBDE) contamination in soil, water/sediment, and air.

Pesticides

Occurrence of pesticides in Dutch drinking water sources.

Arsenic/Metals

An Analytical Survey of Trace Heavy Elements in Insecticides.

Cadmium in groundwater – A synopsis based on a large hydrogeochemical data set.

Preliminary study of cellular metal accumulation in two Antarctic marine microalgae – implications for mixture interactivity and dietary risk.

Microplastics

Emission of primary microplastics in mainland China: Invisible but not negligible.

A systematic study of the microplastic burden in freshwater fishes of south-western Germany – Are we searching at the right scale?

Miscellaneous

Landfill leachates and wastewater of maritime origin as possible sources of endocrine disruptors in municipal wastewater.

Environmental and biological monitoring of benzene, toluene, ethylbenzene, and xylene (BTEX) exposure in residents living near gas stations.

The impact of environmental regulation on environmental pollution in China: an empirical study based on the synergistic effect of industrial agglomeration.

This list is not meant to be exhaustive, and generally does not include studies on detection, remediation, or treatment of EDCs. Note that journal publication dates may be different than dates added to PubMed. Compiled by Sarah Howard, Diabetes and Environment Program and HEEDS at Commonweal.