New EDC articles: June 19 – 25, 2019

A summary of articles on endocrine disrupting chemicals (EDCs) added to PubMed this week.

Contents: Interesting Research of the Week, Regulations/Policy, Reviews, Human Health Studies, Laboratory Studies, and Wildlife/Environment/Exposure Studies.

Interesting Research of the Week

The Mouse Mammary Gland: a Tool to Inform Adolescents About Environmental Causes of Breast Cancer.

Reduction of hazardous chemicals in Swedish preschool dust through article substitution actions.

Regulations/Policy

Development of an oral reference dose for the perfluorinated compound GenX.

Unlocking the potential of in silico chemical safety assessment – A report on a cross-sector symposium on current opportunities and future challenges.

Testing developmental toxicity in a second species: are the differences due to species or replication error?

Scientists call for US EPA to reconvene expert panel on particulate matter pollution.

Reviews

Editorial: Nutritional and Environmental Modulation of the Endocrine System: Effects on Metabolism and Growth. [see the full Research Topic here]

Role of Physiologically Based Kinetic modelling in addressing environmental chemical mixtures – A review.

Potential roles of nuclear receptors in mediating neurodevelopmental toxicity of known endocrine-disrupting chemicals in ascidian embryos.

NLRP inflammasome as a key role player in the pathogenesis of environmental toxicants. [re autoimmunity]

Occurrence and Distribution of Organic and Inorganic Pollutants in Groundwater. [pesticides, metals, contaminants of emerging concern, etc.]

BPA/Phenols/Phthalates

Occurrence, fate and toxic effects of the industrial endocrine disrupter, nonylphenol, on plants – A review.

Dioxin

Multigenerational and Transgenerational Effects of Dioxins.

Flame Retardants

A Review of a Class of Emerging Contaminants: The Classification, Distribution, Intensity of Consumption, Synthesis Routes, Environmental Effects and Expectation of Pollution Abatement to Organophosphate Flame Retardants (OPFRs).

Pesticides

Pesticides and the perils of synecdoche in the history of science and environmental history.

Pharmaceuticals

Emerging investigator series: towards a framework for establishing the impacts of pharmaceuticals in wastewater irrigation systems on agro-ecosystems and human health.

Micro/Nano Plastics

Nanoparticle translocation and multi-organ toxicity: A particularly small problem.

Towards the Development and Application of an Environmental Risk Assessment Framework for Microplastic.

Human Health Studies

BPA/Phenols/Phthalates

Bisphenol A and phthalate levels in adolescents with polycystic ovary syndrome.

Prenatal phthalate exposure in relation to gestational age and preterm birth in a prospective cohort study.

Urinary concentrations of environmental phenols and their associations with breast cancer incidence and mortality following breast cancer.

A benchmark dose study of prenatal exposure to di(2-ethylhexyl) phthalate and behavioral problems in children.

Persistent Organic Pollutants

Joint Analysis of Metabolite Markers of Fish Intake and Persistent Organic Pollutants in Relation to Type 2 Diabetes Risk in Swedish Adults.

Serum concentrations and detection rates of selected organochlorine pesticides in a sample of Greek school-aged children with neurodevelopmental disorders.

Perfluoroalkyl Substances

Early life exposures to perfluoroalkyl substances in relation to adipokine hormone levels at birth and during childhood.

Metabolomics of childhood exposure to perfluoroalkyl substances: a cross-sectional study.

Perfluoroalkyl and polyfluoroalkyl substances and fetal thyroid hormone levels in umbilical cord blood among newborns by prelabor caesarean delivery.

Pesticides

Association Between Organic Food Consumption and Breast Cancer Risk: Findings from the Sister Study (P18-038-19).

Temporal variability in urinary pesticide concentrations in repeated-spot and first-morning-void samples and its association with oxidative stress in healthy individuals.

Maternal urinary concentrations of pyrethroid and chlorpyrifos metabolites and attention deficit hyperactivity disorder (ADHD) symptoms in 2-4-year-old children from the Odense Child Cohort.

Arsenic/Metals

Autism Spectrum Disorders: The Association with Inherited Metabolic Disorders and Some Trace Elements. A Retrospective Study.

Associations between blood lead, cadmium, and mercury levels with hyperuricemia in the Korean general population: A retrospective analysis of population-based nationally representative data.

A Prospective Study of Toenail Trace Element Levels and Risk of Skin Cancer.

Effects of Lead, Mercury, and Cadmium Co-exposure on Children’s Pulmonary Function.

Low to Moderate Arsenic Exposure May Not Increase the Risk of Incident Hypertension (P18-011-19).

Association of Urinary Cadmium with Cancer Mortality Is Influenced by Zinc Intake in Follow-up Study of NHANES 1988-1994 and 1999-2004 (P18-026-19).

Is prenatal arsenic exposure associated with salivary cortisol in infants in Arica, Chile? An exploratory cohort study.

PAHs/Air Pollution

Endocrine disruption and commensal bacteria alteration associated with gaseous and soil PAH contamination among daycare children.

Ambient Air Pollution Exposure and Fecundability in Women Undergoing In Vitro Fertilization.

Prenatal ambient air pollution exposure and SOD2 promoter methylation in maternal and cord blood.

Association between Exposure to Air Pollution and Hippocampal Volume in Adults in the UK Biobank.

Airborne mammary carcinogens and breast cancer risk in the Sister Study.

Neonatal blood pressure in association with prenatal air pollution exposure, traffic, and land use indicators: An ENVIRONAGE birth cohort study.

Associations of gestational diabetes mellitus with residential air pollution exposure in a large Southern California pregnancy cohort.

Prenatal air pollution and childhood IQ: Preliminary evidence of effect modification by folate.

Miscellaneous

ETIOSARC study : environmental aetiology of sarcomas from a French prospective multicentric population-based case-control study-study protocol.

Laboratory Studies

BPA/Phenols

Epigenetic effects of in utero bisphenol A administration: Diabetogenic and atherogenic changes in mice offspring.

Estrogenic Compounds or Adiponectin Inhibit Cyclic AMP Response to Human Luteinizing Hormone in Mouse Leydig Tumor Cells.

Effects of quercetin on bisphenol A-induced mitochondrial toxicity in rat liver.

Transcriptomic points-of-departure from short-term exposure studies are protective of chronic effects for fish exposed to estrogenic chemicals.

The effect of bisphenol a exposure onto endothelial and decidualized stromal cells on regulation of the invasion ability of trophoblastic spheroids in in vitro co-culture model.

Bisphenol A-induced apoptosis, oxidative stress and DNA damage in cultured rhesus monkey embryo renal epithelial Marc-145 cells.

Phthalates

Prenatal and ancestral exposure to di(2-ethylhexyl) phthalate alters gene expression and DNA methylation in mouse ovaries.

Benzyl butyl phthalate (BBP) triggers the migration and invasion of hemangioma cells via upregulation of Zeb1.

The interference of DEHP in precocious puberty of females mediated by the hypothalamic IGF-1/PI3K/Akt/mTOR signaling pathway.

Hepatic and renal tissue damage in Balb/c mice exposed to diisodecyl phthalate: The role of oxidative stress pathways.

Retinol binding protein 4 mediates MEHP-induced glucometabolic abnormalities in HepG2 cells.

Dietary diisononylphthalate contamination induces hepatic stress: a multidisciplinary investigation in gilthead seabream (Sparus aurata) liver.

DEHP Nanodroplets Leached from Polyvinyl Chloride IV Bags Promote Aggregation of IVIG and Activate Complement in Human Serum.

Persistent Organic Pollutants

Aryl hydrocarbon receptor activity of polyhalogenated carbazoles and the molecular mechanism.

2,3,7,8-Tetrachlorodibenzo-p–dioxin promotes injury-induced vascular neointima formation in mice.

Temporal changes in the transcriptomic profile of granulosa cells of pigs treated with 2,3,7,8-tetrachlorodibenzo-p–dioxin.

2,3,7,8-Tetrachlorodibenzo-p-dioxin Promotes Proliferation of Astrocyte Cells via the Akt/STAT3/Cyclin D1 Pathway.

A Quantitative HILIC-MS/MS Assay of the Metabolic Response of Huh-7 Cells Exposed to 2,3,7,8-Tetrachlorodibenzo-p–Dioxin.

In vitro assessment of effects of persistent organic pollutants on the transactivation of estrogen receptor α and β (ERα and ERβ) from the Baikal seal (Pusa sibirica).

Flame Retardants

Sub-lethal Doses of Polybrominated Diphenyl Ethers, in Vitro, Promote Oxidative Stress and Modulate Molecular Markers Related to Cell Cycle, Antioxidant Balance and Cellular Energy Management.

Organophosphate flame retardants (OPFRs) induce genotoxicity in vivo: A survey on apoptosis, DNA methylation, DNA oxidative damage, liver metabolites, and transcriptomics.

Pesticides

An intact insect embryo for developmental neurotoxicity testing of directed axonal elongation.

Protective Effect of Alpha-Tocopherol in Deltamethrin Induced Immunotoxicity.

Paraquat Preferentially Induces Apoptosis of Late Stage Effector Lymphocyte and Impairs Memory Immune Response in Mice.

How Glyphosate Impairs Liver Condition in the Field Lizard Podarcis siculus (Rafinesque-Schmaltz, 1810): Histological and Molecular Evidence.

Maternal glyphosate-based herbicide exposure alters antioxidant-related genes in the brain and serum metabolites of male rat offspring.

Effect of organophosphorus pesticides in juveniles of Litopenaeus vannamei: alteration of glycogen, triglycerides, and proteins.

Roundup® confers cytotoxicity through DNA damage and Mitochondria-Associated apoptosis induction.

Evaluation of the cytotoxic effects of glyphosate herbicides in human liver, lung, and nerve.

Arsenic/Metals

Selenium protection against mercury neurotoxicity: Modulation of apoptosis and autophagy in the anterior pituitary.

High-throughput assessment of toxic effects of metal mixtures of cadmium(Cd), lead(Pb), and manganese(Mn) in nematode Caenorhabditis elegans.

Organotins

Genotoxic Effects of Tributyltin and Triphenyltin Isothiocyanates, Cognate RXR Ligands: Comparison in Human Breast Carcinoma MCF 7 and MDA-MB-231 Cells.

Pharmaceuticals

Environmentally relevant concentrations of methamphetamine and sertraline modify the behavior and life history traits of an aquatic invertebrate.

Microplastics

Leaching of endocrine disrupting chemicals from marine microplastics and mesoplastics under common life stress conditions.

Mixtures

Insights Into Cetacean Immunology: Do Ecological and Biological Factors Make the Difference?

Miscellaneous

Impact of Gold Nanoparticles on Testosterone Metabolism in Human Liver Microsomes.

The potential immunotoxicity of fine particulate matter based on SD rat spleen.

A critical role for estrogen signaling in penis development.

Wildlife/Environment/Exposure Studies

BPA/Phenols

Exposición fetal a bisfenol A: Presencia de bisfenol A en orina de mujeres gestantes asistidas en un hospital de la Ciudad de Buenos Aires. Año 2013.

Phthalates

Exposure to Mixed Phthalates in Czech Preschool and School Children.

Persistent Organic Pollutants

Background levels of dioxin-like polychlorinated biphenyls (dlPCBs), polychlorinated, polybrominated and mixed halogenated dibenzo-p-dioxins and dibenzofurans (PCDD/Fs, PBDD/Fs & PXDD/Fs) in sera of pregnant women in Accra, Ghana.

Indicator PCBs in farmed and wild fish in Greece – Risk assessment for the Greek population.

Perfluoroalkyl Substances

Previously unidentified sources of perfluoroalkyl and polyfluoroalkyl substances from building materials and industrial fabrics.

Dietary Characteristics and Exposure to Per- and Polyfluoroalkyl Substances Among Pre-diabetic Adults in Diabetes Prevention Program (OR17-06-19).

Global transport of perfluoroalkyl acids via sea spray aerosol.

Flame Retardants

A comprehensive risk assessment of human inhalation exposure to atmospheric halogenated flame retardants and organophosphate esters in an urban zone.

Short-term variability in levels of urinary phosphate flame retardant metabolites in adults and children from an e-waste recycling site.

Halogenated flame retardants in the sediments of the Chinese Yellow Sea and East China Sea.

Polybrominated diphenyl ethers and alternative halogenated flame retardants in mollusks from the Chinese Bohai Sea: Levels and interspecific differences.

Pesticides

Physiologically based kinetic modelling-facilitated reverse dosimetry to predict in vivo red blood cell acetylcholinesterase inhibition following exposure to chlorpyrifos in the Caucasian and Chinese population.

Risk Assessment for Pesticide Mixtures On Aquatic Ecosystems in China: A Proposed Framework.

The environmental condition of an estuarine ecosystem disturbed by pesticides.

Pesticide metabolite concentrations in Queensland pre-schoolers – Exposure trends related to age and sex using urinary biomarkers.

Arsenic/Metals

Fetal exposure to mercury and lead from intrauterine blood transfusions.

Exposure to mercury among 9-year-old Spanish children: Associated factors and trend throughout childhood.

Infant Formula: An Analysis of the Contents of Plant-Based vs. Whey-Based Formulas (P11-056-19).

From Mexico to the Beagle Channel: A review of metal and metalloid pollution studies on wildlife species in Latin America.

Metals in wild fish from Gaotang Lake in the area of coal mining, China: assessment of the risk to human health.

Arsenic Toxicity: An Arsenic-Hyperaccumulating Fern Uses a Bacterial-like Tolerance Mechanism.

Determining additional risk of carcinogenicity and non-carcinogenicity of heavy metals (lead and arsenic) in raw and as-consumed samples of imported rice in Tehran, Iran.

Lead and Other Trace Elements in Danish Birds of Prey.

Assessment of health risks associated with potentially toxic element contamination of soil by end-of-life ship dismantling in Bangladesh.

Lead, cadmium and arsenic exposure of schoolchildren of northwest Argentina from a risk assessment study.

Food Intake and Blood Levels of Mercury, Lead, and Cadmium Among Healthy Reproductive Aged Women (P18-024-19).

Biomarkers of Heavy Metal Exposure in Women of Reproductive Age in Southern India (P24-054-19).

Effect of Vitamin D Supplementation During Pregnancy on Blood Concentrations of Toxic Metals (P24-063-19).

High Mercury Levels in the Indigenous Population of the Yaigojé Apaporis National Natural Park, Colombian Amazon.

Blood plasma levels of heavy metals and trace elements in white sharks (Carcharodon carcharias) and potential health consequences.

Pharmaceuticals

Spatial and seasonal variations of antibiotics in river waters in the Haihe River Catchment in China and ecotoxicological risk assessment.

Assessing the trend of diabetes mellitus by analyzing metformin as a biomarker in wastewater.

Microplastics

Sources, distribution and fate of microfibres on the Great Barrier Reef, Australia.

Microplastics as a threat to coral reef environments: Detection of phthalate esters in neuston and scleractinian corals from the Faafu Atoll, Maldives.

Miscellaneous

The Search for Environmental Justice: The Story of North Birmingham.

Spatiotemporal evolvement and factors influencing natural and synthetic EDCs and the microbial community at different groundwater depths in the Chaobai watershed: A long-term field study on a river receiving reclaimed water.

Effect-based environmental monitoring for thyroid disruption in Swedish amphibian tadpoles.

This list is not meant to be exhaustive, and generally does not include studies on detection, remediation, or treatment of EDCs. Note that journal publication dates may be different than dates added to PubMed. Compiled by Sarah Howard, Diabetes and Environment Program and HEEDS at Commonweal.