New EDC articles, June 12 – 18, 2019

A summary of articles on endocrine disrupting chemicals (EDCs) added to PubMed this week.

Contents: Interesting Research of the Week, Regulations/Policy, Reviews, Human Health Studies, Laboratory Studies, and Wildlife/Environment/Exposure Studies.

Interesting Research of the Week

The concept of essential use for determining when uses of PFASs can be phased out. Also see the article in Science Daily,

Cutting potentially harmful chemicals like PFAS from consumer goods

Sperm epimutation biomarkers of obesity and pathologies following DDT induced epigenetic transgenerational inheritance of disease.

Using phenome-wide association studies to examine the effect of environmental exposures on human health.

Regulations/Policy

Hexabromocyclododecane (HBCD): A case study applying tiered testing for human health risk assessment.

Genetic toxicology in silico protocol.

The inhibition of adipogenesis via an in vitro assay can reduce animal use by more precisely estimating the starting dose for the acute toxic class method.

CLARITY-BPA Core Study: Analysis for non-monotonic dose-responses and biological relevance.

Reviews

Proposed Key Characteristics of Male Reproductive Toxicants as an Approach for Organizing and Evaluating Mechanistic Evidence in Human Health Hazard Assessments.

Toxicology and Environmental Characteristics of Emerging Pollutants.

The Exposome in Atopic Dermatitis.

BPA/Phenols/Phthalates

A Scoping Review of the Health and Toxicological Activity of Bisphenol A (BPA) Structural Analogues and Functional Alternatives.

Phthalate exposure and metabolic effects: a systematic review of the human epidemiological evidence.

Bisphenol A in dental materials – existence, leakage and biological effects.

Parabens/Triclosan

Paraben Toxicology.

Triclosan: An Update on Biochemical and Molecular Mechanisms.

Pesticides

Neurotoxicity of pesticides.

Air Pollution

Impact of Coal-fired Power Plant Emissions on Children’s Health: A Systematic Review of the Epidemiological Literature.

Human Health Studies

Persistent Organic Pollutants

Exposure to polychlorinated biphenyls and organochlorine pesticides and risk of dementia, Alzheimer’s disease and cognitive decline in an older population: a prospective analysis from the Canadian Study of Health and Aging.

Exposure to polybrominated biphenyl and stochastic epigenetic mutations: application of a novel epigenetic approach to environmental exposure in the Michigan polybrominated biphenyl registry.

Polychlorinated biphenyl serum levels, thyroid hormones and endocrine and metabolic diseases in people living in a highly polluted area in North Italy: A population-based study.

Perfluoroalkyl Substances

Physico-chemical properties and gestational diabetes predict transplacental transfer and partitioning of perfluoroalkyl substances. [this is really interesting too]

Prenatal plasma concentrations of Perfluoroalkyl and polyfluoroalkyl substances and neuropsychological development in children at four years of age.

Pesticides

Associations of acetylcholinesterase activity with depression and anxiety symptoms among adolescents growing up near pesticide spray sites.

Arsenic/Metals

Blood heavy metals and brain-derived neurotrophic factor in the first trimester of pregnancy among migrant workers.

PM2.5 metal constituent exposure and stillbirth risk in Harris County, Texas.

Miscellaneous

Three contaminated sites in southern Italy. The Neonatal Environment and Health Outcomes cohort: protocol for a longitudinal birth cohort study.

Laboratory Studies

BPA/Phenols

Transgenerational Bisphenol A causes deficits in social recognition and alters post-synaptic density genes in mice.

Effect of bisphenol F, an analog of bisphenol A, on the reproductive functions of male rats.

Octylphenol and nonylphenol affect decidualization of human endometrial stromal cells.

Bisphenol S alters development of the male mouse mammary gland and sensitizes it to a peripubertal estrogen challenge.

Maternal exposure to bisphenol A during pregnancy interferes testis development of F1 male mice.

Receptor-binding affinities of bisphenol A and its next-generation analogs for human nuclear receptors.

Genotoxic activity of bisphenol A and its analogues bisphenol S, bisphenol F and bisphenol AF and their mixtures in human hepatocellular carcinoma (HepG2) cells.

Phthalates

Exposure to an environmentally relevant phthalate mixture during prostate development induces microRNA upregulation and transcriptome modulation in rats.

Persistent Organic Pollutants

Altered Gene Expression in Dioxin-Like and Non-Dioxin-Like PCB Exposed Peripheral Blood Mononuclear Cells.

Effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) on the differentiation of embryonic stem cells towards pancreatic lineage and pancreatic beta cell function.

Role of epigenetic regulation of Igf2 and H19 in 2,3,7,8-Tetrachlorobenzo-p-dioxin (TCDD)-induced ovarian toxicity in offspring rats.

Pectin reduces environmental pollutant-induced obesity in mice through regulating gut microbiota: A case study of p,p’-DDE.

Targeted metabolome analysis of the dog brain exposed to PCBs suggests inhibition of oxidative phosphorylation by hydroxylated PCBs.

Perfluoroalkyl Substances

Developmental exposure to perfluorooctane sulfonate (PFOS) and perfluorooctanoic acid (PFOA) selectively decreases brain dopamine levels in northern leopard frogs.

Flame Retardants

Bioconcentration, biotransformation, and thyroid endocrine disruption of decabromodiphenyl ethane (DBDPE), a novel brominated flame retardant, in zebrafish larvae.

Study of BDE-47 induced Parkinson’s disease-like metabolic changes in C57BL/6 mice by integrated metabolomic, lipidomic and proteomic analysis.

Diastereoisomer-specific neurotoxicity of hexabromocyclododecane in human SH-SY5Y neuroblastoma cells.

Pesticides

Cardiotoxicity in African clawed frog (Xenopus laevis) sub-chronically exposed to environmentally relevant atrazine concentrations: Implications for species survival.

Identification of miRNA-7 as a regulator of brain-derived neurotrophic factor/α-synuclein axis in atrazine-induced Parkinson’s disease by peripheral blood and brain microRNA profiling.

The Effects of Maternal Atrazine Exposure and Swimming Training on Spatial Learning Memory and Hippocampal Morphology in Offspring Male Rats via PSD95/NR2B Signaling Pathway.

Are Oxidative Stress Biomarkers Sensitive to Environmental Concentrations of Chlorpyrifos Exposed to the Freshwater Crab, Zilchiopsis collastinensis (Decapoda; Trichodactylidae)?

Biopesticide spinosad induces transcriptional alterations in genes associated with energy production in honey bees (Apis mellifera) at sublethal concentrations.

Effects of atrazine on life parameters, oxidative stress, and ecdysteroid biosynthetic pathway in the marine copepod Tigriopus japonicus.

Ecological toxicity reduction of dinotefuran to honeybee: New perspective from an enantiomeric level.

Development of scleral ossicles in Podocnemis expansa (Testudines: Podocnemididae) embryos exposed to atrazine.

Glyphosate- and Fipronil-Based Agrochemicals and Their Mixtures Change Zebrafish Behavior.

Inflammatory Effects of Subacute Exposure of Roundup in Rat Liver and Adipose Tissue.

Arsenic/Metals

Combined effects of arsenic exposure and diabetes on male reproductive functions.

Mitigative effects of natural and model dissolved organic matter with different functionalities on the toxicity of methylmercury in embryonic zebrafish.

Effects of Methylmercury and Theaflavin Digallate on Adipokines in Mature 3T3-L1 Adipocytes.

Methylmercury, cadmium and arsenic(III)-induced toxicity, oxidative stress and apoptosis in Pacific red snapper leukocytes.

Mixture effect of arsenic and fluoride at environmentally relevant concentrations in zebrafish (Danio rerio) liver: Expression pattern of Nrf2 and related xenobiotic metabolizing enzymes.

Pharmaceuticals

Behaviour and cardiac response to stress in signal crayfish exposed to environmental concentrations of tramadol.

Screening

Gonadosomatic index as a confounding variable in fish-based screening assays for the detection of anti-estrogens and nonaromatizable androgens.

Development of a Zebrafish S1500+ Sentinel Gene Set for High-Throughput Transcriptomics.

Comparative analysis of Rapid Equilibrium Dialysis (RED) and solid phase micro-extraction (SPME) methods for In Vitro-In Vivo extrapolation of environmental chemicals.

Development of a neurotoxicity assay that is tuned to detect mitochondrial toxicants.

Mixtures

Mixture toxicity effects and uptake of titanium dioxide (TiO2) nanoparticles and 3,3′,4,4′-tetrachlorobiphenyl (PCB77) in juvenile brown trout following co-exposure via the diet.

Preconceptional, Gestational, and Lactational Exposure to an Unconventional Oil and Gas Chemical Mixture Alters Energy Expenditure in Adult Female Mice.

In vitro effects of single and binary mixtures of regulated mycotoxins and persistent organochloride pesticides on steroid hormone production in MA-10 Leydig cell line.

Miscellaneous

Biomphalaria alexandrina: a model organism for assessing the endocrine disrupting effect of 17β-estradiol.

Monitoring estrogenic activities of waste and surface waters using a novel in vivo zebrafish embryonic (EASZY) assay: Comparison with in vitro cell-based assays and determination of effect-based trigger values.

Trichloroethylene in drinking water throughout gestation did not produce congenital heart defects in Sprague Dawley rats.

Wildlife/Environment/Exposure Studies

BPA/Phenols

Occurrence of Bisphenol A and its analogues in some foodstuff marketed in Europe.

Comparison of Bisphenol A and Bisphenol S Percutaneous Absorption and Biotransformation.

Trends and disparities in urinary BPA concentrations among U.S. emerging adults.

Phthalates

Phthalate esters (PAEs) in atmospheric particles around a large shallow natural lake (Lake Chaohu, China).

Persistent Organic Pollutants

Ecological Legacy of DDT Archived in Lake Sediments from Eastern Canada.

Characterization of organic contaminants in fjords and bays on the Kenai Peninsula Alaska.

Soil burden by persistent organochlorine compounds in the vicinity of a coal-fired power plant in Croatia: a comparison study with an urban-industrialized area.

Research on pollution prevention and control BAT of PCDD/Fs in secondary copper industry.

Bulk atmospheric deposition of persistent organic pollutants and polycyclic aromatic hydrocarbons in Central Europe.

Summary data of serum concentrations of 32 persistent organic pollutants in young adults in relation to summary scores of persistent organic pollutants.

Efficacy of a school-based intervention to bring awareness about PCB contamination and exposure avoidance in Guánica, Puerto Rico.

Presence of organic halogenated compounds, organophosphorus insecticides and polycyclic aromatic hydrocarbons in meat of different game animal species from an Italian subalpine area.

Perfluoroalkyl Substances/Flame Retardants

Are perfluoroalkyl substances in water and fish from drinking water source the major pathways towards human health risk?

Characteristics and human inhalation exposure of ionic per- and polyfluoroalkyl substances (PFASs) in PM10 of cities around the Bohai Sea: Diurnal variation and effects of heating activity.

Dietary exposure to perfluoroalkyl acids, brominated flame retardants and health risk assessment in the French infant total diet study.

Distribution and diastereoisomeric profiles of hexabromocyclododecanes in air, water, soil, and sediment samples in South Korea: Application of an optimized analytical method.

Brominated flame retardants in animal derived foods in the Netherlands between 2009 and 2014.

Abundances and concentrations of brominated azo dyes detected in indoor dust.

Metabolites of phosphate flame retardants and alternative plasticizers in urine from intensive care patients.

Pesticides

Knowledge and behavior regarding pesticide use: a survey among caregivers of children aged 1-6 years from rural China.

A spatial approach to identify priority areas for pesticide pollution mitigation.

Urinary metabolites of organophosphate and pyrethroid pesticides in children from an Italian cohort (PHIME, Trieste).

Arsenic/Metals

Heavy metals in the glass and enamels of consumer container bottles.

An overview of environmental arsenic issues and exposure risks in Uruguay.

Serum concentration of toxic metals and rare earth elements in children and adolescent. [Romania]

Probabilistic health risk assessment of heavy metals in honey, Manihot esculenta, and Vernonia amygdalina consumed in Enugu State, Nigeria.

Tuna consumption, mercury exposure, and knowledge about mercury exposure risk from tuna consumption in university students.

Mercury and cadmium distribution in yellowfin tuna (Thunnus albacares) from two fishing grounds in the Indian Ocean near Sri Lanka.

Physiological response of Posidonia oceanica to heavy metal pollution along the Tyrrhenian coast.

Environmental Risk Assessment of Metals in the Volcanic Soil of Changbai Mountain.

Potential sources and associated risk assessment of potentially toxic elements in paddy soils of a combined urban and rural area.

Distribution characteristics and influencing factors of heavy metals in scalp hair of Huainan urban residents.

Patterns of mercury and selenium exposure in minnesota common loons.

Temporal trends of mercury differ across three northern white-tailed eagle (Haliaeetus albicilla) subpopulations.

Temporal changes in atmospheric mercury concentrations at a background mountain site downwind of the East Asia continent in 2006-2016.

The determinants of China’s national and regional energy-related mercury emission changes.

Levels of Mercury in Fish-Eating Children, With and Without Amalgam Restoration.

Trace elements accumulation in the Yangtze finless porpoise (Neophocaena asiaeorientalis asiaeorientalis) – A threat to the endangered freshwater cetacean.

Bioaccumulation and potential sources of heavy metal contamination in fish species in River Ganga basin: Possible human health risks evaluation.

Globally temporal transitions of blood lead levels of preschool children across countries of different categories of Human Development Index.

Microplastics

Human Consumption of Microplastics.

Microplastics in coastal areas and seafood: implications for food safety.

Occurrence and risk assessment of microplastics from various toothpastes.

Microplastics in the Coral Reef Systems from Xisha Islands of South China Sea.

The uptake and elimination of polystyrene microplastics by the brine shrimp, Artemia parthenogenetica, and its impact on its feeding behavior and intestinal histology.

Miscellaneous

A baseline assessment of emerging organic contaminants in New Zealand groundwater. [pesticides, pharmaceuticals, personal care products, industrial chemicals, etc.]

Contaminants of emerging concern in freshwater fish from four Spanish Rivers. [EDCs, pharmaceuticals, pesticides, personal care products, flame retardants, etc.]

Suspect, non-target and target screening of emerging pollutants using data independent acquisition: Assessment of a Mediterranean River basin. [pesticides, pharmaceuticals, personal care products]

Chlorinated Paraffins in Car Tires recycled to Rubber Granulates and Playground Tiles.

Family medicine residents’ knowledge of, attitudes toward, and clinical practices related to environmental health: Multi-program survey.

This list is not meant to be exhaustive, and generally does not include studies on detection, remediation, or treatment of EDCs. Note that journal publication dates may be different than dates added to PubMed. Compiled by Sarah Howard, Diabetes and Environment Program and HEEDS at Commonweal.