New EDC articles: May 29 – June 4, 2019

A summary of articles on endocrine disrupting chemicals (EDCs) added to PubMed this week. There’s a ton of good stuff this week!

Contents: Interesting Research of the Week, Regulations/Policy, Reviews, Human Health Studies, Laboratory Studies, and Wildlife/Environment/Exposure Studies.

Interesting Research of the Week

Widespread occurrence of bisphenol A in daily clothes and its high exposure risk in humans.

Phthalates in infant cotton clothing: Occurrence and implications for human exposure.

Regulations/Policy

Building and Applying Quantitative Adverse Outcome Pathway Models for Chemical Hazard and Risk Assessment.

Risky Business? Manufacturer and Retailer Action to Remove Per- and Polyfluorinated Chemicals From Consumer Products.

Reviews

A mechanism for the effect of endocrine disrupting chemicals on placentation.

Environmental monitoring and the developmental origins of health and disease.

Review of the Effects of Perinatal Exposure to Endocrine-Disrupting Chemicals in Animals and Humans.

Mechanisms of Environmental Contributions to Fatty Liver Disease.

A link between environmental pollution and civilization disorders: a mini review.

The evolutionary road to invertebrate thyroid hormone signaling: Perspectives for endocrine disruption processes.

Review of the Literature on Current Changes in the Timing of Pubertal Development and the Incomplete Forms of Early Puberty.

Etiologic links between environmental and lifestyle factors and Essential tremor.

Food toxicology: quantitative analysis of the research field literature.

30th anniversary for the Developmental Origins of Endocrinology. [special issue of J Endocrinol on DOHaD]

Possible role of extracellular vesicles in exogenous chemical exposure-associated health concern.

Contaminant and Environmental Influences on Thyroid Hormone Action in Amphibian Metamorphosis.

A review of threats to groundwater quality in the anthropocene.

BPA/Phenols/Phthalates

Occurrence, toxicity and endocrine disrupting potential of Bisphenol-B and Bisphenol-F: A mini-review.

A strategy to validate a selection of human effect biomarkers using adverse outcome pathways: Proof of concept for phthalates and reproductive effects.

Persistent Organic Pollutants

Are the civilization diseases the result of organohalogen environmental pollution?

Prenatal exposure to PCBs and neurological and sexual/pubertal development from birth to adolescence.

Metals

Mercury exposure and its effects on fertility and pregnancy outcomes.

Cadmium toxicity: effects on human reproduction and fertility.

Lead-based paints and children’s PVC toys are potential sources of domestic lead poisoning – A review.

Pesticides

Analysis of scientific production on glyphosate: An example of politicization of science.

The agro-enabled urban revolution, pesticides, politics, and popular culture: a case study of land use, birds, and insecticides in the USA. [by Syngenta]

Perspective: Are honeybees suitable surrogates for use in pesticide risk assessment for non-Apis bees? [Syngenta again]

Effects of herbicide on non-target microorganisms: Towards a new class of biomarkers?

Alternatives to neonicotinoids.

Microplastics

Adverse outcome pathways potentially related to hazard identification of microplastics based on toxicity mechanisms.

Environmentally accurate microplastic levels and their absence from exposure studies on aquatic taxa.

Pharmaceuticals

An overview of cephalosporin antibiotics as emerging contaminants: a serious environmental concern.

Miscellaneous

Hazard and mode of action of disinfection by-products (DBPs) in water for human consumption: Evidences and research priorities.

Human Health Studies

Phthalates

Seminal plasma metabolome in relation to semen quality and urinary phthalate metabolites among Chinese adult men.

Changes in insulin resistance mediate the associations between phthalate exposure and metabolic syndrome.

Persistent Organic Pollutants

Persistent organic pollutants and the incidence of type 2 diabetes in the CARLA and KORA cohort studies.

Human prenatal exposure to polychlorinated biphenyls (PCBs) and risk behaviors in adolescence.

Relative Effect Potency Estimates for Dioxin-like Compounds in Pregnant Women with Gestational Diabetes Mellitus and Blood Glucose Outcomes Based on a Nested Case-control Study.

Perfluoroalkyl Substances

Association of perfluoroalkyl substances exposure with cardiometabolic traits in an island population of the eastern Adriatic coast of Croatia.

Prenatal perfluorooctanoic acid exposure is associated with early onset atopic dermatitis in 5-year-old children.

Longitudinal analysis reveals early-pregnancy associations between perfluoroalkyl sulfonates and thyroid hormone status in a Canadian prospective birth cohort.

Per- and polyfluoroalkyl substances and blood lipid levels in pre-diabetic adults-longitudinal analysis of the diabetes prevention program outcomes study.

Pesticides

Association of Organophosphate Pesticide Exposure and a Marker of Asthma Morbidity in an Agricultural Community.

Assessment of genotoxicity and cholinesterase activity among women workers occupationally exposed to pesticides in tea garden.

Blood pressure after a heightened pesticide spray period among children living in agricultural communities in Ecuador.

Arsenic/Metals

Associations between multiple serum metal exposures and low birth weight infants in Chinese pregnant women: A nested case-control study.

The relationships of blood lead level, body mass index, and osteoarthritis in postmenopausal women.

Association of Arsenic Exposure with Whole Blood DNA Methylation: An Epigenome-Wide Study of Bangladeshi Adults.

Serum heavy metal levels are associated with asthma, allergic rhinitis, atopic dermatitis, allergic multimorbidity, and airflow obstruction.

Long-term exposure to atmospheric metals assessed by mosses and mortality in France.

Urinary arsenic concentration, airway inflammation, and lung function in the U.S. adult population.

Rice Consumption and Subclinical Lung Disease in US Adults: Observational Evidence from the Multi-Ethnic Study of Atherosclerosis.

Endocrine-disrupting metals in ambient air and female breast cancer incidence in US.

Exploring the potential carcinogenic role of arsenic in gallbladder cancer.

Serum cadmium and lead, current wheeze, and lung function in a nationwide study of adults in the United States.

Plasma metals and cardiovascular disease in patients with type 2 diabetes.

Association of prenatal exposure to arsenic with newborn telomere length: Results from a birth cohort study.

Miscellaneous

Associations between semen phytoestrogens concentrations and semen quality in Chinese men.

Methodological approaches to the study of cancer risk in the vicinity of pollution sources: the experience of a population-based case-control study of childhood cancer.

Laboratory Studies

BPA/Phenols

CLARITY-BPA: Bisphenol A or Propylthiouracil on Thyroid Function and Effects in the Developing Male and Female Rat Brain.

A pilot study on polycystic ovarian syndrome caused by neonatal exposure to tributyltin and bisphenol A in rats.

Insights into the activation mechanism of human estrogen-related receptor γ by environmental endocrine disruptors.

Cardiogenesis impairment promoted by bisphenol A exposure is successfully counteracted by epigallocatechin gallate.

Prenatal exposure to bisphenol A, E and S induces transgenerational effects on female reproductive functions in mice.

Neonatal Bisphenol A Exposure Affects the IgM Humoral Immune Response to 4T1 Breast Carcinoma Cells in Mice.

Bisphenol A promotes the invasive and metastatic potential of ductal carcinoma in situ and pro-tumorigenic polarization of macrophages.

4-Nonylphenol-enhanced EZH2 and RNF2 expression, H3K27me3 and H2AK119ub1 marks resulting in silencing of p21CDKN1A in vitro.

Efficiency of naringin against reproductive toxicity and testicular damages induced by bisphenol A in rats.

Investigation of the effect for bisphenol A on oxidative stress in human hepatocytes and its interaction with catalase.

Gonadal, body color, and genotoxic alterations in Lithobates catesbeianus tadpoles exposed to nonylphenol.

Exposure to environmental toxicants reduces global N6-methyladenosine RNA methylation and alters expression of RNA methylation modulator genes. [BPA, vinclozolin, particulate matter, arsenic]

Phthalates

Longitudinal Metabolic Impacts of Perinatal Exposure to Phthalates and Phthalate Mixtures in Mice.

Simultaneous determination of diethyl phthalate and its major metabolite, monoethyl phthalate, in rat plasma, urine, and various tissues collected from a toxicokinetic study by ultrahigh performance liquid chromatography-tandem mass spectrometry.

Toxicological assessment of phthalates and their alternatives using human keratinocytes.

Study on the Metabolism Toxicity, Susceptibility and Mechanism of Di-(2-ethylhexyl) Phthalate on Rat Liver BRL Cells with Insulin Resistance in vitro.

Dibutyl phthalate exposure disrupts the progression of meiotic prophase I by interfering with homologous recombination in fetal mouse oocytes.

Persistent Organic Pollutants

Effect of Subtoxic DDT Exposure on Glucose Uptake and Insulin Signaling in Rat L6 Myoblast-Derived Myotubes.

Interactions of Dichlorodiphenyltrichloroethane (DDT) and Dichlorodiphenyldichloroethylene (DDE) with Skeletal Muscle Ryanodine Receptor Type 1.

Binding and activity of sulfated metabolites of lower-chlorinated polychlorinated biphenyls towards thyroid hormone receptor alpha.

Perfluoroalkyl Substances

The effect of environmentally relevant emerging per- and polyfluoroalkyl substances on the growth and antioxidant response in marine Chlorella sp.

Bioaccumulation in the gut and liver causes gut barrier dysfunction and hepatic metabolism disorder in mice after exposure to low doses of OBS. [OBS is “a new kind of perfluoroalkyl and polyfluoroalkyl compound”]

Flame Retardants

Toxicity of Flame Retardant Isopropylated Triphenyl Phosphate: Liver, Adrenal, and Metabolic Effects.

PBDEs and Gut Microbiome Modulate Metabolic Syndrome-Related Aqueous Metabolites in Mice.

Embryoid body-based RNA-seq analyses reveal a potential TBBPA multifaceted developmental toxicity.

Inhibition of progesterone biosynthesis induced by deca-brominated diphenyl ether (BDE-209) in mouse Leydig tumor cell (MLTC-1).

Binding and activity of polybrominated diphenyl ether sulfates to thyroid hormone transport proteins and nuclear receptors.

Neurodevelopmental toxicity assessments of alkyl phenanthrene and Dechlorane Plus co-exposure in zebrafish.

Pesticides

Effects of chlorpyrifos on cell death and cellular phenotypic specification of human neural stem cells.

Effect of acute exposure of triazophos on histological structure and apoptosis of the brain and liver of zebrafish (Danio rerio).

Acute in vitro exposure to environmentally relevant atrazine levels perturbs bovine preimplantation embryo metabolism and cell number.

Sub-lethal effects of the triazole fungicide propiconazole on zebrafish (Danio rerio) development, oxidative respiration, and larval locomotor activity.

Paraquat exposure delays stem/progenitor Leydig cell regeneration in the adult rat testis.

Pubertal exposure to tebuconazole increases testosterone production via inhibiting testicular aromatase activity in rats.

Effects of low glyphosate-based herbicide concentrations on endocrine-related gene expression in the decapoda Macrobrachium potiuna.

Effects of Diethyl Phosphate, a Non-Specific Metabolite of Organophosphorus Pesticides, on Serum Lipid, Hormones, Inflammation, and Gut Microbiota.

Toxicity and metabolic fate of the fungicide carbendazim in the typical freshwater diatom Navicula sp.

Endocrine disrupting effects of tebuconazole on different life stages of zebrafish (Danio rerio).

Evaluating the Protective Role of Ascorbic Acid in Malathion-induced Testis Tissue Toxicity of Male Rats.

The role of ghrelin and tumor necrosis factor alpha in diazinon-induced dyslipidemia: insights into energy balance regulation.

Novel mechanism of endocrine disruption by fungicides through binding to the membrane androgen receptor, ZIP9 (SLC39A9), and antagonizing rapid testosterone induction of the intrinsic apoptotic pathway.

Hepatotoxicity of tricyclazole in zebrafish (Danio rerio).

The Effect of Acute Organophosphate Intoxication on Female Rat Hippocampus Cornu Ammonis Region Pyramidal Neuron Numbers, Biochemistry and Morphology.

Garlic and allopurinol attenuate hepatic apoptosis induced by fipronil in male albino rats.

Protective mechanism of Taxifolin for chlorpyrifos neurotoxicity in BV2 cells.

Arsenic/Metals

Zebrafish neurobehavioral phenomics applied as the behavioral warning methods for fingerprinting endocrine disrupting effect by lead exposure at environmentally relevant level.

Thymoquinone attenuates testicular and spermotoxicity following subchronic lead exposure in male rats: Possible mechanisms are involved.

Effect of low-dose tungsten on human thyroid stem/precursor cells and their progeny.

Lead acetate induces apoptosis in Leydig cells by activating PPARγ/caspase-3/PARP pathway.

Arsenic inhibited cholesterol efflux of THP-1 macrophages via ROS-mediated ABCA1 hypermethylation.

Downregulations of placental fatty acid transporters during cadmium-induced fetal growth restriction.

Pharmaceuticals

Parental gemfibrozil exposure impacts zebrafish F1 offspring, but not subsequent generations.

Neonatal exposure to agonists and antagonists of sex steroid receptors induces changes in the expression of oocyte-derived growth factors and their receptors in ovarian follicles in gilts.

Impacts of in vivo and in vitro exposures to tamoxifen: Comparative effects on human cells and marine organisms.

Evaluation of the testis function of mice exposed in utero and during lactation to Pfaffia glomerata (Brazilian ginseng).

Biotoxicity of diclofenac on two larval amphibians: Assessment of development, growth, cardiac function and rhythm, behavior and antioxidant system.

Microplastics

Effects of Nylon Microplastic on Feeding, Lipid Accumulation, and Moulting in a Coldwater Copepod.

Uptake and effects of orally ingested polystyrene microplastic particles in vitro and in vivo.

Polystyrene microplastics ingestion induced behavioral effects to the cladoceran Daphnia magna.

An assessment of the toxicity of polypropylene microplastics in human derived cells.

Impacts of dietary exposure to different sized polystyrene microplastics alone and with sorbed benzo[a]pyrene on biomarkers and whole organism responses in mussels Mytilus galloprovincialis.

Screening

Using the concordance of in vitro and in vivo data to evaluate extrapolation assumptions.

Validation of in vitro methods for human cytochrome P450 enzyme induction: Outcome of a multi-laboratory study.

Mixtures

Evaluation of mixture effects of endocrine active substances in wastewater using CALUX reporter-gene assays.

Miscellaneous

Endocrine disrupting effects in western mosquitofish Gambusia affinis in two rivers impacted by untreated rural domestic wastewaters.

Metabolite tracking to elucidate the effects of environmental pollutants.

Effects of corexit 9500A and Corexit-crude oil mixtures on transcriptomic pathways and developmental toxicity in early life stage mahi-mahi (Coryphaena hippurus).

Sub-chronic palladium nanoparticle effects on the endocrine reproductive system of female Wistar rats: Preliminary data.

Wildlife/Environment/Exposure Studies

BPA/Phenols/Parabens/ Phthalates

Occurrence, behavior and risk assessment of estrogens in surface water and sediments from Hanjiang River, Central China.

Ecological risks of phenolic endocrine disrupting compounds in an urban tropical river.

Simultaneous determination of parabens, bisphenols and alkylphenols in human placenta by ultra-high performance liquid chromatography-tandem mass spectrometry.

Contamination status of bisphenol A and its analogues (bisphenol S, F and B) in foodstuffs and the implications for dietary exposure on adult residents in Zhejiang Province.

Release and migration of cyclic polyester oligomers from bisphenol A non-intent polyester-phenol-coatings into food simulants and infant food – a comprehensive study.

Dietary Predictors of Phthalate and Bisphenol Exposures in Pregnant Women.

Reduction of exposure to plasticizers in stored red blood cell units.

Mothers and children are related, even in exposure to chemicals present in common consumer products.

Persistent Organic Pollutants

A review of organochlorine pesticides and polychlorinated biphenyls in Lebanon: Environmental and human contaminants.

A retrospective investigation into the occurrence and human exposure to polychlorinatednaphthalenes (PCNs), dibenzo-p-dioxins and furans (PCDD/Fs) and PCBs through cod liver products (1972-2017).

PBDEs and PCBs in terrestrial ecosystems of the Victoria Land, Antarctica.

Assessment of PCB contamination, the potential for in situ microbial dechlorination and natural attenuation in an urban watershed at the East Coast of the United States.

Fate of organic micropollutants and their biological effects in a drinking water source treated by a field-scale constructed wetland. [PAHs, PCBs, OCPs, OPPs, phthalates]

Effects of maternal reproductive investment on sex-specific pollutant accumulation in seabirds: a meta-analysis. [PCBs, PFASs, Hg]

Examining the relationships between blubber steroid hormones and persistent organic pollutants in common bottlenose dolphins.

Persistent organic pollutants in typical lake ecosystems.

Legacy and emerging pollutants in marine bivalves from the Galician coast (NW Spain).

Organochlorines in fish from the coastal coral reefs of Weizhou Island, south China sea: Levels, sources, and bioaccumulation.

Accumulation and fate processes of organochlorine pesticides (OCPs) in soil profiles in Mt. Shergyla, Tibetan Plateau: A comparison on different forest types.

Historical and future polychlorinated biphenyl emission trends in Japan.

Bioaccumulation of polycyclic aromatic hydrocarbons (PAHs) in wild marine fish from the coastal waters of the northern South China Sea: Risk assessment for human health.

Perfluoroalkyl Substances

Determinants of per- and polyfluoroalkyl substances (PFAS) in midlife women: Evidence of racial/ethnic and geographic differences in PFAS exposure.

Evidences for replacing legacy per- and polyfluoroalkyl substances with emerging ones in Fen and Wei River basins in central and western China.

Vertical distribution of perfluoroalkyl substances in water columns around the Japan sea and the Mediterranean Sea.

Occurrence and distribution of per- and polyfluoroalkyl substances (PFASs) in the seawater and sediment of the South China sea coastal region.

Prenatal exposure to PFOS and PFOA in a pregnant women cohort of Catalonia, Spain.

Occurrence and tissue distribution of perfluoroalkyl substances (PFASs) in sharks and rays from the eastern Mediterranean Sea.

Human exposure to PFOS and mercury through meat from baltic harbour seals (Phoca vitulina).

Occurrence of perfluoroalkyl substances (PFASs) in a large number of wild and farmed aquatic animals collected in the Netherlands.

Flame Retardants

Occurrence of two novel triazine-based flame retardants in an E-waste recycling area in South China: Implication for human exposure.

Exposure of Canadian electronic waste dismantlers to flame retardants.

Occurrence, distribution and health risk assessment of organophosphate esters in outdoor dust in Nanjing, China: Urban vs. rural areas.

Occurrence, Distribution, and Potential Sources of Organophosphate Esters in Urban and Rural Surface Water in Shanghai, China.

Brominated flame retardants in a computer technical service: Indoor air gas phase, submicron (PM1) and coarse (PM10) particles, associated inhalation exposure, and settled dust.

Occupational exposure to polybrominated diphenyl ethers or decabromodiphenyl ethane during chemical manufacturing: Occurrence and health risk assessment.

Legacy Polybrominated Diphenyl Ethers (PBDEs) Trends in Top Predator Fish of the Laurentian Great Lakes (GL) from 1979 to 2016: Will Concentrations Continue to Decrease?

Contamination and ecological risk of polybrominated diphenyl ethers (PBDEs) in surface sediments of mangrove wetlands: A nationwide study in China.

Bioaccumulation and translocation of tetrabromobisphenol A and hexabromocyclododecanes in mangrove plants from a national nature reserve of Shenzhen City, South China.

PBDEs in cod (Gadus morhua) liver products (1972-2017): Occurrence and human exposure.

Pesticides

Occurrence of Fipronil in residential house dust in the presence and absence of pets: a hint for a comprehensive toxicological assessment.

Pesticides in the typical agricultural groundwater in Songnen plain, northeast China: occurrence, spatial distribution and health risks.

Predicting impacts of chemicals from organisms to ecosystem service delivery: A case study of insecticide impacts on a freshwater lake. [Syngenta yet again]

Occurrence of neonicotinoids and fipronil in estuaries and their potential risks to aquatic invertebrates.

Arsenic/Metals

Fluoride exposure is associated with altered metabolism of arsenic in an adult Mexican population.

Multiple exposure pathways and health risk assessment of heavy metal(loid)s for children living in fourth-tier cities in Hubei Province.

Freshwater neotropical oligochaetes as native test species for the toxicity evaluation of cadmium, mercury and their mixtures.

Ubiquitous Identification of Inorganic Arsenic in a Cohort of Second Trimester Amniotic Fluid in Women with Preterm and Term Births.

Metal Contamination in Seven Tributaries of the Ganga River and Assessment of Human Health Risk from Fish Consumption.

Assessment of heavy metals in the surface sediments and sediment-water interface of Lake Cajititlán, Mexico.

Mercury in Our Food.

Determination of Total Mercury and Methylmercury Concentrations in Commercial Canine Diets.

What is in commercial cat and dog food? The case for mercury and ingredient testing.

Heavy Metals in Suspended Particulate Matter of the Zhujiang River, Southwest China: Contents, Sources, and Health Risks.

Assessments of Metals in Coastal Environments: State of Art.

Quality Indicators and Possible Ecological Risks of Heavy Metals in the Sediments of three Semi-closed East Mediterranean Gulfs.

Cadmium contamination in agricultural soils of China and the impact on food safety.

Dietary Patterns Are Not Consistently Associated with Variability in Blood Lead Concentrations in Pregnant British Women.

Seasonal variation of arsenic and antimony in surface waters of small subarctic lakes impacted by legacy mining pollution near Yellowknife, NT, Canada.

Heavy metals in farmed and wild milkfish (Chanos chanos) and wild mullet (Mugil cephalus) along the coasts of Tanzania and associated health risk for humans and fish.

Municipal solid waste (MSW) incineration fly ash as an important source of heavy metal pollution in China.

Effects of water impoundment and water-level manipulation on the bioaccumulation pattern, trophic transfer and health risk of heavy metals in the food web of Three Gorges Reservoir (China).

Metal pollution in surface sediments from Rodrigo de Freitas Lagoon (Rio de Janeiro, Brazil): Toxic effects on marine organisms.

Evaluation of heavy metals background in the Adriatic Sea sediments of Abruzzo region, Italy.

Pharmaceuticals

Occurrence and potential human health risk of pharmaceutical residues in drinking water from Putrajaya (Malaysia).

Quantification of multi-classes of endocrine-disrupting compounds in estuarine water.

Human pharmaceuticals in three major fish species from the Uruguay River (South America) with different feeding habits.

Psychoactive pharmaceuticals and illicit drugs in coastal waters of North-Western Spain: Environmental exposure and risk assessment.

Microplastics

Occurrence and distribution of microplastics in the surface water and sediment of two typical estuaries in Bohai Bay, China.

Spatiotemporal distribution and annual load of microplastics in the Nakdong River, South Korea.

Miscellaneous

Biomonitoring of zearalenone and its main metabolites in urines of Bangladeshi adults.

Seasonal profiles of atmospheric PAHs in an e-waste dismantling area and their associated health risk considering bioaccessible PAHs in the human lung.

Progress on bringing together raptor collections in Europe for contaminant research and monitoring in relation to chemicals regulation.

Organic micropollutants in the surface riverine sediment along the lower stretch of the transboundary river Ganga: Occurrences, sources and ecological risk assessment.

Effects of environmental pollution on the rDNAomics of Amazonian fish.

Redox and global interconnected proteome changes in mice exposed to complex environmental hazards surrounding Doñana National Park.

This list is not meant to be exhaustive, and generally does not include studies on detection, remediation, or treatment of EDCs. Note that journal publication dates may be different than dates added to PubMed. Compiled by Sarah Howard, Diabetes and Environment Program and HEEDS at Commonweal.