New EDC articles, May 15 – 21, 2019

Post author:HEEDS
Post published:May 21, 2019
Post category:EDC Science Weekly

A summary of articles on endocrine disrupting chemicals (EDCs) added to PubMed this week.

Contents: Regulations/Policy, Reviews, Human Health Studies, Laboratory Studies, and Wildlife/Environment/Exposure Studies.

Regulations/Policy

Challenges in working towards an internal threshold of toxicological concern (iTTC) for use in the safety assessment of cosmetics: Discussions from the Cosmetics Europe iTTC Working Group workshop.

Exposure pattern-specific species sensitivity distributions for the ecological risk assessments of insecticides.

Reviews

The environmental chemicals that change our minds and bodies. Michele La Merrill reviews the book Sicker, Fatter, Poorer by Leo Trasande, in The Lancet Diabetes and Endocrinology.

Prenatal epigenetics diets play protective roles against environmental pollution.

Gut microbiota of aquatic organisms: A key endpoint for ecotoxicological studies.

Metformin as a protective agent against natural or chemical toxicities: a comprehensive review on drug repositioning.

Exosomes as Mediators of Chemical-Induced Toxicity.

Environment, lifestyle, and Parkinson’s disease: Implications for prevention in the next decade.

Understanding Environmental Contaminants’ Direct Effects on Non-alcoholic Fatty Liver Disease Progression.

Alternative ligands for thyroid hormone receptors.

Health risk in road transport workers. Part I. Occupational exposure to chemicals, biomarkers of effect.

Health risk in transport workers. Part II. Dietary compounds as modulators of occupational exposure to chemicals.

The utility of vitellogenin as a biomarker of estrogenic endocrine disrupting chemicals in molluscs.

BPA/Phenols/Phthalates

The Impact of Bisphenol A on Fertility, Reproductive System, and Development: A Review of the Literature.

Systematic review and quality ranking of studies of two phthalate metabolites and anogenital distance, bone health, inflammation, and oxidative stress.

Persistent Organic Pollutants

[Systematic review of the impact of chlordecone on human health in the French West Indies]. [French]

Flame Retardants

Toward fire safety without chemical risk. [Perspective in Science]

Metals/Arsenic

Arsenic (Arsine) Toxicity.

Heavy metals pollution assessment and its associated human health risk evaluation of urban soils from Indian cities: a review.

Human Health Studies

Exposure to environmental pollutants and a marker of early kidney injury in the general population: Results of a nationally representative cross-sectional study based on the Korean National Environmental Health Survey (KoNEHS) 2012-2014. [triclosan, BPA, phthalates, heavy metals, etc.]

BPA/Phenols

Body fluid concentrations of bisphenol A and their association with in vitro fertilization outcomes.

Urinary bisphenol A concentration and glucose homeostasis in non-diabetic adults: a repeated-measures, longitudinal study.

Phthalates

Heterogeneity in childhood body mass trajectories in relation to prenatal phthalate exposure.

Associations of Phthalates and Phthalate Replacements With CRH and Other Hormones Among Pregnant Women in Puerto Rico.

Persistent Organic Pollutants

Neuroimaging signatures of brain plasticity in adults with prenatal exposure to polychlorinated biphenyls: Altered functional connectivity on functional MRI.

The Impact of Agent Orange Exposure on Prostate Cancer Outcomes.

Effect of dioxin-related compounds on oral pigmentation in patients affected by the Yusho incident.

Metabolome Wide Association Study of serum DDT and DDE in Pregnancy and Early Postpartum.

Effects of perinatal dioxin exposure on development of children: a 3-year follow-up study of China cohort.

Selected persistent organic pollutants associated with the risk of primary ovarian insufficiency in women.

Obesity in relation to serum persistent organic pollutant concentrations in CHAMACOS women.

Perfluoroalkyl Substances

Prenatal Exposure to Per- and Polyfluoroalkyl Substances (PFASs) and Association between the Placental Transfer Efficiencies and Dissociation Constant of Serum Proteins-PFAS Complexes.

Pesticides

Associations of prenatal and childhood chlorpyrifos exposure with Neurodevelopment of 3-year-old children.

Arsenic/Metals

Placental Expression of Imprinted Genes, Overall and in Sex-Specific Patterns, Associated with Placental Cadmium Concentrations and Birth Size.

Association and risk of five miRNAs with arsenic-induced multiorgan damage.

Alterations of arsenic levels in arsenicosis residents and awareness of its risk factors: A population-based 20-year follow-up study in a unique coal-borne arsenicosis County in Guizhou, China.

Biomarkers of cadmium, lead and mercury exposure in relation with early biomarkers of renal dysfunction and diabetes: Results from a pilot study among aging Canadians.

Looking Backward: Long-Term Lead Exposure and Risk of Glaucoma article on Bone Lead Levels and Risk of Incident Primary Open-Angle Glaucoma: The VA Normative Aging Study

Assessment of arsenic and polycyclic aromatic hydrocarbon (PAH) exposures on immune function among males in Bangladesh.

Mixtures

Health conditions and occupational risks in a novel group: waste pickers in the largest open garbage dump in Latin America.

Air Pollution

Relations between air pollution and vascular development in 5-year old children: a cross-sectional study in the Netherlands.

Spatial Enablement to Support Environmental, Demographic, Socioeconomics, and Health Data Integration and Analysis for Big Cities: A Case Study With Asthma Hospitalizations in New York City.

Laboratory Studies

BPA/Phenols

Tubulin Acetylation Mediates Bisphenol A Effects on the Microtubule Arrays of Allium cepa and Triticum turgidum

Fluorene-9-bisphenol exposure induces cytotoxicity in mouse oocytes and causes ovarian damage.

Analysis of individual and combined estrogenic effects of bisphenol, nonylphenol and diethylstilbestrol in immature rats with mathematical models.

Protective role of luteolin against bisphenol A-induced renal toxicity through suppressing oxidative stress, inflammation, and upregulating Nrf2/ARE/ HO-1 pathway.

Bisphenol-A induces neurodegeneration through disturbance of intracellular calcium homeostasis in human embryonic stem cells-derived cortical neurons.

Bisphenol A promotes macrophage proinflammatory subtype polarization via upregulation of IRF5 expression in vitro.

Low Doses of Nonylphenol Promote Growth of Colon Cancer Cells through Activation of ERK1/2 via G Protein‒Coupled Receptor 30.

Physiological response of crop plants to the endocrine-disrupting chemical nonylphenol in the soil environment.

Phthalates

Chronic dietary administration of lower levels of diethyl phthalate induces murine testicular germ cell inflammation and sperm pathologies: Involvement of oxidative stress.

Dimethyl phthalate damaged the cell membrane of Escherichia coli K12.

Parabens/Triclosan/Antimicrobials

Larval exposure to environmentally relevant concentrations of triclosan impairs metamorphosis and reproductive fitness in zebrafish.

Persistent Organic Pollutants

The effect of individual and mixtures of mycotoxins and persistent organochloride pesticides on oestrogen receptor transcriptional activation using in vitro reporter gene assays.

Physiological Adaptation to Simultaneous Chronic Exposure to High-Fat Diet and Dichlorodipheniletylhene (DDE) in Wistar Rat Testis.

3-Methylcholanthrene Induces Chylous Ascites in TCDD-Inducible Poly-ADP-Ribose Polymerase (Tiparp) Knockout Mice.

Kinetic and mechanistic insight into the OH-initiated atmospheric oxidation of 2,3,7,8-tetrachlorodibenzo-p-dioxin via OH-addition and hydrogen abstraction pathways: A theoretical investigation.

Assessment of the carcinogenic effect of 2,3,7,8-tetrachlorodibenzo-p-dioxin using mouse embryonic stem cells to form teratoma in vivo.

Aroclor 1254 inhibits vasotocinergic pathways related to osmoregulatory and stress functions in the gilthead sea bream (Sparus aurata, Linnaeus 1758).

Ovarian dysfunction following prenatal exposure to an insecticide, chlordecone, associates with altered epigenetic features.

Development of Biomonitoring Equivalents for chlordane and toxaphene with application to the general Canadian population.

Effect of 2,3,7,8-tetrachlorodibenzo-p-dioxin exposure on acetylcholinesterase during myogenic differentiation of contractile rat primary skeletal muscle cells.

The impact of maternally derived dioxins on embryonic development and hepatic AHR signaling in a long-lived apex predator.

Toxicological effects of furan on the reproductive system of male rats: An “in vitro” and “in vivo”-based endocrinological and spermatogonial study.

Perfluoroalkyl Substances

The PFOS disturbed immunomodulatory functions via nuclear Factor-κB signaling in liver of zebrafish (Danio rerio).

Modulation of neuro-dopamine homeostasis in juvenile female Atlantic cod (Gadus morhua) exposed to polycyclic aromatic hydrocarbons and perfluoroalkyl substances.

PFOA and PFOS interact with superoxide dismutase and induce cytotoxicity in mouse primary hepatocytes: A combined cellular and molecular methods.

Effect of long- and short-chain perfluorinated compounds on cultured thyroid cells viability and response to TSH.

Perfluorooctanoic Acid Enhances Invasion of Follicular Thyroid Carcinoma Cells Through NF-κB and Matrix Metalloproteinase-2 Activation.

Flame Retardants

Rat strain response differences upon exposure to technical or alpha hexabromocyclododecane.

Derivation of the predicted no-effect concentration for organophosphate esters and the associated ecological risk in surface water in China.

Pesticides

The neonicotinoid clothianidin impairs memory processing in honey bees.

Toxicology and human health risk assessment of polyethoxylated tallow amine surfactant used in glyphosate formulations.

The immune responses of the Chinese rare minnow (Gobiocypris rarus) exposed to environmentally relevant concentrations of cypermethrin and subsequently infected by the bacteria Pseudomonas fluorescens.

Temporal-spatial distribution of synthetic pyrethroids in overlying water and surface sediments in Guangzhou waterways: potential input mechanisms and ecological risk to aquatic systems.

Quizalofop-p-Ethyl Induces Adipogenesis in 3T3-L1 Adipocytes. [glyphosate, 2,4-D, dicamba, mesotrione, isoxaflutole, and QpE]

Lethal and sub-lethal effects of imidacloprid on the aphidophagous coccinellid hippodamia variegata.

Nanoparticles of zinc oxide defeat chlorpyrifos-induced immunotoxic effects and histopathological alterations.

TSPO PET Using [18F]PBR111 Reveals Persistent Neuroinflammation Following Acute Diisopropylfluorophosphate Intoxication in the Rat.

Composition and endocrine effects of water collected in the Kibale national park in Uganda.

Pesticide induced visual abnormalities in Asian honey bees (Apis cerana L.) in intensive agricultural landscapes.

Plant essential oils synergize various pyrethroid insecticides and antagonize malathion in Aedes aegypti.

Auxinic herbicides induce oxidative stress on Cnesterodon decemmaculatus (Pisces: Poeciliidae).

Differential Sensitivity to In Vitro Inhibition of Cytochrome P450 Aromatase (CYP19) Activity Among 18 Freshwater Fishes.

Effects of long-term chlorpyrifos exposure on mortality and reproductive tissues of Banded Gourami (Trichogaster fasciata).

Atrazine induced transgenerational reproductive effects in medaka (Oryzias latipes).

Arsenic/Metals

The dynamic changes of arsenic bioaccumulation and antioxidant responses in the marine medaka Oryzias melastigma during chronic exposure.

Metabolism and disposition of arsenic species from controlled dosing with dimethylarsinic acid (DMAV) in adult female CD-1 mice. V. Toxicokinetic studies following oral and intravenous administration.

A comparison of particulate hexavalent chromium cytotoxicity and genotoxicity in human and leatherback sea turtle lung cells from a one environmental health perspective.

Pharmaceuticals

Exposure to 17α-ethinyl estradiol during early pregnancy affects fetal growth and survival in mice.

Microplastics

Polystyrene microbeads modulate the energy metabolism of the marine diatom Chaetoceros neogracile.

Polyester-derived microfibre impacts on the soil-dwelling earthworm Lumbricus terrestris.

Toxicity assessment of pollutants sorbed on environmental sample microplastics collected on beaches: Part I-adverse effects on fish cell line.

Toxicity assessment of pollutants sorbed on environmental microplastics collected on beaches: Part II-adverse effects on Japanese medaka early life stages.

Mixtures

Polluted water from an urban reservoir (Madín dam, México) induces toxicity and oxidative stress in Cyprinus carpio embryos.

Air Pollutants

Glucose Homeostasis following Diesel Exhaust Particulate Matter Exposure in a Lung Epithelial Cell-Specific IKK2-Deficient Mouse Model.

Is air pollution a potential cause of neuronal injury?

BPDE and B[a]P induce mitochondrial compromise by ROS-mediated suppression of the SIRT1/TERT/PGC-1α pathway in spermatogenic cells both in vitro and in vivo.

Benzo[a]pyrene (BaP) exposure generates persistent reactive oxygen species (ROS) to inhibit the NF-κB pathway in medaka (Oryzias melastigma).

Perchlorate

Endocrine disruption alters developmental energy allocation and performance in Rana temporaria.

Sodium perchlorate induces non-alcoholic fatty liver disease in developing stickleback.

Organotins

Toxicity of 4,5-dichloro-2-n-octyl-4-isothiazolin-3-one (DCOIT) in the marine decapod Litopenaeus vannamei. [a replacement chemical for tributyltin]

Miscellaneous

Interaction of Mycotoxin Alternariol with Serum Albumin.

Endocrine disruption by several aniline derivatives and related mechanisms in a human adrenal H295R cell line and adult male zebrafish.

Wildlife/Environment/Exposure Studies

BPA/Phenols

Spatial distribution of parabens, triclocarban, triclosan, bisphenols, and tetrabromobisphenol A and its alternatives in municipal sewage sludges in China.

The effects of urbanization and rainfall on the distribution of, and risks from, phenolic environmental estrogens in river sediment.

The Effect of Dissolved Organic Matter (DOM) on the Release and Distribution of Endocrine-Disrupting Chemicals (Edcs) from Sediment under Hydrodynamic Forces, A Case Study of Bisphenol A (BPA) and Nonylphenol (NP).

Baseline investigation on plasticizers, bisphenol A, polycyclic aromatic hydrocarbons and heavy metals in the surface soil of the informal electronic waste recycling workshops and nearby open dumpsites in Indian metropolitan cities.

Phthalates

Indoor phthalate concentrations in residences in Shihezi, China: implications for preschool children’s exposure and risk assessment.

Prevalence of Eight Phthalate Monoesters in Water from the Okavango Delta, Northern Botswana.

Semi-volatile organic compounds in infant homes: Levels, influence factors, partitioning, and implications for human exposure. [phthalates, PAHs, flame retardants]

Parabens/Triclosan/Antimicrobials/Triclocarban

Contamination and spatial distribution of parabens, their metabolites and antimicrobials in sediment from Korean coastal waters.

Fate of Triclocarban (TCC) in aquatic and terrestrial systems and human exposure.

Human urine contamination with environmental pollutants: simultaneous determination using UPLC-MS/MS.

Persistent Organic Pollutants

Recently listed Stockholm convention POPs: Analytical methodology, occurrence in food and dietary exposure.

Concentrations and accumulation rates of polychlorinated biphenyls in soil along an urban-rural gradient in Shanghai.

Concentrations of legacy persistent organic pollutants and naturally produced MeO-PBDEs in dugongs (Dugong dugon) from Moreton Bay, Australia.

Organochlorine concentrations in aquatic organisms from different trophic levels of the Sundarbans mangrove ecosystem and their implications for human consumption.

Perfluoroalkyl Substances

Occurrence, Removal and Bioaccumulation of Perfluoroalkyl Substances in Lake Chaohu, China.

Flame Retardants

Global Historical Stocks and Emissions of PBDEs.

Pesticides

Ecological risk and estimates of organophosphate pesticides loads into the Central Mediterranean Sea from Volturno River, the river of the “Land of Fires” area, southern Italy.

Pesticide Residues Analysis in Iranian Fruits and Vegetables by Gas Chromatography-Mass Spectrometry.

Neonicotinoid insecticides in surface water from the central Yangtze River, China.

Widespread occurrence of glyphosate in urine from pet dogs and cats in New York State, USA.

Arsenic/Metals

Monitoring of arsenic, mercury and organic pesticides in particulate matter, ambient air and settled dust in natural history collections taking the example of the Museum für Naturkunde, Berlin.

Arsenic enrichment in sediments and beaches of Brazilian coastal waters: A review.

Urinary metals and metal mixtures in midlife women: The Study of Women’s Health Across the Nation (SWAN).

Exposure profile of mercury, lead, cadmium, arsenic, antimony, copper, selenium and zinc in maternal blood, cord blood and placenta: the Tohoku Study of Child Development in Japan.

Health Risk Assessment of Different Heavy Metals Dissolved in Drinking Water.

Trace metals in striped dolphins (Stenella coeruleoalba) stranded along the Murcia coastline, Mediterranean Sea, during the period 2009-2015.

Analysis of occurrence, bioaccumulation and molecular targets of arsenic and other selected volcanic elements in Argentinean Patagonia and Antarctic ecosystems.

Microplastics

Marine debris: A review of impacts and global initiatives.

The complex issue of chemicals and microplastic pollution: A case study in North Pacific lanternfish.

Microplastic Pollution in Surface Water of Urban Lakes in Changsha, China.

Cetaceans and microplastics: First report of microplastic ingestion by a coastal delphinid, Sousa chinensis.

Microplastic contamination in an urban estuary: Abundance and distribution of microplastics and fish larvae in the Douro estuary.

Microplastics’ emissions: Microfibers’ detachment from textile garments.

Miscellaneous

High amounts of chlorinated paraffins in oil-based vitamin E dietary supplements on the German market.

Legal measures to prevent and manage soil contamination and to increase food safety for consumer health: The case of Spain.

This list is not meant to be exhaustive, and generally does not include studies on detection, remediation, or treatment of EDCs. Note that journal publication dates may be different than dates added to PubMed. Compiled by Sarah Howard, Diabetes and Environment Program and HEEDS at Commonweal.

EHN EHN

Endocrine-disrupting chemicals: hazards and opportunities (ECHO) course
by Sarah Howard on October 31, 2024 at 2:50 pm
This course focuses on the chemical, biological, and societal challenges of endocrine-disrupting chemicals (EDCs) and new opportunities for moving forward. ECHO is a two-week intensive bootcamp-style career development course for graduate students, postdoctoral fellows, and professionals in the field. It is held at Woods Hole, Massachusetts.
Lou Guillette Jr. Memorial Symposium
by Sarah Howard on October 22, 2024 at 1:30 pm
On March 14-15, 2025, HEEDS is hosting the Lou Guillette Jr. Memorial Symposium on endocrine disrupting science at the University of Florida. It will celebrate the life and legacy of Dr. Guillette, gather together his trainees and colleagues, and focus on the research topics that Lou made famous. Information here.
Webinar: The overturning of Chevron deference: impacts on environmental health decision making
by Sarah Howard on October 17, 2024 at 4:21 pm
In this Nov. 13 webinar, legal experts will discuss the implications of the overturning of Chevron deference and its profound impact on science, public health and decision-making. Sponsored by CHE and UCSF's EaRTH Center.

EHN EHN

Ultra-processed foods and plastic packaging make for the ultimate toxic pair, scientists say
by Katherine McMahon,Sarah Howard on October 25, 2024 at 10:37 am
A recent paper published in Globalization and Health explores the relationship between ultra-processed foods (UPFs), plastic packaging, and their combined threat to public health. “Consumers do not have the power to solve a problem of this scale, and thus it is the responsibility of policymakers to ensure that transitions away from unhealthy, unsustainable foods are accompanied by structural measures that support demand and access to healthy foods.”
Microplastic exposure linked to reduced sperm quality in humans
by Katherine McMahon,Sarah Howard on October 23, 2024 at 4:29 pm
Exposure to microplastics is associated with a decrease in sperm concentration, motility, and shape, according to a new study published in The Lancet. “The identification of non-stick pan coating material PTFE as a particularly hazardous microplastic for male fertility underscores the importance of targeted interventions to reduce exposure to this and similar substances.”
Exposure to PFAS in ski wax may be linked to high cholesterol
by Katherine McMahon,Sarah Howard on October 16, 2024 at 7:42 pm
According to a new study published in Environmental Research, skiers and snowboarders may face health risks from their exposure to PFAS via ski wax, which can contain up to 100% PFAS by mass. “Interventions to remove PFAS from fluorinated wax could decrease direct exposure to skiers and reduce PFAS release into the environment.”

EHN EHN

Stricter toxic chemical rules reduce Californians’ exposures
by Kristina Marusic on October 31, 2024 at 11:25 am
Californians have lower levels of toxic chemicals linked to cancer, birth defects and reproductive harm in their bodies than people in the rest of the country, according to a new study. The study, published in Environmental Health Perspectives and conducted by researchers at Silent Spring Institute, a nonprofit scientific research organization, and the University of California at Berkeley (UC Berkeley), looked at nationwide data on the levels of 37 toxic chemicals in people’s blood before and after California introduced its stringent regulations. It found that for 18 of these chemicals, Californians have lower levels in their bodies than the rest of the country.
EPA dismissed data on the neurotoxicity of common insecticides
by Katherine McMahon,Sarah Howard on October 30, 2024 at 5:56 pm
A recent paper in Frontiers in Toxicology examined research submitted by industry to the U.S. Environmental Protection Agency (EPA) on the neurotoxicity of neonicotinoids - the most widely used class of insecticides in the U.S. and worldwide - and found that the data was evaluated improperly by the agency. Why this matters: Neonicotinoids are widely used not only for commercial agriculture but also for more personal uses like home gardens and in some flea and tick treatments for pets. Humans are regularly exposed to neonicotinoids – which are structurally similar to nicotine – through the environment, food and water. Neonicotinoids’ popularity partly comes from the belief that their harmful effects are mostly limited to insects, but studies like this one demonstrate that mammals may also be harmed by the chemicals, and highlight the urgent need for stronger regulations around their use.
Pesticide regulations ignore critical threats to insect health and ecosystems
by EHN Curators on October 30, 2024 at 10:26 am
In a study revealing regulatory gaps, researchers found that pesticides impact insect behavior and survival at non-lethal doses, especially in warmer temperatures, calling into question the effectiveness of current pesticide safety protocols. Dave Goulson writes for The Conversation.