New EDC articles, Apr. 3 – 9, 2019 – HEEDS

New EDC articles, Apr. 3 – 9, 2019

Post author:HEEDS
Post published:April 9, 2019
Post category:EDC Science Weekly

A summary of articles on endocrine disrupting chemicals (EDCs) added to PubMed this week.

Contents: Regulations/Policy, Reviews, Human Health Studies, Laboratory Studies, and Wildlife/Environment/Exposure Studies.

Regulations/Policy

EDCs: regulation still lagging behind evidence [editorial in Lancet Diabetes Endocrinol] on the EU report, Endocrine Disruptors: from Scientific Evidence to Human Health Protection

Workshop on the validation and regulatory acceptance of innovative 3R approaches in regulatory toxicology – Evolution versus revolution.

A mode-of-action ontology model for safety evaluation of chemicals: Outcome of a series of workshops on repeated dose toxicity.

Reviews

Environmental Chemicals and Autism: A Scoping Review of the Human and Animal Research.

Parkinson’s Disease and the Environment.

Implications of Environmental Estrogen and Anti-androgen Exposure on Human Health: A focus on the Relationship Between Estrogenicity and Breast Cancer.

Mechanistic Insights of Chemicals and Drugs as Risk Factors for Systemic Lupus Erythematosus.

DNA Methylation in the Pathogenesis of Polycystic Ovary Syndrome.

Applications of metabolomics in assessing ecological effects of emerging contaminants and pollutants on plants.

Triclosan

Research Progress on Toxic Effects and Water Quality Criteria of Triclosan.

Persistent Organic Pollutants

Impact of endocrine disruptor hexachlorobenzene on the mammary gland and breast cancer: The story thus far.

Pesticides

Insight into the confusion over surfactant co-formulants in glyphosate-based herbicides.

Air Pollution

Emerging role of air pollution in autoimmune diseases.

The Effects of the Environment on Asthma Disease Activity.

Inner-City Asthma in Childhood.

Human Health Studies

Environmental Health Education

Environmental Health Sciences in a Translational Research Framework: More than Benches and Bedsides.

Nutrition and Environmental Pollution Extension Curriculum Improved Diet-Related Behaviors and Environmental Health Literacy.

Environmental Health Promotion of a Contaminated Site in Mexico.

BPA/Phenols/Parabens

Chemicals in Consumer Products Associated With Early Puberty [news item in JAMA on Harley et al.’s CHAMCOS findings]

A repeated measures study of phenol, paraben and Triclocarban urinary biomarkers and circulating maternal hormones during gestation in the Puerto Rico PROTECT cohort.

Phthalates

Lactational exposure to phthalates impaired the neurodevelopmental function of infants at 9 months in a pilot prospective study.

Couples exposure to phthalates and its influence on in vitro fertilization outcomes.

Persistent Organic Pollutants

Distribution of Organohalogen and Synthetic Musk Compounds in Breast Adipose Tissue of Breast Cancer Patients in Ulster County, New York, USA.

The relationship of maternal PCB, toxic, and essential trace element exposure levels with birth weight and head circumference in Chiba, Japan.

Flame Retardants

A breast cancer case-control study of polybrominated diphenyl ether (PBDE) serum levels among California women.

Prenatal exposure to organophosphate esters and behavioral development in young children in the Pregnancy, Infection, and Nutrition Study.

Pesticides

The association between 1,3-dichloropropene and asthma emergency department visits in California, USA from 2005 to 2011: a bidirectional-symmetric case crossover study.

Relationship between cumulative exposure to pesticides and sleep disorders among greenhouse vegetable farmers.

Association Between Chronic Exposure to Pesticide and Suicide.

Saliva and urine metabolic profiling reveals altered amino acid and energy metabolism in male farmers exposed to pesticides in Madhya Pradesh State, India.

Effect of pesticide exposure on total antioxidant capacity and biochemical parameters in Brazilian soybean farmers.

Glyphosate Excretion is Associated With Steatohepatitis and Advanced Liver Fibrosis in Patients With Fatty Liver Disease.

Multiple myeloma epidemiology and patient geographic distribution in Canada: A population study.

Arsenic/Metals

Association of plasma and urine metals levels with kidney function: A population-based cross-sectional study in China.

Laboratory Studies

BPA/Phenols

Evaluation of toxicokinetics of nonylphenol in the adult female Sprague-Dawley rats using a physiologically based toxicokinetic model.

Neurotoxicity of BPA, BPS, and BPB for the hippocampal cell line (HT-22): An implication for the replacement of BPA in plastics.

Bisphenol-A exposure induced neurotoxicity in glutamatergic neurons derived from human embryonic stem cells.

Embryonic stem cell- and transcriptomics-based in vitro analyses reveal that bisphenols A, F and S have similar and very complex potential developmental toxicities.

Functional profiling of bisphenols for nuclear receptors.

Bisphenol F has different effects on preadipocytes differentiation and weight gain in adult mice as compared with Bisphenol A and S.

Phthalates

Identification of oxidative stress-related Xdh gene as a Di (2-ethylhexyl) phthalate (DEHP) target and the use of melatonin to alleviate the DEHP-induced impairments in newborn mouse ovaries.

Phthalate side-chain structures and hydrolysis metabolism associated with steroidogenic effects in MLTC-1 Leydig cells.

Prenatal Exposure to Di-(2-ethylhexyl) Phthalate and High-fat Diet Synergistically Disrupts Mouse Fetal Oogenesis and Affects Folliculogenesis.

Exposure to diisononyl phthalate induced an increase in blood pressure through activation of the ACE/ AT1R axis and inhibition of NO production.

Effects of in utero and lactational exposure to phthalates on reproductive development and glycemic homeostasis in rats.

Comparison of the developmental/reproductive toxicity and hepatotoxicity of phthalate esters in rats using an open toxicity data source.

Di(2-ethylhexyl) phthalate promotes lung cancer cell line A549 progression via Wnt/β-catenin signaling.

Di-n-butyl phthalate epigenetically induces reproductive toxicity via the PTEN/AKT pathway.

Parabens

Effects of methylparaben, ethylparaben, and propylparaben on life parameters and sex ratio in the marine copepod Tigriopus japonicus.

Persistent Organic Pollutants

Exposure to Aroclor 1254 persistently suppresses the functions of pancreatic β-cells and deteriorates glucose homeostasis in male mice.

Bioaccumulation and toxicity of methoxychlor on Chinese mitten crab (Eriocheir sinensis).

Effect of the SSeCKS-TRAF6 interaction on gastrodin-mediated protection against 2,3,7,8-tetrachlorodibenzo-p-dioxin-induced astrocyte activation and neuronal death.

Perfluoroalkyl Substances

Effect of perfluorodecanoic acid on pig oocyte viability, intracellular calcium levels and gap junction intercellular communication during oocyte maturation in vitro.

Flame Retardants

DNA damage and methylation induced by organophosphate flame retardants: Tris(2-chloroethyl) phosphate and tris(1-chloro-2-propyl) phosphate in human peripheral blood mononuclear cells.

Screening for neurotoxic potential of 15 flame retardants using freshwater planarians.

Two PBDEs exposure inducing feeding depression and disorder of digestive and antioxidative system of Daphnia magna.

Pesticides

Low dose carbendazim disrupts mouse spermatogenesis might Be through estrogen receptor related histone and DNA methylation.

Changes in the Hypothalamic-Pituitary-Gonadal Axis in Adult Male Rats Poisoned with Proteus and Biscaya Insecticides.

Chronic toxic effects of flutolanil on the liver of zebrafish (Danio rerio).

Organ toxicity attenuation by nanomicelles containing curcuminoids: Comparing the protective effects on tissues oxidative damage induced by diazinon.

Effects of three common pesticides on survival, food consumption and midgut bacterial communities of adult workers Apis cerana and Apis mellifera.

Deciphering the mode of action of pollutants impairing the fish larvae escape response with the vibrational startle response assay.

Comparison of modes of action among different trophic levels of aquatic organisms for pesticides and medications based on interspecies correlations and excess toxicity: Theoretical consideration.

Arsenic/Metals

Arsenic trioxide blocked proliferation and cardiomyocyte differentiation of human induced pluripotent stem cells: Implication in cardiac developmental toxicity.

Impact of Prenatal Arsenate Exposure on Gene Expression in a Pure Population of Migratory Cranial Neural Crest Cells.

Natural variation in C. elegans arsenic toxicity is explained by differences in branched chain amino acid metabolism.

Exposure of low-concentration arsenic-initiated inflammation and autophagy in rat lungs.

Pharmaceuticals

Environmental glucocorticoids corticosterone, betamethasone and flumethasone induce more potent physiological than transcriptional effects in zebrafish embryos.

Seasonal and pharmaceutical-induced changes in selenoprotein glutathione peroxidase 4 activity in the reproductive dynamics of the soil biosentinel Podarcis sicula (Chordata: Reptilia).

Nanoparticles

Induction of 8-hydroxydeoxyguanosine and ultrastructure alterations by silver nanoparticles attributing to placental transfer in pregnant rats and fetuses.

Effect of long-term exposure of silver nanoparticles on growth indices, hematological and biochemical parameters and gonad histology of male goldfish (Carassius auratus gibelio).

Nanoparticles Bearing TSH Receptor Protein and a Tolerogenic Molecule Do Not Induce Immune Tolerance but Exacerbate Thyroid Autoimmunity in hTSHR/NOD.H2h4 Mice.

Microplastics

Bioavailability of microplastic-bound pollutants in vitro: The role of adsorbate lipophilicity and surfactants.

Negligible effects of microplastics on animal fitness and HOC bioaccumulation in earthworm Eisenia fetida in soil.

Mixtures

Polystyrene nanoplastics alter the cytotoxicity of human pharmaceuticals on marine fish cell lines.

Miscellaneous

Developmental exposure to chemicals associated with unconventional oil and gas extraction alters immune homeostasis and viral immunity of the amphibian Xenopus.

Alterations in global DNA methylation and metabolism-related genes caused by zearalenone in MCF7 and MCF10F cells.

Wildlife/Environment/Exposure Studies

BPA/Phenols

Factors affecting interpretation of national biomonitoring data from multiple countries: BPA as a case study.

Bioaccumulation, metabolism, and risk assessment of phenolic endocrine disrupting chemicals in specific tissues of wild fish.

Occurrence of selected endocrine disrupting compounds in Iberian coastal areas and assessment of the environmental risk.

Phthalates

Degradation of phthalate esters in floor dust at elevated relative humidity.

Urinary metabolites of phthalates and di-iso-nonyl cyclohexane-1,2-dicarboxylate (DINCH)-Czech mothers’ and newborns’ exposure biomarkers.

Occurrence and seasonal distribution of microplastics and phthalates in sediments from the urban channel of the Ria and coast of Campeche, Mexico. ]

Toxicity of food contact paper evaluated by combined biological and chemical methods.

Persistent Organic Pollutants

Potential effect of migration strategy on pollutant occurrence in eggs of Arctic breeding barnacle geese (Branta leucopsis). [PCBs, PFASs, mercury]

Temporal trends of PCBs and DDTs in Great Lakes fish compared to those in air.

Review of Polycyclic Aromatic Hydrocarbons (PAHs) Sediment Quality Guidelines for the Protection of Benthic Life.

Thermochemical formation of multiple unintentional persistent organic pollutants on metallurgical fly ash and their correlations.

Persistent Halogenated Organic Pollutants in Surface Water in a Megacity: Distribution Characteristics and Ecological Risks in Wuhan, China. [PCBs, PBDEs]

Food risk characterization from exposure to persistent organic pollutants and metals contaminating eels from an Italian lake.

Perfluoroalkyl Substances

PFOA and PFOS levels in microwave paper packaging between 2005 and 2018.

Propensity of Tagetes erecta L., a Medicinal Plant Commonly Used in Diabetes Management, to Accumulate Perfluoroalkyl Substances.

Field-scale evaluation of the uptake of Perfluoroalkyl substances from soil by rice in paddy fields in South Korea.

Perfluoroalkyl Contaminant Exposure and Effects in Tree Swallows Nesting at Clarks Marsh, Oscoda, Michigan, USA.

Flame Retardants

Occurrence of organophosphate flame retardants in farmland soils from Northern China: Primary source analysis and risk assessment.

Contamination of polybrominated diphenyl ethers (PBDEs) in urban mangroves of Southern China.

Temporal trends in serum polybrominated diphenyl ether concentrations in the Australian population, 2002-2013.

Uptake Kinetics, Accumulation and Long-distance Transport of Organophosphate Esters in Plants: Impacts of Chemical and Plant Properties.

Pesticides

Facial dysplasia in wild forest olive baboons (Papio anubis) in Sebitoli, Kibale National Park, Uganda: Use of camera traps to detect health defects.

Analysis of insecticide exposure in California hummingbirds using liquid chromatography-mass spectrometry.

Neonicotinoid insecticide residues in subsurface drainage and open ditch water around maize fields in southwestern Ontario.

Acetylcholinesterase activity in the brain of wild birds in Korea-2014 to 2016.

Human exposure to banned pesticides reported to the French Poison Control Centers: 2012-2016.

Pesticides and antibiotics in permanent rice, alternating rice-shrimp and permanent shrimp systems of the coastal Mekong Delta, Vietnam.

Arsenic/Metals

Estimation of total arsenic contamination and exposure in Brazilian rice and infant cereals.

Chemical Compositions of Metals in Bhasmas and Tibetan Zuotai Are a Major Determinant of Their Therapeutic Effects and Toxicity.

Health risks to metals in multimedia via ingestion pathway for children in a typical urban area of China.

Total mercury, chromium, nickel and other trace chemical element contents in soils at an old cinnabar mine site (Merník, Slovakia): anthropogenic versus natural sources of soil contamination.

Heavy metals in maternal and cord blood in Beijing and their efficiency of placental transfer.

Sensitivity to cadmium of the endangered freshwater pearl mussel Margaritifera margaritifera from the Dronne River (France): experimental exposure.

Distribution characteristics of heavy metals in surface soils from the western area of Nansi Lake, China.

Microplastics

Evidence of Microplastic Ingestion by Fish from the Bahía Blanca Estuary in Argentina, South America.

Miscellaneous

Dermal exposure to plasticizers in nail polishes: An alternative major exposure pathway of phosphorus-based compounds.

Physiologically based toxicokinetics (PBTK) models for pharmaceuticals and personal care products in wild common carp (Cyprinus carpio).

This list is not meant to be exhaustive, and generally does not include studies on detection, remediation, or treatment of EDCs. Note that journal publication dates may be different than dates added to PubMed.

Compiled by Sarah Howard, Diabetes and Environment Program at Commonweal.

EHN EHN

Webinar: Fluoride, neurodevelopment, and cognition: a National Toxicology Program monograph
by Sarah Howard on November 19, 2024 at 5:00 pm
This Dec. 3 webinar features Dr. Kyla Taylor of NIEHS who will discuss the results of a National Toxicology Program monograph review that concluded there is "moderate confidence" in the scientific evidence that showed an association between higher levels of fluoride exposure and lower IQ in children.
Webinar: Behind the scenes at EPA: What's gone wrong and what does it mean for our work?
by Sarah Howard on November 19, 2024 at 3:56 pm
This Dec. 9 webinar, Behind the scenes at EPA: what's gone wrong and what does it mean for our work? is part 2 of a series on the future of EPA decision-making. Sponsored by the Collaborative for Health and Environment (CHE), Earthjustice, and UCSF's Earth Center.
Endocrine-disrupting chemicals: hazards and opportunities (ECHO) course
by Sarah Howard on October 31, 2024 at 2:50 pm
This course focuses on the chemical, biological, and societal challenges of endocrine-disrupting chemicals (EDCs) and new opportunities for moving forward. ECHO is a two-week intensive bootcamp-style career development course for graduate students, postdoctoral fellows, and professionals in the field. It is held at Woods Hole, Massachusetts.

EHN EHN

“We have enough evidence” to act on toxic plastic exposure now
by Katherine McMahon,Sarah Howard on November 22, 2024 at 3:31 pm
In a recent commentary published in The Lancet, Dr. Leonardo Trasande of NYU’s Grossman School of Medicine emphasizes the need to address the well-established health harms from exposure to chemical additives used in plastics. “Only through a serious and concerted effort to turn off the plastic tap will we apply the lessons learned from plastic use… and avoid the invisible chemicals used in plastic materials from becoming visible in the form of a larger global pandemic of chronic disease.”
Kids who adopt a gluten-free diet have increased arsenic levels
by Katherine McMahon,Sarah Howard on November 20, 2024 at 1:32 pm
A recent study published in The American Journal of Gastroenterology found that children who adopted a gluten-free (GF) diet after being diagnosed with celiac disease had significantly increased arsenic exposure after only six months. “More research needs to be done to determine whether there are long-term effects of this bump, but overall, I think it speaks to the importance of diversifying the grains in the gluten-free diet.”
NIEHS publishes new strategic plan
by Sarah Howard on November 19, 2024 at 6:03 pm
The National Institute of Environmental Health Sciences (NIEHS) published a 2025-2029 strategic plan, "Health at the Intersection of People and Their Environments."

EHN EHN

Trump’s second term could mean fewer protections for drinking water
by EHN Curators on November 21, 2024 at 12:30 pm
Donald Trump’s plans for the Environmental Protection Agency may include rolling back protections against PFAS and other drinking water threats, worrying public health advocates. Hiroko Tabuchi reports for The New York Times.
Kennedy’s fluoride policy faces obstacles
by EHN Curators on November 19, 2024 at 8:28 pm
President-elect Trump’s selection of Robert F. Kennedy Jr. to lead the Department of Health and Human Services won’t give him direct control over water fluoridation policies, though his influence could sway public and local debates. Miranda Willson reports for E&E News.
Scientists' Declaration for the Global Plastics Treaty
by Sarah Howard on November 19, 2024 at 5:54 pm
The signatories of this declaration are independent scientists with expertise on plastics, and who are free of conflicts of interest associated with the life cycle of plastics. Read it here and sign it here. Due Nov. 22, 2024.