New EDC articles, Mar. 20 – 26, 2019

Post author:HEEDS
Post published:March 26, 2019
Post category:EDC Science Weekly

A summary of articles on endocrine disrupting chemicals (EDCs) added to PubMed this week.

Contents: Interesting Articles of the Week, Regulations/Computational Toxicology, Reviews, Human Health Studies, Laboratory Studies, and Wildlife/Environment/Exposure Studies.

Interesting Articles of the Week

There are good clinical, scientific, and social reasons to strengthen links between biomedical and environmental research.

Discovery of common chemical exposures across three continents using silicone wristbands.

Regulations/Computational Toxicology

When are Adverse Outcome Pathways and Associated Assays “Fit for Purpose” for Regulatory Decision-Making and Management of Chemicals?

Advancing Computational Toxicology in the Big Data Era by Artificial Intelligence: Data-Driven and Mechanism-Driven Modeling for Chemical Toxicity.

Exploration of Computational Approaches to Predict the Toxicity of Chemical Mixtures.

Effect-based methods in combination with state-of-the-art chemical analysis for assessment of water quality as integrated approach.

Reviews

The risk of endometriosis after exposure to endocrine-disrupting chemicals: a meta-analysis of 30 epidemiology studies.

Personal Care Products

An insight into toxicity and human-health-related adverse consequences of cosmeceuticals – A review.

BPA

Bisphenol a: A narrative review of prenatal exposure effects on adipogenesis and childhood obesity via peroxisome proliferator-activated receptor gamma.

Pesticides

A review of the factors that influence pesticide residues in pollen and nectar: Future research requirements for optimising the estimation of pollinator exposure.

Pyrethroid pesticide exposure and hematological cancer: epidemiological, biological and molecular evidence.

Human Health Studies

BPA/Phthalates

Association between phthalate exposure and glycosylated hemoglobin, fasting glucose, and type 2 diabetes mellitus: A case-control study in China.

Letters to the editor, and responses:

Language Development of Young Children Is Not Linked to Phthalate Exposure.
Language Development of Young Children Is Not Linked to Phthalate Exposure-Reply.
Re: Historical Perspective: Bisphenol A and phthalates: How environmental chemicals are reshaping toxicology, G.R. Warner and J.A. Flaws, Tox Sci 166: 246-249, 2018.
Response to the comments of Delclos et al.

Persistent Organic Pollutants

Depressive Symptoms After PCB Exposure: Hypotheses for Underlying Pathomechanisms via the Thyroid and Dopamine System.

Endocrine Disrupting-Chemicals and Biochemical Recurrence of Prostate Cancer after Prostatectomy: A cohort study in Guadeloupe (French West Indies).

Perfluoroalkyl Substances

Prenatal exposure to perfluorobutanesulfonic acid and childhood adiposity: A prospective birth cohort study in Shanghai, China.

Structure-based investigation on the association between perfluoroalkyl acids exposure and both gestational diabetes mellitus and glucose homeostasis in pregnant women.

Flame Retardants

Pre and Postnatal Polybrominated Diphenyl Ether Concentrations in Relation to Thyroid Parameters Measured During Early Childhood.

Pesticides

Prenatal and infant exposure to ambient pesticides and autism spectrum disorder in children: population based case-control study
Accompanying editorial: Pesticides and autism

Pesticide exposure and cognitive decline in a rural South Korean population.

Changes in lung function and respiratory symptoms during pesticide spraying season among male sprayers.

A longitudinal follow-up study of oxidative stress and DNA damage among farmers exposed to pesticide mixtures.

Arsenic/Metals

The inverse association of glomerular function and urinary β2-MG excretion and its implications for cadmium health risk assessment.

A missense variant in FTCD affects arsenic metabolism and toxicity phenotypes in Bangladesh.

Miscellaneous

Androgenic and estrogenic indices in human newborns and infants: the MIREC-ID study.

Urinary mycoestrogens and age and height at menarche in New Jersey girls.

Laboratory Studies

BPA/Phenols

Chronic Exposure of Mice to Bisphenol-A Alters Uterine FGF Signaling and Leads to Aberrant Epithelial Proliferation.

In vivo actions of Bisphenol F on the reproductive neuroendocrine system after long-term exposure in zebrafish.

A comparison of endocrine disruption potential of nonylphenol ethoxylate, vanillin ethoxylate, 4-n-nonylphenol and vanillin in vitro.

Associations Between Behavioral Effects of Bisphenol A and DNA Methylation in Zebrafish Embryos.

BPA disrupts the cardioprotection by 17β-oestradiol against ischemia/reperfusion injury in isolated guinea pig hearts.

Scrutinizing the interactions between bisphenol analogues and plasma proteins: Insights from biomimetic liquid chromatography, molecular docking simulations and in silico predictions.

Low doses of Bisphenol A have pro-inflammatory and pro-oxidant effects, stimulate lipid peroxidation and increase the cardiotoxicity of Doxorubicin in cardiomyoblasts.

Comprehensive analysis of transcriptomic changes induced by low and high doses of bisphenol A in HepG2 spheroids in vitro and rat liver in vivo.

Phthalates

Acute toxicity and responses of antioxidant systems to dibutyl phthalate in neonate and adult Daphnia magna.

Taurine protects INS-1 cells from apoptosis induced by Di(2-ethylhexyl) phthalate via reducing oxidative stress and autophagy.

In vitro cytotoxic effects of secondary metabolites of DEHP and its alternative plasticizers DINCH and DINP on a L929 cell line.

Di(2-ethylhexyl) phthalate (DEHP) increases proliferation of epithelial breast cancer cells through progesterone receptor dysregulation.

Transcriptome profiling and pathway analysis of the effects of mono-(2-ethylhexyl) phthalate in mouse Sertoli cells.

Persistent Organic Pollutants

Acute exposure to 4-OH-A, not PCB-1254 , alters brain aromatase activity but does not adversely affect growth in zebrafish.

Transcriptomic analysis of Anabas testudineus and its defensive mechanisms in response to persistent organic pollutants exposure.

Extract of Deschampsia antarctica (EDA) Prevents Dermal Cell Damage Induced by UV Radiation and 2,3,7,8-Tetrachlorodibenzo-p-dioxin.

Perfluoroalkyl Substances

Bioconcentration and tissue distribution of shorter and longer chain perfluoroalkyl acids (PFAAs) in zebrafish (Danio rerio): Effects of perfluorinated carbon chain length and zebrafish protein content.

[Influence of low dose perfluorooctanoate acid exposure to the cell proliferation, migration and invasion of the human muscle rhabdomyosarcoma cell line]. [Chinese]

Flame Retardants

Maternal BDE-209 exposure during lactation perturbs steroidogenesis, germ cell kinetics and THRα1 expression in testes of prepubertal mice offspring.

Effects of tris(1,3-dichloro-2-propyl) phosphate (TDCPP) and triphenyl phosphate (TPP) on sex-dependent alterations of thyroid hormones in adult zebrafish.

The brominated flame retardant PBDE 99 promotes adipogenesis via regulating mitotic clonal expansion and PPARγ expression.

Pesticides

Enantioselectivity of toxicological responses induced by maternal exposure of cis-bifenthrin enantiomers in zebrafish (Danio rerio) larvae.

Effect of diazinon, an organophosphate pesticide, on signal transduction and death induction in mononuclear cells of Nile tilapia fish (Oreochromis niloticus).

Hepatotoxicity and reproductive disruption in male lizards (Eremias argus) exposed to glufosinate-ammonium contaminated soil.

Dietary Tributyrin Attenuates Intestinal Inflammation, Enhances Mitochondrial Function, and Induces Mitophagy in Piglets Challenged with Diquat.

Hepatoprotective effect of Aloe vera against cartap- and malathion-induced toxicity in Wistar rats.

Pentachlorophenol-induced cytotoxicity in human erythrocytes: enhanced generation of ROS and RNS, lowered antioxidant power, inhibition of glucose metabolism, and morphological changes.

Imidacloprid induces adverse effects on fish early life stages that are more severe in Japanese medaka (Oryzias latipes) than in zebrafish (Danio rerio).

Transgenerational and multigenerational stress gene responses to the insecticide etofenprox in Folsomia candida (Collembola).

Spinosad-mediated effects on survival, overall group activity and the midgut of workers of Partamona helleri (Hymenoptera: Apidae).

Effects of two neonicotinoid insecticides on blood cell profiles and corticosterone concentrations of wood frogs (Lithobates sylvaticus).

Studies on the toxic effects of agrochemical pesticide (Monocrotophos) on physiological and reproductive behavior of indigenous and exotic earthworm species.

Acute and chronic toxicity of neonicotinoid and butenolide insecticides to the freshwater amphipod, Hyalella azteca.

Effects of Sublethal Chlorpyrifos Exposure on Postlarval American Lobster (Homarus americanus).

Pyrethroid neurotoxicity studies with bifenthrin indicate a mixed Type I/II mode of action.

Exposure of low-dose fipronil enantioselectively induced anxiety-like behavior associated with DNA methylation changes in embryonic and larval zebrafish.

Persistent behavior deficits, neuroinflammation, and oxidative stress in a rat model of acute organophosphate intoxication.

Arsenic/Metals

Chronic arsenic exposure in drinking water interferes with the balances of T lymphocyte subpopulations as well as stimulates the functions of dendritic cells in vivo.

Targeted Degradation of Glucose Transporters Protects Against Arsenic Toxicity.

Silencing GSK3β instead of DKK1 can inhibit osteogenic differentiation caused by co-exposure to fluoride and arsenic.

Lead alters intracellular protein signaling and suppresses pro-inflammatory activation in TLR4 and IFNR-stimulated murine RAW 264.7 cells, in vitro.

Green olive leaf extract (OLE) provides cytoprotection in renal cells exposed to low doses of cadmium.

Chronic low dose arsenic exposure preferentially perturbs mitotic phase of the cell cycle.

Long-Term Combinatorial Exposure to Trichloroethylene and Inorganic Arsenic in Genetically Heterogeneous Mice Results in Renal Tubular Damage and Cancer-Associated Molecular Changes.

The relative importance of waterborne and dietborne As exposure on survival and growth of juvenile fathead minnows.

Gallic acid ameliorates sodium arsenite-induced renal and hepatic toxicity in rats.

Wildlife/Environment/Exposure Studies

BPA/Phenols

Determination of four parabens and bisphenols A, F and S in human breast milk using QuEChERS and liquid chromatography coupled to mass spectrometry.

Plasticizers and BPA in spices and aromatic herbs of Mediterranean areas.

Phthalates

Receptor-based aggregate exposure assessment of phthalates based on individual’s simultaneous use of multiple cosmetic products.

Inter-Day Variability of Metabolites of DEHP and DnBP in Human Urine-Comparability of the Results of Longitudinal Studies with a Cross-Sectional Study.

Persistent Organic Pollutants

Examining the role of total organic carbon and black carbon in the fate of legacy persistent organic pollutants (POPs) in indoor dust from Nepal: Implication on human health.

Trace elements and POPs in two commercial shark species from Djibouti: Implications for human exposure.

Organohalogenated pollutants in raw and UHT cow’s milk from Turkey: a risk assessment of dietary intake.

Insight into occurrence, profile and spatial distribution of organochlorine pesticides in soils of solid waste dumping sites of Pakistan: Influence of soil properties and implications for environmental fate.

Trends of persistent organic pollutants in ringed seals (Phoca hispida) from the Canadian Arctic.

Evidence of impacts from DDT in pelican, cormorant, stork, and egret eggs from KwaZulu-Natal, South Africa.

Indicator PCBs in farmed and wild fish in Greece – Risk assessment for the Greek population.

Effects of migration and reproduction on the variation in persistent organic pollutant levels in Kentish Plovers from Cangzhou Wetland, China.

Perfluoroalkyl Substances

Do conventional cooking methods alter concentrations of per- and polyfluoroalkyl substances (PFASs) in seafood?

Occurrence and health risk of perfluoroalkyl acids (PFAAs) in seafood from Yellow Sea, China.

Per- and polyfluoroalkyl substances (PFAS) in Australia: Current levels and estimated population reference values for selected compounds.

Occurrence of perfluorinated compounds in agricultural environment, vegetables, and fruits in regions influenced by a fluorine-chemical industrial park in China.

Flame Retardants

A review on organophosphate Ester (OPE) flame retardants and plasticizers in foodstuffs: Levels, distribution, human dietary exposure, and future directions.

Brominated flame retardants in atmospheric fine particles in the Beijing-Tianjin-Hebei region, China: Spatial and temporal distribution and human exposure assessment.

Organophosphate flame retardants in college dormitory dust of northern Chinese cities: Occurrence, human exposure and risk assessment.

Bioaccumulation of selected halogenated organic flame retardants in Lake Ontario.

Pesticides

Part of the solution – an engaged scholarship approach for the sustainable reduction of street pesticides and poisonings.

A neonicotinoid pesticide impairs foraging, but not learning, in free-flying bumblebees.

Urinary monitoring of neonicotinoid imidacloprid exposure to pesticide applicators.

An integrated assessment of water quality in a land reform settlement in northern Rio de Janeiro state, Brazil.

Gonad pathology and intersex severity in pelagic (Tilapia zilli) and benthic (Neochanna diversus and Clarias gariepinus) species from a pesticide-impacted agrarian catchment, south-south Nigeria.

Occurrence of Urban-Use Pesticides and Management with Enhanced Stormwater Control Measures at the Watershed Scale.

Arsenic/Metals

A Review of Metal Exposure Studies Conducted in the Rural Southwestern and Mountain West Region of the United States.

Heavy metals content in some non-alcoholic beverages (carbonated drinks, flavored yogurt drinks, and juice drinks) of the Egyptian markets.

On the Use of Hair Analysis for Assessing Arsenic Intoxication.

A current perspective on arsenic in wines: Analysis, speciation and changes in composition during production.

Advantages and disadvantages of different pre-cooking and cooking methods in removal of essential and toxic metals from various rice types- human health risk assessment in Tehran households, Iran.

Metal and metalloid levels in blood of semipalmated sandpipers (Calidris pusilla) from Brazil, Suriname, and Delaware Bay: Sentinels of exposure to themselves, their prey, and predators that eat them.

Health risk assessment of potentially harmful elements in subsidence water bodies using a Monte Carlo approach: An example from the Huainan coal mining area, China.

Unraveling prevalence and public health risks of arsenic, uranium and co-occurring trace metals in groundwater along riverine ecosystem in Sindh and Punjab, Pakistan.

Pharmaceuticals

Occurrence and ecological risk of pharmaceuticals and personal care products (PPCPs) and pesticides in typical surface watersheds, China.

Contaminants of emerging concern in a freeze-thaw river during the spring flood.

Microplastics

I will include more on microplastics now; here are some recent articles and reviews:

Estimating the mass of chemicals associated with ocean plastic pollution to inform mitigation efforts.

Microplastics and synthetic particles ingested by deep-sea amphipods in six of the deepest marine ecosystems on Earth.

Fish and Seabird Gut Conditions Enhance Desorption of Estrogenic Chemicals from Commonly-Ingested Plastic Items.

Microplastics in cosmetics: Environmental issues and needs for global bans.

Microplastics in the marine environment: Current trends in environmental pollution and mechanisms of toxicological profile.

Microplastic exposure and effects in aquatic organisms: A physiological perspective.

Microplastics in freshwaters and drinking water: Critical review and assessment of data quality.

Microplastic pollution in the rivers of the Tibet Plateau.

Microplastic abundance, distribution and composition in water, sediments, and wild fish from Poyang Lake, China.

Seafloor sediments as microplastic sinks in the northern Baltic Sea – Negligible upward transport of buried microplastics by bioturbation.

Microplastics in the surface sediments from the eastern waters of Java Sea, Indonesia.

Prevalence of microplastic pollution in the Northwestern Pacific Ocean.

PAHs, pesticides, personal care products and plastic additives in plastic debris from Spanish Mediterranean beaches.

Microplastic ingestion ubiquitous in marine turtles.

Miscellaneous

Integrated Assessment of Wastewater Reuse, Exposure Risk, and Fish Endocrine Disruption in the Shenandoah River Watershed.

Retinoids and oestrogenic endocrine disrupting chemicals in saline sewage treatment plants: Removal efficiencies and ecological risks to marine organisms.

Assessment of targeted non-intentionally added substances in cosmetics in contact with plastic packagings. Analytical and toxicological aspects.

Induction of nuclear abnormalities in herring (Clupea harengus membras), flounder (Platichthys flesus), and Atlantic cod (Gadus morhua) collected from the southern part of the Gotland Basin-the Baltic Sea (2010-2017).

This list is not meant to be exhaustive, and generally does not include studies on detection, remediation, or treatment of EDCs. Note that journal publication dates may be different than dates added to PubMed. Compiled by Sarah Howard,

Diabetes and Environment Program at Commonweal.

EHN EHN

Endocrine-disrupting chemicals: hazards and opportunities (ECHO) course
by Sarah Howard on October 31, 2024 at 2:50 pm
This course focuses on the chemical, biological, and societal challenges of endocrine-disrupting chemicals (EDCs) and new opportunities for moving forward. ECHO is a two-week intensive bootcamp-style career development course for graduate students, postdoctoral fellows, and professionals in the field. It is held at Woods Hole, Massachusetts.
Lou Guillette Jr. Memorial Symposium
by Sarah Howard on October 22, 2024 at 1:30 pm
On March 14-15, 2025, HEEDS is hosting the Lou Guillette Jr. Memorial Symposium on endocrine disrupting science at the University of Florida. It will celebrate the life and legacy of Dr. Guillette, gather together his trainees and colleagues, and focus on the research topics that Lou made famous. Information here.
Webinar: The overturning of Chevron deference: impacts on environmental health decision making
by Sarah Howard on October 17, 2024 at 4:21 pm
In this Nov. 13 webinar, legal experts will discuss the implications of the overturning of Chevron deference and its profound impact on science, public health and decision-making. Sponsored by CHE and UCSF's EaRTH Center.

EHN EHN

Ultra-processed foods and plastic packaging make for the ultimate toxic pair, scientists say
by Katherine McMahon,Sarah Howard on October 25, 2024 at 10:37 am
A recent paper published in Globalization and Health explores the relationship between ultra-processed foods (UPFs), plastic packaging, and their combined threat to public health. “Consumers do not have the power to solve a problem of this scale, and thus it is the responsibility of policymakers to ensure that transitions away from unhealthy, unsustainable foods are accompanied by structural measures that support demand and access to healthy foods.”
Microplastic exposure linked to reduced sperm quality in humans
by Katherine McMahon,Sarah Howard on October 23, 2024 at 4:29 pm
Exposure to microplastics is associated with a decrease in sperm concentration, motility, and shape, according to a new study published in The Lancet. “The identification of non-stick pan coating material PTFE as a particularly hazardous microplastic for male fertility underscores the importance of targeted interventions to reduce exposure to this and similar substances.”
Exposure to PFAS in ski wax may be linked to high cholesterol
by Katherine McMahon,Sarah Howard on October 16, 2024 at 7:42 pm
According to a new study published in Environmental Research, skiers and snowboarders may face health risks from their exposure to PFAS via ski wax, which can contain up to 100% PFAS by mass. “Interventions to remove PFAS from fluorinated wax could decrease direct exposure to skiers and reduce PFAS release into the environment.”

EHN EHN

Stricter toxic chemical rules reduce Californians’ exposures
by Kristina Marusic on October 31, 2024 at 11:25 am
Californians have lower levels of toxic chemicals linked to cancer, birth defects and reproductive harm in their bodies than people in the rest of the country, according to a new study. The study, published in Environmental Health Perspectives and conducted by researchers at Silent Spring Institute, a nonprofit scientific research organization, and the University of California at Berkeley (UC Berkeley), looked at nationwide data on the levels of 37 toxic chemicals in people’s blood before and after California introduced its stringent regulations. It found that for 18 of these chemicals, Californians have lower levels in their bodies than the rest of the country.
EPA dismissed data on the neurotoxicity of common insecticides
by Katherine McMahon,Sarah Howard on October 30, 2024 at 5:56 pm
A recent paper in Frontiers in Toxicology examined research submitted by industry to the U.S. Environmental Protection Agency (EPA) on the neurotoxicity of neonicotinoids - the most widely used class of insecticides in the U.S. and worldwide - and found that the data was evaluated improperly by the agency. Why this matters: Neonicotinoids are widely used not only for commercial agriculture but also for more personal uses like home gardens and in some flea and tick treatments for pets. Humans are regularly exposed to neonicotinoids – which are structurally similar to nicotine – through the environment, food and water. Neonicotinoids’ popularity partly comes from the belief that their harmful effects are mostly limited to insects, but studies like this one demonstrate that mammals may also be harmed by the chemicals, and highlight the urgent need for stronger regulations around their use.
Pesticide regulations ignore critical threats to insect health and ecosystems
by EHN Curators on October 30, 2024 at 10:26 am
In a study revealing regulatory gaps, researchers found that pesticides impact insect behavior and survival at non-lethal doses, especially in warmer temperatures, calling into question the effectiveness of current pesticide safety protocols. Dave Goulson writes for The Conversation.