New EDC articles, Mar. 13 – 19, 2019 – HEEDS

New EDC articles, Mar. 13 – 19, 2019

Post author:HEEDS
Post published:March 19, 2019
Post category:EDC Science Weekly

A summary of articles on endocrine disrupting chemicals (EDCs) added to PubMed this week.

Contents: Reviews, Human Health Studies, Laboratory Studies, and Wildlife/Environment/Exposure Studies.

Reviews

Effect of environmental and pharmaceutical exposures on fetal testis development and function: a systematic review of human experimental data.

Children’s Environmental Health in South and Southeast Asia: Networking for Better Child Health Outcomes.

Environmental toxins and the impact of other endocrine disrupting chemicals in women’s reproductive health.

Impact of Estrogens on the Regulation of White, Beige, and Brown Adipose Tissue Depots.

Gene-environment interactions in Alzheimer’s Disease: A potential path to precision medicine.

Prenatal Exposure to Endocrine Disruptors and Cardiometabolic Risk in Preschoolers: A Systematic Review Based on Cohort Studies.

Exposure to environmental chemicals and type 1 diabetes: an update. [full disclosure: I wrote this one]

Microplastics

Microplastic exposure and effects in aquatic organisms: A physiological perspective.

Microplastics in the marine environment: Current trends in environmental pollution and mechanisms of toxicological profile.

Metals/Arsenic

Oncogenic role of arsenic exposure in lung cancer: A forgotten risk factor.

The Role of Selenium in Arsenic and Cadmium Toxicity: an Updated Review of Scientific Literature.

Potential Role of Metal Chelation to Prevent the Cardiovascular Complications of Diabetes.

Toxic effects of lead exposure on bioaccumulation, oxidative stress, neurotoxicity, and immune responses in fish: A review.

Human Health Studies

Phthalates

Urinary concentrations of phthalate biomarkers and weight change among postmenopausal women: a prospective cohort study.

Prenatal and childhood exposure to phthalate diesters and neurobehavioral development in a 15-year follow-up birth cohort study.

Identifying periods of susceptibility to the impact of phthalates on children’s cognitive abilities.

Use of phthalate-containing prescription drugs and the risk of gastric cancer: a Danish nationwide case-control study.

Follicular fluid concentrations of phthalate metabolites are associated with altered intrafollicular reproductive hormones in women undergoing in vitro fertilization.

Antimicrobials

Association of antimicrobial household exposure with development of allergic rhinitis in Korea.

Persistent Organic Pollutants

Cancer incidence in an Austrian alpine valley 1983-2012 : A descriptive study.

Flame Retardants

A preliminary study on prenatal polybrominated diphenyl ether serum concentrations and intrinsic functional network organization and executive functioning in childhood.

Pesticides

ERCC6L2 rs591486 polymorphism and risk for amyotrophic lateral sclerosis in Greek population.

Pesticide use and risk of non-Hodgkin lymphoid malignancies in agricultural cohorts from France, Norway and the USA: a pooled analysis from the AGRICOH consortium.

Arsenic/Metals

Socioeconomic status and the association between arsenic exposure and type 2 diabetes.

Telomere length, arsenic exposure and risk of basal cell carcinoma of skin.

Hypospadias Risk from Maternal Residential Exposure to Heavy Metal Hazardous Air Pollutants.

Miscellaneous

Mining leachate contamination and subfecundity among women living near the USA-Mexico border.

Cardiopulmonary Effects of Fine Particulate Matter Exposure among Older Adults, during Wildfire and Non-Wildfire Periods, in the United States 2008-2010.

Elevated autoimmunity in residents living near abandoned uranium mine sites on the Navajo Nation.

Laboratory Studies

BPA/Phenols

Nonylphenol attenuates SOCS3 expression and M1 polarization in lipopolysaccharide-treated rat splenic macrophages.

Bisphenol A analogues bisphenol B, bisphenol F, and bisphenol S induce oxidative stress, disrupt daily sperm production, and damage DNA in rat spermatozoa: a comparative in vitro and in vivo study.

Searching for a bisphenol A substitute: Effects of bisphenols on catalase molecules and human red blood cells.

Bisphenol P activates hormonal genes and introduces developmental outcomes in Chironomus tentans.

The influence of low dose Bisphenol A on whole genome DNA methylation and chromatin compaction in different human cell lines.

Time-dependent transcriptomic responses of Daphnia magna exposed to metabolic disruptors that enhanced storage lipid accumulation. [BPA, a pesticide, and tributyltin]

Atrazine or bisphenol A mediated negative modulation of mismatch repair gene, mlh1 leads to defective oogenesis and reduced female fertility in Drosophila melanogaster.

Phthalates

MEHP promotes the proliferation of oral cancer cells via down regulation of miR-27b-5p and miR-372-5p.

Effects of di-n-butyl phthalate on rhizosphere and non-rhizosphere soil microbial communities at different growing stages of wheat.

Effects of citrate ester plasticizers and bis (2-ethylhexyl) phthalate in the OECD 28-day repeated-dose toxicity test (OECD TG 407).

Di(2-ethylhexyl) phthalate promotes hepatic fibrosis by regulation of oxidative stress and inflammation responses in rats.

Persistent Organic Pollutants

Developmental Dieldrin Exposure Alters DNA Methylation at Genes Related to Dopaminergic Neuron Development and Parkinson’s Disease in Mouse Midbrain.

Gender and dose-related metabolome alterations in rat offspring after in utero and lactational exposure to PCB 180.

Perfluoroalkyl Substances

The concentration of dissolved organic matter impacts the metabolic response in Daphnia magna exposed to 17α-ethynylestradiol and perfluorooctane sulfonate.

Comparative Hepatotoxicity of Novel PFOA Alternatives (Perfluoropolyether Carboxylic Acids) on Male Mice.

Neuroprotective effects of blueberry anthocyanins against perfluorooctanoic sulfonate on planarian Dugesia japonica.

Flame Retardants

[The role of abnormal mitochondrial fusion and fission in PBDE-47-induced change in mitochondrial mass in PC12 cells]. [abstract in English, article in Chinese]

Pesticides

The Ramazzini Institute 13-week pilot study glyphosate-based herbicides administered at human-equivalent dose to Sprague Dawley rats: effects on development and endocrine system

Aberrant neurotransmissional mRNAs in cerebral ganglions of rotenone-exposed Lumbricus terrestris exhibiting motor dysfunction and altered cognitive behavior.

Developmental and epigenetic effects of Roundup and glyphosate exposure on Japanese medaka (Oryzias latipes).

Comparative studies on endogenic stress hormones, antioxidant, biochemical and hematological status of metabolic disturbance in albino rat exposed to roundup herbicide and its active ingredient glyphosate.

Negative impact of Novaluron on the nontarget insect Bombyx mori (Lepidoptera: Bombycidae).

Toxic effects of oxine-copper on development and behavior in the embryo-larval stages of zebrafish.

Expression of immune, antioxidant and stress related genes in different organs of common carp exposed to indoxacarb.

Oxidative stress and neuromodulatory effects of deltamethrin and its combination with insect repellents in rats.

Assessing Impacts of Insecticides on Different Embryonic Stages of the Non-target Aquatic Insect Cheumatopsyche brevilineata (Trichoptera: Hydropsychidae).

Study of the Potential Endocrine-Disrupting Effects of Phenylurea Compounds on Neurohypophysis Cells In Vitro.

Effects of prenatal exposure to temephos on behavior and social interaction.

Sub-lethal effects of dimethoate alone and in combination with cadmium on biochemical parameters in freshwater snail, Galba truncatula.

Nucleolar alterations are reliable parameters to determine the cytogenotoxicity of environmental pollutants. [atrazine, cadmium, etc.]

Arsenic/Metals

Developmental exposure to mercury chloride impairs social behavior in male offspring dependent on genetic background and maternal autoimmune environment.

Grape seed proanthocyanidin extract alleviates arsenic-induced lung damage through NF-κB signaling.

Heavy metals transported through a multi-trophic food chain influence the energy metabolism and immune responses of Cryptolaemus montrouzieri.

Effects of Arsenic on Gut Microbiota and Its Biotransformation Genes in Earthworm Metaphire sieboldi.

Organotins

Genotoxic Effects of Tributyltin and Triphenyltin Isothiocyanates, Cognate RXR Ligands: Comparison in Human Breast Carcinoma MCF 7 and MDA-MB-231 Cells. In Silico Molecular Docking and In Vivo Validation with Caenorhabditis elegans to Discover Molecular Initiating Events in Adverse Outcome Pathway Framework: Case Study on Endocrine-Disrupting Chemicals with Estrogen and Androgen Receptors.

Screening

High-throughput screening and classification of chemicals and their effects on neuronal gene expression using RASL-seq. [re autism]

Miscellaneous

In Silico Molecular Docking and In Vivo Validation with Caenorhabditis elegans to Discover Molecular Initiating Events in Adverse Outcome Pathway Framework: Case Study on Endocrine-Disrupting Chemicals with Estrogen and Androgen Receptors.

Wildlife/Environment/Exposure Studies

BPA/Phenols

Biomonitoring of bisphenols A, F, S in human milk and probabilistic risk assessment for breastfed infants.

Persistent Organic Pollutants

Time trends of persistent organic pollutants in 30 year olds sampled in 1986, 1994, 2001 and 2007 in Northern Norway: Measurements, mechanistic modeling and a comparison of study designs.

Persistent organic pollutants in fish: biomonitoring and cocktail effect with implications for food safety.

Level of endosulfan among women in Talwandi Sabo Block of Southern Punjab, India.

Characterization of PCDD/Fs and dioxin-like PCBs in flue gas from thermal industrial processes in Vietnam: A comprehensive investigation on emission profiles and levels.

Thermal oxidation of dieldrin and concomitant formation of toxic products including polychlorinated dibenzo-p-dioxin and dibenzofuran (PCDD/F).

Perfluoroalkyl Substances

Leaching and transport of PFAS from aqueous film-forming foam (AFFF) in the unsaturated soil at a firefighting training facility under cold climatic conditions.

Flame Retardants

Health Risks of Polybrominated Diphenyl Ethers (PBDEs) and Metals at Informal Electronic Waste Recycling Sites.

Uptake and translocation of organophosphate flame retardants (OPFRs) by hydroponically grown wheat (Triticum aestivum L.).

Species-specific debromination of polybromodiphenyl ethers determined by deiodinase activity in fish.

Pesticides

Effects of Neonicotinoid Insecticides on Physiology and Reproductive Characteristics of Captive Female and Fawn White-tailed Deer.

Comprehensive investigation of pesticides in Brazilian surface water by high resolution mass spectrometry screening and gas chromatography-mass spectrometry quantitative analysis.

Arsenic/Metals

Results of the first national human biomonitoring in Slovenia: Trace elements in men and lactating women, predictors of exposure and reference values.

A Tale of Two Water Supplies in China: Finding Practical Solutions to Urban and Rural Water Supply Problems. [arsenic, etc.]

Assessment of potential dietary toxicity and arsenic accumulation in two contrasting rice genotypes: Effect of soil amendments.

Analysis of Heavy Metals in Foodstuffs and an Assessment of the Health Risks to the General Public via Consumption in Beijing, China.

Potential Co-exposure to Arsenic and Fluoride and Biomonitoring Equivalents for Mexican Children.

Exposure to Mixtures of Pollutants in Mexican Children from Marginalized Urban Areas.

The effects of arsenic speciation on accumulation and toxicity of dietborne arsenic exposures to rainbow trout.

Arsenic exposure of child populations in Northern Argentina.

Barbary sheep tissues as bioindicators of radionuclide and stabile element contamination in Croatia: exposure assessment for consumers.

Miscellaneous

Passive sampling of polar emerging contaminants in Irish catchments. [EDCs, pharmaceuticals, pesticides]

Land Use Contributions to Adverse Biological Effects in a Complex Agricultural and Urban.

This list is not meant to be exhaustive, and generally does not include studies on detection, remediation, or treatment of EDCs. Note that journal publication dates may be different than dates added to PubMed. Compiled by Sarah Howard, Diabetes and Environment Program at Commonweal.

EHN EHN

Endocrine-disrupting chemicals: hazards and opportunities (ECHO) course
by Sarah Howard on October 31, 2024 at 2:50 pm
This course focuses on the chemical, biological, and societal challenges of endocrine-disrupting chemicals (EDCs) and new opportunities for moving forward. ECHO is a two-week intensive bootcamp-style career development course for graduate students, postdoctoral fellows, and professionals in the field. It is held at Woods Hole, Massachusetts.
Lou Guillette Jr. Memorial Symposium
by Sarah Howard on October 22, 2024 at 1:30 pm
On March 14-15, 2025, HEEDS is hosting the Lou Guillette Jr. Memorial Symposium on endocrine disrupting science at the University of Florida. It will celebrate the life and legacy of Dr. Guillette, gather together his trainees and colleagues, and focus on the research topics that Lou made famous. Information here.
Webinar: The overturning of Chevron deference: impacts on environmental health decision making
by Sarah Howard on October 17, 2024 at 4:21 pm
In this Nov. 13 webinar, legal experts will discuss the implications of the overturning of Chevron deference and its profound impact on science, public health and decision-making. Sponsored by CHE and UCSF's EaRTH Center.

EHN EHN

Ultra-processed foods and plastic packaging make for the ultimate toxic pair, scientists say
by Katherine McMahon,Sarah Howard on October 25, 2024 at 10:37 am
A recent paper published in Globalization and Health explores the relationship between ultra-processed foods (UPFs), plastic packaging, and their combined threat to public health. “Consumers do not have the power to solve a problem of this scale, and thus it is the responsibility of policymakers to ensure that transitions away from unhealthy, unsustainable foods are accompanied by structural measures that support demand and access to healthy foods.”
Microplastic exposure linked to reduced sperm quality in humans
by Katherine McMahon,Sarah Howard on October 23, 2024 at 4:29 pm
Exposure to microplastics is associated with a decrease in sperm concentration, motility, and shape, according to a new study published in The Lancet. “The identification of non-stick pan coating material PTFE as a particularly hazardous microplastic for male fertility underscores the importance of targeted interventions to reduce exposure to this and similar substances.”
Exposure to PFAS in ski wax may be linked to high cholesterol
by Katherine McMahon,Sarah Howard on October 16, 2024 at 7:42 pm
According to a new study published in Environmental Research, skiers and snowboarders may face health risks from their exposure to PFAS via ski wax, which can contain up to 100% PFAS by mass. “Interventions to remove PFAS from fluorinated wax could decrease direct exposure to skiers and reduce PFAS release into the environment.”

EHN EHN

Stricter toxic chemical rules reduce Californians’ exposures
by Kristina Marusic on October 31, 2024 at 11:25 am
Californians have lower levels of toxic chemicals linked to cancer, birth defects and reproductive harm in their bodies than people in the rest of the country, according to a new study. The study, published in Environmental Health Perspectives and conducted by researchers at Silent Spring Institute, a nonprofit scientific research organization, and the University of California at Berkeley (UC Berkeley), looked at nationwide data on the levels of 37 toxic chemicals in people’s blood before and after California introduced its stringent regulations. It found that for 18 of these chemicals, Californians have lower levels in their bodies than the rest of the country.
EPA dismissed data on the neurotoxicity of common insecticides
by Katherine McMahon,Sarah Howard on October 30, 2024 at 5:56 pm
A recent paper in Frontiers in Toxicology examined research submitted by industry to the U.S. Environmental Protection Agency (EPA) on the neurotoxicity of neonicotinoids - the most widely used class of insecticides in the U.S. and worldwide - and found that the data was evaluated improperly by the agency. Why this matters: Neonicotinoids are widely used not only for commercial agriculture but also for more personal uses like home gardens and in some flea and tick treatments for pets. Humans are regularly exposed to neonicotinoids – which are structurally similar to nicotine – through the environment, food and water. Neonicotinoids’ popularity partly comes from the belief that their harmful effects are mostly limited to insects, but studies like this one demonstrate that mammals may also be harmed by the chemicals, and highlight the urgent need for stronger regulations around their use.
Pesticide regulations ignore critical threats to insect health and ecosystems
by EHN Curators on October 30, 2024 at 10:26 am
In a study revealing regulatory gaps, researchers found that pesticides impact insect behavior and survival at non-lethal doses, especially in warmer temperatures, calling into question the effectiveness of current pesticide safety protocols. Dave Goulson writes for The Conversation.