New EDC articles, Mar. 6 – 12, 2019

A summary of articles on endocrine disrupting chemicals (EDCs) added to PubMed this week.

Contents: Interesting Research of the Week, Regulations/Policy, Reviews, Human Health Studies, Laboratory Studies, and Wildlife/Environment/Exposure Studies.

Interesting Research of the Week

Pilot Study on the Effect of Orally Administered Bisphenol A on Glucose and Insulin Response in Nonobese Adults.

Regulations/Policy

Endocrine disruptors and the future of toxicology testing – lessons from CLARITY-BPA.

The next generation blueprint of computational toxicology at the U.S. Environmental Protection Agency.

Practical advice for selecting or determining trophic magnification factors for application under the European Union Water Framework Directive.

Reviews

Exposure to environmental toxicants and young children’s cognitive and social development.

The Beneficial and Debilitating Effects of Environmental and Microbial Toxins, Drugs, Organic Solvents and Heavy Metals on the Onset and Progression of Multiple Sclerosis.

BPA

The Endocrine Disruptor Bisphenol A (BPA) Exerts a Wide Range of Effects in Carcinogenesis and Response to Therapy.

Perfluoroalkyl Substances

Assessing the human health risks of perfluorooctane sulfonate by in vivo and in vitro studies.

Arsenic

Pathways of arsenic uptake and efflux.

Human Health Studies

Phthalates

Urinary phthalate metabolites among children in Saudi Arabia: Occurrences, risks, and their association with oxidative stress markers.

Parabens

Parabens exposure in early pregnancy and gestational diabetes mellitus.

Persistent Organic Pollutants

DDT Exposure during Pregnancy and DNA Methylation Alterations in Female Offspring in the Child Health and Development Study.

Polyunsaturated fatty acids and child neurodevelopment among a population exposed to DDT: a cohort study.

Comparative analyses of the 12 most abundant PCB congeners detected in human maternal serum for activity at the thyroid hormone receptor and ryanodine receptor.

The 2nd to 4th digit length ratio (2D:4D) among children of Seveso women exposed to 2,3,7,8-tetrachlorodibenzo-p-dioxin.

Adverse effects of maternal dioxin exposure on fetal brain development before birth assessed by neonatal electroencephalography (EEG) leading to poor neurodevelopment; a 2-year follow-up study.

Perfluoroalkyl Substances

Serum perfluoroalkyl substances and lung function in adolescents exposed to the World Trade Center disaster.

Perfluoroalkyl substances, metabolomic profiling, and alterations in glucose homeostasis among overweight and obese Hispanic children: A proof-of-concept analysis.

Perfluorinated substances, risk factors for multiple sclerosis and cellular immune activation.

Dynamics of associations between perfluoroalkyl substances and uric acid across the various stages of glomerular function.

Pesticides

Prenatal exposure to the herbicide 2,4-D is associated with deficits in auditory processing during infancy.

Arsenic/Metals

Prenatal arsenic exposure alters the placental expression of multiple epigenetic regulators in a sex-dependent manner.

The associations between lead exposure at multiple sensitive life periods and dental caries risks in permanent teeth.

Placental metal concentrations in relation to placental growth, efficiency and birth weight.

Early-Life Cadmium Exposure and Bone-Related Biomarkers: A Longitudinal Study in Children.

Miscellaneous

Stable consumption of swordfish favors, whereas stable consumption of oily fish protects from, development of postpartum thyroiditis.

Laboratory Studies

BPA/Phenols

Bisphenol A inhibits mucin 2 secretion in intestinal goblet cells through mitochondrial dysfunction and oxidative stress.

Histopathological and biochemical studies on the effect of curcumin and taurine against bisphenol A toxicity in male rats.

Neurochemical characterization of the enteric neurons within the porcine jejunum in physiological conditions and under the influence of bisphenol A (BPA).

[The role of hypothalamus polycomb gene methylation in bisphenol A exposure during pregnancy and premature puberty in female offspring]. [Chinese]

Developmental Programming: Changes in Mediators of Insulin Sensitivity in Prenatal Bisphenol A-treated Female Sheep.

Nonylphenol can aggravate allergic rhinitis in a murine model by regulating important Th cell subtypes and their associated cytokines.

The effects of bisphenol A, benzyl butyl phthalate, and di(2-ethylhexyl) phthalate on estrogen receptor alpha in estrogen receptor-positive cells under hypoxia. [BPA and phthalates]

Phthalates

Comparing the effects of diethylhexyl phthalate and dibutyl phthalate exposure on hypertension in mice.

Neural mechanisms underlying the deficit of learning and memory by exposure to Di(2-ethylhexyl) phthalate in rats.

Independent and combined effects of diethylhexyl phthalate and polychlorinated biphenyl 153 on sperm quality in the human and dog.

DEHP triggers cerebral mitochondrial dysfunction and oxidative stress in quail (Coturnix japonica) via modulating mitochondrial dynamics and biogenesis and activating Nrf2-mediated defense response.

In vitro and in silico hormonal activity studies of di-(2-ethylhexyl)terephthalate, a di-(2-ethylhexyl)phthalate substitute used in medical devices, and its metabolites.

Persistent Organic Pollutants

Rapid Analysis of Effects of Environmental Toxicants on Tumorigenesis and Inflammation Using a Transgenic Zebrafish Model for Liver Cancer. [BPA, metals, PCBs, TCDD, etc.]

Polychlorinated Biphenyls promote cell survival through pyruvate kinase M2-dependent glycolysis in HeLa cells.

2,3,7,8-Tetrachlorodibenzo-p-dioxin and TGFβ3-Mediated Mouse Embryonic Palatal Mesenchymal Cells.

Perfluoroalkyl Substances

Estrogenic effects of fluorinated diiodine alkanes in MCF-7 cells, H295R cells and zebrafish embryo assays.

Antioxidant defence system is responsible for the toxicological interactions of mixtures: A case study on PFOS and PFOA in Daphnia magna.

Toxicokinetics of perfluorinated alkyl acids influences their toxic potency in the zebrafish embryo ( Danio rerio).

Effect of perfluorooctanesulfonate exposure on steroid hormone levels and steroidogenic enzyme activities in juvenile Silurana tropicalis.

Flame Retardants

Maternal exposure to low dose BDE209 and Pb mixture induced neurobehavioral anomalies in C57BL/6 male offspring. [lead and PBDE]

Transcriptomic analyses of human bronchial epithelial cells BEAS-2B exposed to brominated flame retardant (tetrabromobisphenol A).

Tris (1,3-dichloro-2-propyl) phosphate treatment induces DNA damage, cell cycle arrest and apoptosis in murine RAW264.7 macrophages.

Establishment of a human embryonic stem cell-based liver differentiation model for hepatotoxicity evaluations. [PBDEs]

Pesticides

Effects of single and combined exposure to nano and bulk zinc-oxide and propiconazole on Enchytraeus albidus.

Accumulation and toxicity of thiamethoxam and its metabolite clothianidin to the gonads of Eremias argus.

The protective effects of melatonin on oxidative damage and the immune system of the Chinese mitten crab (Eriocheir sinensis) exposed to deltamethrin.

The lipid metabolism alteration of three spirocyclic tetramic acids on zebrafish (Danio rerio) embryos.

Maternal exposure to imazalil disrupts the endocrine system in F1 generation mice.

Arsenic/Metals

Arsenic exposure intensifies glycogen nephrosis in diabetic rats.

Heavy metal exposure causes changes in the metabolic health-associated gut microbiome and metabolites.

Variation in transcriptional responses to copper exposure across Daphnia pulex lineages.

Sulforaphane potentially attenuates arsenic-induced nephrotoxicity via the PI3K/Akt/Nrf2 pathway in albino Wistar rats.

Prolonged inorganic arsenic exposure via drinking water impairs brown adipose tissue function in mice.

Interactive effects of As, Cd and Zn on their uptake and oxidative stress in As-hyperaccumulator Pteris vittata.

Organotins

Organotin compound DBDCT induces CYP3A suppression through NF-κB-mediated repression of PXR activity.

TCE

Differential toxicity of water versus gavage exposure to trichloroethylene in rats.

Miscellaneous

Maternal Engineered Nanomaterial Inhalation During Gestation Disrupts Vascular Kisspeptin Reactivity.

Biological effects of the benzotriazole ultraviolet stabilizers UV-234 and UV-320 in early-staged zebrafish (Danio rerio).

Toxic effects of chemical warfare agent mixtures on the mussel Mytilus trossulus in the Baltic Sea: A laboratory exposure study.

Deepwater Horizon crude oil exposure alters cholesterol biosynthesis with implications for developmental cardiotoxicity in larval mahi-mahi (Coryphaena hippurus).

Development of interspecies correlation estimation (ICE) models to predict the reproduction toxicity of EDCs to aquatic species.

Wildlife/Environment/Exposure Studies

Phenols

Alkylphenol ethoxylate metabolites in coastal sediments off southwestern Taiwan: Spatiotemporal variations, possible sources, and ecological risk.

Occurrence and level of emerging organic contaminant in fish and mollusk from Klang River estuary, Malaysia and assessment on human health risk. [phenols, pharmaceuticals, pesticides]

Phthalates

DEHP as a chemical indicator for PAEs: An investigation into PAEs in cultivated fields and E-waste dismantling sites.

Phthalates in residential and agricultural soils from an electronic waste-polluted region in South China: distribution, compositional profile and sources.

Distribution of phthalate esters in air, water, sediments, and fish in the Asan Lake of Korea.

Persistent Organic Pollutants

Characterization of Tibetan soil as a source or sink of atmospheric persistent organic pollutants: Seasonal shift and impact of global warming.

Traditional Diet and Environmental Contaminants in Coastal Chukotka I: Study Design and Dietary Patterns.

Traditional Diet and Environmental Contaminants in Coastal Chukotka II: Legacy POPs.

Traditional Diet and Environmental Contaminants in Coastal Chukotka IV: Recommended Intake Criteria.

Snow buntings (Plectrophenax nivealis) as bio-indicators for exposure differences to legacy and emerging persistent organic pollutants from the Arctic terrestrial environment on Svalbard.

High Abundance of Unintentionally Produced Tetrachlorobiphenyls (PCB47/48/75, 51, and 68) in the Atmosphere at a Regional Background Site in East China.

Abundance of diet-derived polychlorinated dibenzo-p-dioxins and polychlorinated dibenzofurans in the bodies and nests of the yellow-legged hornet Vespa velutina nigrithorax and risks to human health in South Korea.

HCH and lindane contaminated sites: European and global need for a permanent solution for a long-time neglected issue.

Trace metals and persistent organic pollutants contamination in batoids (Chondrichthyes: Batoidea): A systematic review.

Characterization of PCDD/Fs and dl-PCBs emission from combustion of PCB-containing oil in a fluidized-bed incinerator.

Contaminant exposure linked to cellular and endocrine biomarkers in southern California bottlenose dolphins.

Perfluoroalkyl Substances

Per- and polyfluorinated compounds in saleswomen’s urine linked to indoor dust in clothing shops.

Organochlorines, perfluoroalkyl substances, mercury, and egg incubation temperature in an Arctic seabird: Insights from data loggers.

Flame Retardants

Seasonal variation and human exposure assessment of legacy and novel brominated flame retardants in PM2.5 in different microenvironments in Beijing, China.

First determination of high levels of organophosphorus flame retardants and plasticizers in dolphins from Southern European waters.

Flame retardant concentrations and profiles in wild birds associated with landfill: A critical review.

Occurrence of halogenated flame retardants in sediments and sea urchins (Paracentrotus lividus) from a North African Mediterranean coastal lagoon (Bizerte, Tunisia).

Species and habitat-dependent accumulation and biomagnification of brominated flame retardants and PBDE metabolites.

Arsenic/Metals

Traditional Diet and Environmental Contaminants in Coastal Chukotka III: Metals.

Accumulation and distribution of arsenic and cadmium in winter wheat (Triticum aestivum L.) at different developmental stages.

The Bioaccumulation and Tissue Distribution of Arsenic Species in Tilapia.

Florida Arsenic Distribution Index: Quantifying the Distribution of Past and Present Arsenic Usage.

Investigation of occupational exposure to lead and its relation with blood lead levels in electrical solderers.

Risks and benefits of consuming edible seaweeds.

Assessment of the human health risks of heavy metals in nine typical areas.

Heavy metals contamination in urban surface soils of Medak province, India, and its risk assessment and spatial distribution.

Field testing of over 30,000 wells for arsenic across 400 villages of the Punjab plains of Pakistan and India: Implications for prioritizing mitigation.

Distribution of potentially harmful elements in soils around a large coal-fired power plant.

Municipal solid wastes as a resource for environmental recovery: Impact of water treatment residuals and compost on the microbial and biochemical features of As and trace metal-polluted soils.

Trace metals in polyethylene debris from the North Atlantic subtropical gyre.

Distribution of the bioavailable and total content of copper and lead, in river sediments of the Jamapa-Atoyac fluvial system, Mexico.

Miscellaneous

Emerging pollutants in the urban water cycle in Latin America: A review of the current literature.

Hormones and Pharmaceuticals in Groundwater Used As a Source of Drinking Water Across the United States.

Toxicological and ecotoxicological evaluation of the water quality in a large and eutrophic freshwater lake of China.

Accumulation of Short-, Medium-, and Long-chain Chlorinated Paraffins in Marine and Terrestrial Animals from Scandinavia.

This list is not meant to be exhaustive, and generally does not include studies on detection, remediation, or treatment of EDCs. Note that journal publication dates may be different than dates added to PubMed. Compiled by Sarah Howard, Diabetes and Environment Program at Commonweal.