A summary of articles on endocrine disrupting chemicals (EDCs) added to PubMed this week.
Contents: Interesting Research of the Week,Regulations/Policy, Reviews, Human Health Studies, Laboratory Studies, and Wildlife/Environment/Exposure Studies.
Interesting Research of the Week
Three second-generation human exposure studies:
Perinatal polychlorinated biphenyls and polychlorinated dibenzofurans exposure are associated with DNA methylation changes lasting to early adulthood: Findings from Yucheng second generation.
Prenatal dioxin exposure and neuropsychological functioning in the Seveso Second Generation Health Study.
In utero dioxin exposure and cardiometabolic risk in the Seveso Second Generation Study.
Regulations/Policy
Building Capacity in Pediatric Environmental Health: A Fifteen-Year Report on the Academic Pediatric Association’s Professional Development Program.
The negative impact of the environment on methylation/epigenetic marking in gametes and embryos: A plea for action to protect the fertility of future generations.
Reviews
A systematic review: Impact of endocrine disrupting chemicals exposure on fecundity as measured by time to pregnancy.
“Bisphenol a: an emerging threat to male fertility”.
Chemical activation of estrogen and aryl hydrocarbon receptor signalling pathways and their interaction in toxicology and metabolism.
Review of emerging concepts in nanotoxicology: opportunities and challenges for safer nanomaterial design.
Water and soil pollution as determinant of water and food quality/contamination and its impact on female fertility.
Fish Consumption During Pregnancy.
Ameliorative and protective effects of ginger and its main constituents against natural, chemical and radiation-induced toxicities: A comprehensive review.
Persistent Organic Pollutants
Perfluorohexanoic acid toxicity, part I: Development of a chronic human health toxicity value for use in risk assessment.
Metals
Systematic review of arsenic in fresh seafood from the Mediterranean Sea and European Atlantic coasts: A health risk assessment.
Human Health Studies
BPA/Phenols/Phthalates
Serum levels of phthalates and bisphenol-A in patients with primary ovarian insufficiency.
Bisphenol A levels are inversely associated with serum vitamin D-binding protein and sex hormone-binding globulin levels in women with polycystic ovary syndrome: a pilot study.
Urinary metabolites of dibutyl phthalate and benzophenone-3 are potential chemical risk factors of chronic kidney function markers among healthy women.
Persistent Organic Pollutants
Persistent organic pollutants and gestational diabetes: A multi-center prospective cohort study of healthy US women. [PCBs, PBDEs, PFASs, OCPs]
Long-term airborne dioxin exposure and breast cancer risk in a case-control study nested within the French E3N prospective cohort.
Perfluoroalkyl Substances
Isomers of perfluoroalkyl substances and overweight status among Chinese by sex status: Isomers of C8 Health Project in China.
PFOS, PFOA, estrogen homeostasis, and birth size in Chinese infants.
Associations between repeated measure of plasma perfluoroalkyl substances and cardiometabolic risk factors.
Prenatal perfluorooctanoic acid exposure and glutathione s-transferase T1/M1 genotypes and their association with atopic dermatitis at 2 years of age.
Association of Perfluoroalkyl and Polyfluoroalkyl Substances With Adiposity. [from Aug. but just added to PubMed]
Autism spectrum disorders, endocrine disrupting compounds, and heavy metals in amniotic fluid: a case-control study. [PFASs and metals]
Pesticides
High Pesticide Exposure Events and Olfactory Impairment among U.S. Farmers.
Arsenic/Metals
Placental metal concentrations and birth outcomes: The Environment and Childhood (INMA) project.
Pre- and postnatal environmental boron exposure and infant growth: Results from a mother-child cohort in northern Argentina.
Plasma selenium influences arsenic methylation capacity and developmental delays in preschool children in Taiwan.
Auditory brainstem response analysis for long-term central auditory function sequelae in patients with chronic arsenic intoxication: A cross-sectional study.
Laboratory Studies
BPA/Phenols
Chemical Contaminants from Plastics in the Animal Environment. [“housing mice in damaged polysulfone cages resulted in harmful effects due to exposure to BPS… BPS can cross-contaminate new or undamaged cages in facilities that process damaged caging materials… Only the replacement of all cages and water bottles in the facility corrected the problem.”]
Neurotoxicity of nonylphenol exposure on Caenorhabditis elegans induced by reactive oxidative species and disturbance synthesis of serotonin.
Toxic effects of bisphenol A on goldfish gonad development and the possible pathway of BPA disturbance in female and male fish reproduction.
Comparison of thyroid hormone disruption potentials by bisphenols A, S, F, and Z in embryo-larval zebrafish.
Adverse effects of bisphenol A on Sertoli cell blood-testis barrier in rare minnow Gobiocypris rarus.
Bisphenol S (BPS) triggers the migration of human non-small cell lung cancer cells via upregulation of TGF-β.
Activation of Sirtuin 3 and Maintenance of Mitochondrial Integrity by N-Acetylcysteine Protects Against Bisphenol A-Induced Kidney and Liver Toxicity in Rats.
Is bisphenol S a safer alternative to bisphenol A in terms of potential fetal exposure ? Placental transfer across the perfused human placenta.
Bisphenol S increases EZRIN expression and the detrimental effects induced by dehydroepiandrosterone in rat endometrium.
Vitis vinifera (grape) seed extract and resveratrol alleviate bisphenol-A-induced metabolic syndrome: Biochemical and molecular evidences.
A Conflicted Tale of Two Novel AR Antagonists In vitro and In vivo: Pyrifluquinazon versus Bisphenol C.
Long-term bisphenol S exposure induces fat accumulation in liver of adult male zebrafish (Danio rerio) and slows yolk lipid consumption in F1 offspring.
Phthalates
Developmental Exposure to Di-(2-ethylhexyl) Phthalate Induces Cerebellar Granule Cell Apoptosis via the PI3K/AKT Signaling Pathway.
Sub-Chronic Exposure to Di(2-ethylhexyl) Phthalate and Diisononyl Phthalate During Adulthood Has Immediate and Long-Term Reproductive Consequences in Female Mice.
Redox Regulation of Hormone Sensitive Lipase: Potential Role in the Mechanism of MEHP-Induced Stimulation of Basal Steroid Synthesis in MA-10 Leydig Cells.
Transgenerational impact of DEHP on body weight of Drosophila.
Effect of the TYK-2/STAT-3 pathway on lipid accumulation induced by mono-2-ethylhexyl phthalate.
In utero exposure to di(2-ethylhexyl)phthalate suppresses blood glucose and leptin levels in the offspring of wild-type mice.
Effects of combined exposure of adult male mice to di-(2-ethylexyl)phthalate and nonylphenol on behavioral and neuroendocrine responses.
Di (2-ethylhexyl) phthalate induces cardiac disorders in BALB/c mice.
Parabens/Triclosan/Antimicrobials
Developmental toxicity of triclocarban in zebrafish (Danio rerio) embryos.
Persistent Organic Pollutants
The role of prostaglandin E2 receptor EP1 in 2,3,7,8-tetrachlorodibenzo-p-dioxin-induced neonatal hydronephrosis in mice.
Perfluoroalkyl Substances
Toxicokinetics and toxic effects of a Chinese PFOS alternative F-53B in adult zebrafish.
In Vitro and In Silico Evaluations of Binding Affinities of Perfluoroalkyl Substances to Baikal Seal and Human Peroxisome Proliferator-Activated Receptor α.
Protonation state effects of estrogen receptor α on the recognition mechanisms by perfluorooctanoic acid and perfluorooctane sulfonate: A computational study.
Dose effects of ammonium perfluorooctanoate on lipoprotein metabolism in APOE*3-Leiden.CETP mice.
Flame Retardants
Are cell phones an indicator of personal exposure to organophosphate flame retardants and plasticizers?
Pesticides
Direct and indirect parental exposure to endocrine disruptors and elevated temperature influences gene expression across generations in a euryhaline model fish. [bifenthrin and ethinylestradiol]
Sub-toxic exposure to lindane activates redox sensitive kinases and impairs insulin signaling in muscle cell culture: The possible mechanism of lindane-induced insulin resistance.
The azole fungicide tebuconazole affects human CYP1A1 and CYP1A2 expression by an aryl hydrocarbon receptor-dependent pathway.
Arsenic/Metals
Memory effect of arsenic-induced cellular response and its influences on toxicity of titanium dioxide nanoparticle.
The toxicity of exogenous arsenic to soil-dwelling springtail Folsomia candida in relation to soil properties and aging time.
Metal carcinogen exposure induces cancer stem cell-like property through epigenetic reprograming: A novel mechanism of metal carcinogenesis.
Inorganic arsenic induces pyroptosis and pancreatic β cells dysfunction through stimulating the IRE1α/TNF-α pathway and protective effect of taurine.
Aluminum disrupts the prenatal development of the male and female gerbil prostate (Meriones unguiculatus).
Pharmaceuticals
Mating under the influence: male Siamese fighting fish prefer EE2-exposed females.
Acute and Chronic Toxicity of Carbamazepine on the Release of Chitobiase, Molting, and Reproduction in Daphnia similis.
Transcriptomic analysis of short-term 17α-ethynylestradiol exposure in two Californian sentinel fish species sardine (Sardinops sagax) and mackerel (Scomber japonicus).
The endocrine disruptor, 17α-ethinyl estradiol, alters male mate choice in a freshwater fish.
Mixtures
Investigation of the Synergistic Toxicity of Binary Mixtures of Pesticides and Pharmaceuticals on Aliivibrio fischeri in Major River Basins in South Korea.
Long-term exposure to chemicals in sewage sludge fertilizer alters liver lipid content in females and cancer marker expression in males.
Miscellaneous
Characterization of the modes of action and dose-response relationship for thiocyanate on the thyroid hormone levels in rats using a computational approach.
The retinoic acid receptor (RAR) in molluscs: Function, evolution and endocrine disruption insights.
Chemometric modeling of aquatic toxicity of contaminants of emerging concern (CECs) in Dugesia japonica and its interspecies correlation with daphnia and fish: QSTR and QSTTR approaches.
Gas chromatographic-mass spectrometric analysis of sunscreens and their effects on mice liver and kidney enzyme function.
Size-dependent effects of polystyrene microplastics on cytotoxicity and efflux pump inhibition in human Caco-2 cells.
Exposure to Titanium Dioxide Nanoparticles During Pregnancy Changed Maternal Gut Microbiota and Increased Blood Glucose of Rat.
Wildlife/Environment/Exposure Studies
BPA/Phenols
BPA, BADGE and analogues: A new multi-analyte LC-ESI-MS/MS method for their determination and their in vitro (anti)estrogenic and (anti)androgenic properties.
Consequences of a contaminant mixture of bisphenol A (BPA) and di-(2-ethylhexyl) phthalate (DEHP), two plastic-derived chemicals, on the diversity of coastal phytoplankton.
Phthalates
Human exposure to phthalate esters associated with e-waste dismantling: Exposure levels, sources, and risk assessment.
Exposure and ecological risk of phthalate esters in the Taihu Lake basin, China.
Steady-State Human Pharmacokinetics of Monobutyl Phthalate Predicted by Physiologically Based Pharmacokinetic Modeling Using Single-Dose Data from Humanized-Liver Mice Orally Administered with Dibutyl Phthalate.
Using solitary ascidians to assess microplastic and phthalate plasticizers pollution among marine biota: A case study of the Eastern Mediterranean and Red Sea.
Sanitary pads and diapers contain higher phthalate contents than those in common commercial plastic products.
Persistent Organic Pollutants
Characterization, source identification and risk associated with polyaromatic and chlorinated organic contaminants (PAHs, PCBs, PCBzs and OCPs) in the surface sediments of Hooghly estuary, India.
An evaluation of the levels of organochlorine compounds (OCPs and PCBs) in cultured freshwater and wild sea fish eggs as an exposure biomarker for environmental contamination.
Biological toxicity estimates show involvement of a wider range of toxic compounds in sediments from Durban, South Africa than indicated from instrumental analyses.
Bioavailability and distribution of PAHs and PCBs in the sediment pore water of the German Bight and Wadden Sea.
Threats of indicator polychlorinated biphenyls (PCBs) in six molluscs from market to food safety: A case study in Haikou City, China.
Perfluoroalkyl Substances
The occurrence of perfluoroalkyl acids in an important feed material (fishmeal) and its potential risk through the farm-to-fork pathway to humans.
Perfluoroalkyl substances in the riverine and coastal water of the Beibu Gulf, South China: Spatiotemporal distribution and source identification.
Perfluorinated alkyl substances in snow as an atmospheric tracer for tracking the interactions between westerly winds and the Indian Monsoon over western China.
Flame Retardants
In situ Microbial Degradation of PBDEs in Sediments from an e-Waste Site as Revealed by Positive Matrix Factorization and Compound-Specific Stable Carbon Isotope Analysis.
Trace metals in e-waste lead to serious health risk through consumption of rice growing near an abandoned e-waste recycling site: Comparisons with PBDEs and AHFRs.
Levels, distributions, and ecological risk assessments of polybrominated diphenyl ethers and alternative flame retardants in river sediments from Vaal River, South Africa.
Measurement of legacy and emerging flame retardants in indoor dust from a rural village (Kopawa) in Nepal: Implication for source apportionment and health risk assessment.
Arsenic/Metals
The reduction of toxic metals of various rice types by different preparation and cooking processes – Human health risk assessment in Tehran households, Iran.
Cadmium and arsenic accumulation during the rice growth period under in situ remediation.
Affordable and efficient adsorbent for arsenic removal from rural water supply systems in Newfoundland.
The microbiomic and environmental analysis of sediments in the Indo-Pacific humpback dolphin (Sousa chinensis) habitat in the Northern Beibu Gulf, China.
Occurrence, distribution and ecological risk of trace metals and organic pollutants in surface sediments from a Southeastern European river (Someşu Mic River, Romania).
Trace elements bioaccumulation in Porcellionides pruinosus (Brandt, 1833) and related biomarkers of exposure.
Spatial distribution and vertical profile of heavy metals in marine sediments around Iran’s special economic energy zone; Arsenic as an enriched contaminant.
Occurrence, toxicity, and speciation analysis of arsenic in edible mushrooms.
Organotins
Distribution of butyltins at dredged material dumping sites around the coast of China and the potential ecological risk.
Spatiotemporal distribution of organotin compounds in the coastal water of the Bahía Blanca estuary (Argentina).
Miscellaneous
Distribution, Toxic Potential, and Influence of Land Use on Conventional and Emerging Contaminants in Urban Stormwater Pond Sediments.
Modeling the toxicity of dissolved crude oil exposures to characterize the sensitivity of cod (Gadus morhua) larvae and role of individual and unresolved hydrocarbons.
Monitoring of prenatal exposure to organic and inorganic contaminants using meconium from an Eastern Canada cohort. [metals, parabens, pharmaceuticals, etc.]
This list is not meant to be exhaustive, and generally does not include studies on detection, remediation, or treatment of EDCs. Note that journal publication dates may be different than dates added to PubMed. Compiled by Sarah Howard, Diabetes and Environment Program at Commonweal
